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Four caged xanthones can inhibit growth of CCA cell lines: Research article

Cholangiocarcinoma is a malignant tumor, characterized by a poor prognosis and unresponsive to conventional chemotherapeutic agents. Therefore, searching for novel and effective therapeutic agents for CCA is necessary. In previous studies, several caged xanthones from G. hanburyi have been reported to be potent antiproliferatives as well as having anticancer and anti-tumor activities and they induce apoptosis in various cancer cell lines.

13 May 2010

Study compares outcome of popular esophageal stents in patients with dysphagia

Less than 50% of patients with esophageal carcinoma are suitable for surgery at the time of diagnosis. Most of these patients present with locally advanced or metastatic disease and/or significant comorbidities. In such circumstances, the only therapeutic option is palliative care to treat dysphagia and prevent respiratory complications secondary to aspiration. Self-expanding metal stents have been proven effective for palliation of dysphagia in patients with esophageal carcinoma, tracheo-esophageal fistulas or anastomotic leaks.

13 May 2010

Individual's lifestyle choices can affect cholesterol, triglycerides levels: Mayo Clinic Health Letter

Diet and lifestyle choices aren't only evident on the bathroom scale. The effect of these choices is also reflected with relative accuracy in cholesterol numbers.

13 May 2010

Additional benefits of LAIAs over long-acting human insulin not been proven

It has so far not been proven that the long-acting insulin analogues (LAIAs) insulin detemir (trade name: Levemir) and insulin glargine (trade name: Lantus), which are approved for the treatment of type 1 diabetes, offer patients an additional benefit versus long-acting human insulin. This applies to adults as well as to children and adolescents. This is the result of the final report published by the Institute for Quality and Efficiency in Health Care (IQWiG) on 19 April 2010.

13 May 2010

Study: Treating serious gum disease in diabetics can help lower blood sugar levels

Researchers have found that reducing inflammation of the gums in people with diabetes can help lower the risk of serious complications associated with the condition, such as eye problems and heart disease.

13 May 2010

Florida weighs next steps for small business insurance exchange; N.J. considers COBRA eligibility expansion; Other highlights

When Republican lawmakers created the Florida Health Choices program in 2008, they billed it as a way to deregulate the health-care market for small businesses. Two years later, Florida Health Choices has still not started offering coverage, and its leaders and lawmakers face a philosophical choice that could determine whether the program survives.

13 May 2010

AlphaRx continues to develop Indaflex for the Chinese market

AlphaRx, Inc., has been advised by Cypress Biosciences, its development partner for Indaflex, that Cypress is not funding development of Indaflex. Notwithstanding to the termination of all Indaflex activity in the U.S.A., AlphaRx continues to develop Indaflex for the Chinese market.

13 May 2010

New Melody Transcatheter Pulmonary valve helps congenital heart defect patients avoid multiple surgeries

Congenital heart defects are the most common type of major birth defect in the U.S., affecting about 25,000 babies each year. Now, a new valve being used at the University of Michigan's C.S. Mott Children's Hospital Congenital Heart Center can help patients delay or avoid multiple surgeries.

13 May 2010

Prescription costs more likely to keep Hispanics away from pharmacy counter: Study

Drug costs could prevent some people from filling their prescriptions, which can interfere with optimal health care. A new study of Medicare beneficiaries finds that cost concerns are more likely keep Hispanics away from the pharmacy counter than non-Hispanics.

13 May 2010

Tobacco-free cigarettes may be more carcinogenic than tobacco products: Study

Using the same technique they developed to document the harmful effects of tobacco products, a team of researchers found that cigarettes made without tobacco or nicotine may be more carcinogenic because they actually induce more extensive DNA damage than tobacco products.

13 May 2010

Seriously mentally ill are three times more likely to be imprisoned than hospitalized, report finds

USA Today: "On average, a seriously mentally ill person in the USA is three times more likely to be incarcerated than hospitalized, a report concludes today. In no state was a seriously mentally ill person — someone with schizophrenia or bipolar disorder, for example — less likely to be incarcerated than hospitalized, the report by the National Sheriffs' Association and the Treatment Advocacy Center found.

13 May 2010

NARSAD honours UNC's Patrick Sullivan with 2010 Distinguished Investigator Award

Patrick Sullivan, MD has received a 2010 Distinguished Investigator Award from NARSAD for a comparison of genetics in schizophrenia and bipolar disorder.

13 May 2010

Research sheds light on prenatal heart formation, chromosome 22q.11 deletion syndrome

Researchers studying the common genetic disorder chromosome 22q.11 deletion syndrome have identified key proteins that act together to regulate early embryonic development. One protein is essential to life; in animal studies, embryos without the protein do not survive past the first few days of gestation.

