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Protein structures reveal "big bang" of innovation in evolution

A new study of proteins, the molecular machines that drive all life, also sheds light on the history of living organisms.

11 Mar 2009

Study methods influence estimates of lead time and overdiagnosis in prostate cancer

In prostate cancer, estimates of lead time (how long screening advances diagnosis of cancer) and overdiagnosis (the fraction of cancers detected by screening that would not have been diagnosed during the patient's lifetime without screening) vary widely, depending on the definition of lead time used, the population, and the estimation methodology, according to a report in the March 10 online issue of the Journal of the National Cancer Institute.

11 Mar 2009

Financial incentives stimulate changes in medical practice

A large group of California physicians given financial incentives to improve the quality of medical care have begun to embrace an array of changes important to advancing quality, according to a RAND Corporation study issued today.

11 Mar 2009

Small molecules block cancer gene

Finding molecules that block the activity of the oncogene Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, said a Baylor College of Medicine researcher in a report that appears in the current online issue of the journal PLoS One (Public Library of Science ONE).

11 Mar 2009

Simple test helps predict heart attack risk

The use of common and readily available screening tests - like the ankle brachial index (ABI) - along with traditional risk scoring systems - such as the Framingham Risk Score - has the potential to prevent devastating heart attacks in thousands of individuals who are not originally thought to be at high risk (according to Framingham alone), say researchers at the Society of Interventional Radiology's 34th Annual Scientific Meeting.

11 Mar 2009

Should breast tissue be screened for cancer after mammoplasty?

Young women undergoing cosmetic breast reduction surgery are being screened for cancer without their informed consent, according to a paper published on bmj.com.

11 Mar 2009

'Seeing' stem cells helps in fight against peripheral arterial disease

Interventional radiologists are fitting together the puzzle pieces of how to use stem cells to create new or more blood vessels to treat peripheral arterial disease (PAD) in those individuals with extensively narrowed or clogged arteries.

11 Mar 2009

Scientists discover key molecules that inhibit viral production

The research, led by Professor Donny Strosberg of Scripps Florida, was published on March 4, 2009, in the Journal of General Virology's advance, online edition, Papers in Press.

11 Mar 2009

SOX9 protein may be a potential target for melanoma treatment

In a new study released today, researchers have shown that a specific protein plays an important role in inhibiting the development and spread of melanoma tumors in mouse and in human skin models.

11 Mar 2009

Discovery of new mechanism the malaria parasite uses to enter human red blood cells

Virginia Commonwealth University Life Sciences researchers have discovered a new mechanism the malaria parasite uses to enter human red blood cells, which could lead to the development of a vaccine cocktail to fight the mosquito-borne disease.

11 Mar 2009

Saving limbs with drug-eluting stents

Attempts to treat critical limb ischemia in peripheral arterial disease (PAD) patients with below-the-knee angioplasty are still thwarted by restenosis (the re-narrowing of the artery at the site of angioplasty or stenting), the need for repeat treatments and the continued progression of atherosclerotic disease, leading to tissue death (gangrene) and amputation.

11 Mar 2009

Perinatal environment influences aggression in children

It's a well-documented fact that children from zero to two can be spontaneously aggressive and that boys can be among the worse culprits.

11 Mar 2009

Interventional radiology makes complicated C-sections safer

Innovative, interventional radiology treatments are making childbirth safer for women who have C-sections that are complicated by massive bleeding and for those who suffer from the pregnancy condition of "invasive" placenta.

11 Mar 2009

Extra workplace decibels increase risks of work-related accidents and road collisions

The majority of the 650,000 employees from Quebec's manufacturing sector - specifically those working in metallurgy and sawmilling - are exposed to noise levels that exceed governmental norms.

11 Mar 2009

Risk factors for flat head syndrome

A new study by physician researchers from Hasbro Children's Hospital and Children's Hospital Boston identifies risk factors for the severity of asymmetrical head shapes, known as deformational plagiocephaly (DP), or more commonly as flat head syndrome.

11 Mar 2009

A nanotech coating for brain implants

Biomedical and materials engineers at the University of Michigan have developed a nanotech coating for brain implants that helps the devices operate longer and could improve treatment for deafness, paralysis, blindness, epilepsy and Parkinson's disease.

11 Mar 2009

Childhood diarrhoea needs greater research focus

The list of priority research questions focus on how to make the best use of interventions that are available today, in order to make the most difference, and ultimately save as many children's lives as possible.

11 Mar 2009

Migraines increase stroke risk during pregnancy

Women who suffer migraines are at an increased risk of stroke during pregnancy as well as other vascular conditions such as heart disease, high blood pressure and blood clots, concludes a study published on bmj.com.

11 Mar 2009

Eli Lilly granted temporary restraining order to halt launch of generic Raloxifene

Eli Lilly and Company has issued the following statement after being granted a temporary restraining order to halt the launch of a generic version of Evista (raloxifene HCl tablets) by Teva Pharmaceuticals.

11 Mar 2009

Interventional treatment can be recommended as first-line treatment for 'silent killer'

Endovascular or endograft repair, a minimally invasive interventional radiology treatment that uses stent grafts to treat abdominal aortic aneurysms (AAA), has low re-intervention rates that are comparable to those reported for open surgical repair-and can be recommended as first-line treatment, according to a study released at the Society of Interventional Radiology's 34th Annual Scientific Meeting.

11 Mar 2009