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AcelRx commences third ARX-01 Phase 3 study in post-operative pain

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of acute and breakthrough pain, today announced dosing of the first patient in the third of three planned Phase 3 studies for ARX-01, the Sufentanil NanoTab PCA System, its novel sublingual patient-controlled analgesia (PCA) system.

24 Aug 2012

FDA approves Watson’s ANDA for lidocaine topical patch 5%

Watson Pharmaceuticals, Inc. today announced that its subsidiary, Watson Laboratories, Inc., has received final approval from the United States Food and Drug Administration (FDA) on its Abbreviated New Drug Application (ANDA) for lidocaine topical patch 5%, the generic equivalent to Endo's Lidoderm.

24 Aug 2012

Roundup: Ore. lawmakers examine 'disclosure' as way to limit malpractice claims; $2.8M in fraudulent public assistance given in Mass.; Md. exchange announcement Thursday

Lawmakers are expected to take up tort reform when the Oregon Legislature convenes next February. To get those discussions moving, a Patient Safety and Defensive Medicine Workgroup is developing draft legislation that includes issues such as confidentiality, mediation, dispute resolution, litigation, discovery and patient safety. Disclosure -- informing patients when a serious medical event has occurred in a hospital setting -- is also on the table.

24 Aug 2012

UK carotid endarterectomy results revealed

Round 4 of the UK Carotid Endarterectomy Audit, organized by the Royal College of Physicians, has revealed that the average delay from stroke or transient ischemic attack symptom onset to surgery is shortening.

23 Aug 2012

Concern over ameba-infested tap water deaths

People with sinusitis who regularly treat their condition using nasal irrigation should be aware of a potential contamination risk associated with using inadequately filtered tap water, say US researchers.

23 Aug 2012

Inappropriate prescriptions for the elderly prevalent in primary care

One in five prescriptions in primary care for the elderly is inappropriate, say the authors of a systematic review.

23 Aug 2012

Hand-held CO2 monitors could improve school air quality

A new hand-held sensor may be the answer to improving air quality in schools, say researchers.

23 Aug 2012

Adult surgery rescues overcorrected club foot deformity

Study findings support the use of supramalleolar osteotomy for patients with hindfoot valgus or subtalar joint deformity following an overcorrected clubfoot.

23 Aug 2012

Novel questionnaire reliably assesses antiepileptic adverse effects in children

The adverse effects of antiepileptic drugs can be reliably measured in children from across the epilepsy spectrum in clinical and research settings with the novel Pediatric Epilepsy Side Effects Questionnaire, say US scientists.

23 Aug 2012

Poor affect recognition may not predict psychosis in high-risk patients

Decreased affect recognition is associated with psychosis vulnerability, but it is not a marker of conversion to psychosis in high-risk individuals, researchers report.

23 Aug 2012

Annual follow up after ESD for early gastric cancer recommended

Almost all recurrent lesions in gastric epithelial cancer could be cured by endoscopic submucosal resection with annual follow-up exams, say the authors of a Japanese study.

23 Aug 2012

Schizophrenia patients benefit from text message reminders

A text message-based service may help improve medication adherence in patients with schizophrenia, researchers report.

23 Aug 2012

Nicotine dependence risk increased in bipolar disorder

Adults with mood and anxiety disorders are significantly more likely to be smokers than the general population, a US study of data from the National Epidemiologic Survey of Alcohol and Related Conditions shows.

23 Aug 2012

Salivary IL-6 could predict recurrence after surgery in mouth cancer patients

Salivary levels of the proinflammatory cytokine interleukin-6 could be a useful predictor for locoregional recurrence in oral squamous cell carcinoma patients who are treated surgically, report researchers.

23 Aug 2012

Nonoperative management of inflamed gallbladder may be best for elderly

Medical rather than surgical management of acute cholecystitis – or inflamed gallbladder – may be the most appropriate option for elderly patients who may be unsuitable for surgery, report researchers.

23 Aug 2012

Fizzy tablet is best method to receive fentanyl for cancer pain

Results of a mixed treatment comparison show that fentanyl in the form of an effervescent buccal tablet can better relieve the intensity of breakthrough cancer pain in the first 60 minutes after dosing compared with other fentanyl formulations.

23 Aug 2012

New UCLA study pinpoints unique human patterns of gene activity in the brain

Human and chimp brains look anatomically similar because both evolved from the same ancestor millions of years ago. But where does the chimp brain end and the human brain begin? A new UCLA study pinpoints uniquely human patterns of gene activity in the brain that could shed light on how we evolved differently than our closest relative.

23 Aug 2012

Researcher describes structure and function of tuberculosis efflux pump regulator

Edward Yu took note of the facts - nearly 2 million deaths each year, 9 million infected each year, developments of multidrug-resistant, extensively drug-resistant and now totally drug-resistant strains - and decided to shift his research focus to tuberculosis.

23 Aug 2012

Microtubule stiffening worsens skeletal muscle degeneration in Duchenne muscular dystrophy

University of Maryland (UM) researchers and collaborators report in the journal Science Signaling that skeletal muscle degeneration in Duchenne muscular dystrophy (DMD) is worsened by stiffening of the microtubule cytoskeleton that provides structure inside muscle cells.

23 Aug 2012

Food insecure HIV-infected poor people more likely to visit ERs

UCSF researchers found that poor HIV-infected individuals living in San Francisco are significantly more likely to visit emergency rooms and to have hospital stays if they lack access to food of sufficient quality and quantity for a healthy life.

23 Aug 2012