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Pneumococcal polysaccharide vaccines do not appear to protect against pneumonia

Commonly used pneumococcal polysaccharide vaccines do not appear to be effective for preventing pneumonia, found a study by a team of researchers from Switzerland and the United Kingdom.

5 Jan 2009

Phase 3 trial begins for Gammagard liquid plus rHuPH20 in primary immunodeficiency patients

Baxter International Inc. and Halozyme Therapeutics, Inc. gas announced the start of a Phase 3 clinical trial of Baxter's Gammagard Liquid [Immune Globulin Intravenous] 10% (IGIV), marketed as KIOVIG in the European Union, with Halozyme's recombinant human hyaluronidase enzyme (rHuPH20, Enhanze Technology) for the treatment of primary immunodeficiency (PID).

From Baxter International Inc. 5 Jan 2009

New insight into critical molecular mechanisms involved in aggressive childhood cancer

A new study reveals critical molecular mechanisms associated with the development and progression of human neuroblastoma, the most common cancer in young children.

5 Jan 2009

Old Digitalis-based drugs show promise as a treatment for cancer

Digitalis-based drugs like digoxin have been used for centuries to treat patients with irregular heart rhythms and heart failure and are still in use today.

5 Jan 2009

Why stopping smoking is hard

Just seeing someone smoke can trigger smokers to abandon their nascent efforts to kick the habit, according to new research conducted at Duke University Medical Center.

5 Jan 2009

Appropriate use criteria for coronary revascularization

If you're committed to fitness, the decision to climb a couple of flights of stairs rather than take the elevator is clear. But if you develop chest pain on the way up, deciding how to treat the symptoms of clogged arteries in your heart is much more complicated.

5 Jan 2009

Molecular insight into how a heart failure drug in clinical trials works

Individuals who have persistent high blood pressure are at increased risks of a number of serious medical conditions, including heart failure.

5 Jan 2009

Mothers pass on disease clues, prime offspring for the environment they will live in

When there is a threat of disease during pregnancy, mothers produce less aggressive sons with more efficient immune systems, researchers at The University of Nottingham have discovered.

5 Jan 2009

New methods for studying DNA repair and protein modification

This month's issue of Cold Spring Harbor Protocols features two articles detailing experimental methods for the analysis of molecular processes involved in DNA repair and post-translational modification of proteins.

5 Jan 2009

Researchers look at global endometrial ablation procedure for heavy menstrual bleeding

Experts estimate that 20 percent of women experience excessive or prolonged menstrual bleeding at some time during their lives, particularly as they approach menopause.

5 Jan 2009

Many teens discuss health risk behaviors on social networking websites

In a pair of related studies released by Seattle Children's Research Institute and published in the January 2009 issue of Archives of Pediatric & Adolescent Medicine , researchers found that 54 percent of adolescents frequently discuss high-risk activities including sexual behavior, substance abuse or violence using MySpace, the popular social networking Web site (SNS).

5 Jan 2009

'Low-carb' best diets for type 2 diabetes

In a six-month comparison of low-carb diets, one that encourages eating carbohydrates with the lowest-possible rating on the glycemic index leads to greater improvement in blood sugar control, according to Duke University Medical Center researchers.

5 Jan 2009

How loss or mutation of LMNA gene causes Emery-Dreifuss muscular dystrophy

Mutations in the nuclear intermediate filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms.

5 Jan 2009

Simple test kit helps prevent lung cancer caused by radon

Using a simple, inexpensive test to detect radon gas seeping into homes could help prevent lung cancer and save thousands of lives, Acting Department of Environmental Protection Secretary John Hanger said today.

5 Jan 2009

Indevus Pharmaceuticals enters merger agreement with Endo Pharmaceuticals

Indevus Pharmaceuticals, Inc. has announced that it has entered into a definitive merger agreement under which Endo Pharmaceuticals Holdings, Inc.

5 Jan 2009

Debate on treating fevers in African children

A new debate in the open access journal PLoS Medicine questions whether all African children with fever should be treated presumptively with antimalarial drugs, or if treatment should wait until laboratory tests confirm malarial infection.

5 Jan 2009

Metadherin gene plays dual role in breast cancers with poor prognosis

A new study reveals that the metadherin gene (MTDH) plays a role in both cancer metastasis and resistance to chemotherapy.

5 Jan 2009

Antibodies take 'evolutionary leaps' to fight microbes

With cold and flu season in full swing, the fact that viruses and bacteria rapidly evolve is apparent with every sneeze, sniffle, and cough.

5 Jan 2009

Endo Pharmaceuticals to acquire Indevus Pharmaceuticals

Endo Pharmaceuticals (NASDAQ:ENDP) and Indevus Pharmaceuticals, Inc. (NASDAQ: IDEV) announced today that they have entered into a merger agreement under which Endo will commence a tender offer to acquire 100 percent of the outstanding shares of Indevus for approximately $370 million, or $4.50 per Indevus share, in cash, and up to an additional approximately $267 million, or $3.00 per Indevus share, in cash payable in the future upon achievement of certain regulatory and sales milestones.

5 Jan 2009

Cylene Pharmaceuticals starts CX-4945 trial - first-in class inhibitor of CK2

Cylene Pharmaceuticals announced today that it has initiated a Phase I clinical trial of its oral CK2 protein kinase inhibitor, CX-4945, in patients with advanced solid tumors, Castleman's disease, or multiple myeloma.

5 Jan 2009