13 May 2010

Advances in vaccine delivery and efficacy discussed at National Immunization Conference

Advances in vaccine delivery and efficacy were discussed at the 44th National Immunization Conference sponsored by the Centers for Disease Control and Prevention. A research study by each of the four directors from the Center for Vaccine Awareness and Research at Texas Children's Hospital was presented.

13 May 2010

Amarin reports cash balance of $44 million for first-quarter 2010

Amarin Corporation plc, a clinical-stage biopharmaceutical company with a focus on cardiovascular disease, today reported selected financial results for the fiscal quarter ended March 31, 2010 and provided a progress update of the Company's ANCHOR and MARINE trials, the two pivotal Phase 3 clinical trials of its lead product candidate AMR101 for treating elevated triglyceride levels.

13 May 2010

World Bank announces five-year plan to reduce maternal deaths, fertility rates in 58 low-income countries

During the release of its five-year plan to help drive down high maternal death and fertility rates in low-income countries, the World Bank on Tuesday said "that family planning and other reproductive health services have fallen off the radar of many governments, donors and aid agencies," Reuters reports.

13 May 2010

St. Jude Medical to display new products, clinical solutions at Heart Rhythm 2010

St. Jude Medical, Inc., a global medical device company, today announced it will display a number of new products and clinical solutions from the company's Cardiac Rhythm Management and Atrial Fibrillation Divisions at Heart Rhythm 2010, the Heart Rhythm Society's 31st Annual Scientific Sessions.

13 May 2010

Tripos releases SYBYL-X 1.1 molecular modeling suite

Tripos®, a leading provider of drug discovery informatics products and services, today announced the release and general availability of SYBYL-X Version 1.1. This new release focuses on enhancing research productivity for scientists in the pharmaceutical, agrochemical, flavors and fragrances, and related industries, featuring faster navigation, new menus and toolbars, and new ways to approach life science molecular discovery projects. Previous SYBYL versions have been the benchmark for the industry in molecular modeling, and customers using this new, next generation version have given it high marks.

13 May 2010

Sex can affect frequency and severity of adverse effects of vaccination

Biological differences between the sexes could be a significant predictor of responses to vaccines, according to researchers at the Johns Hopkins Bloomberg School of Public Health. They examined published data from numerous adult and child vaccine trials and found that sex is a fundamental, but often overlooked predictor of vaccine response that could help predict the efficacy of combating infectious disease.

13 May 2010

Two-thirds of child deaths in 2008 due to infectious diseases, report finds

Pneumonia, diarrhea, malaria and other infectious diseases accounted for two-thirds of the 8.8 million deaths in 2008 among children under age 5 around the world, according to a Lancet study published on Wednesday, HealthDay News/Bloomberg BusinessWeek reports. The highest numbers of childhood deaths were in Africa (4.2 million) and Southeast Asia (2.39 million), according to the news service (5/11).

13 May 2010

Medical News

Four caged xanthones can inhibit growth of CCA cell lines: Research article

Study compares outcome of popular esophageal stents in patients with dysphagia

Individual's lifestyle choices can affect cholesterol, triglycerides levels: Mayo Clinic Health Letter

Additional benefits of LAIAs over long-acting human insulin not been proven

Study: Treating serious gum disease in diabetics can help lower blood sugar levels

Florida weighs next steps for small business insurance exchange; N.J. considers COBRA eligibility expansion; Other highlights

AlphaRx continues to develop Indaflex for the Chinese market

New Melody Transcatheter Pulmonary valve helps congenital heart defect patients avoid multiple surgeries

Prescription costs more likely to keep Hispanics away from pharmacy counter: Study

Tobacco-free cigarettes may be more carcinogenic than tobacco products: Study

Seriously mentally ill are three times more likely to be imprisoned than hospitalized, report finds

NARSAD honours UNC's Patrick Sullivan with 2010 Distinguished Investigator Award

Research sheds light on prenatal heart formation, chromosome 22q.11 deletion syndrome

Advances in vaccine delivery and efficacy discussed at National Immunization Conference

Amarin reports cash balance of $44 million for first-quarter 2010

World Bank announces five-year plan to reduce maternal deaths, fertility rates in 58 low-income countries

St. Jude Medical to display new products, clinical solutions at Heart Rhythm 2010

Tripos releases SYBYL-X 1.1 molecular modeling suite

Sex can affect frequency and severity of adverse effects of vaccination

Two-thirds of child deaths in 2008 due to infectious diseases, report finds

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