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Study suggests Siemens non-invasive blood test may have a role in monitoring breast cancer patients' response to Herceptin

Siemens Healthcare announced that data from a new study published in the American Cancer Society journal Cancer, supports using the Siemens Serum HER-2/neu test to monitor patients with an aggressive type of metastatic breast cancer.

17 Nov 2008

New molecular insight into vertebrate brain development

In the December 1st issue of G&D, Dr. Fred H. Gage (The Salk Institute for Biological Studies) and colleagues reveal a role for the Hippo signaling pathway in the regulation of vertebrate neural development, identifying new factors - and potential therapeutic targets - that may be involved in congenital brain size disorders and neurological tumor formation.

17 Nov 2008

New gene-silencing pathway found in plants

Biologists at Washington University in St. Louis have made major headway in explaining a mechanism by which plant cells silence potentially harmful genes.

17 Nov 2008

Money worries bring on marital stress

Many couples are finding what happens in the nation's boardrooms also affects what happens - or doesn't happen - in the bedroom.

17 Nov 2008

Financial incentives motivates doctors to reduce ethnic differences in heart disease treatments

Financial incentives for doctors can improve the management of coronary heart disease (CHD) and reduce ethnic differences in quality of and access to care, according to Dr. Christopher Millett, Consultant in Public Health at Imperial College Faculty of Medicine in London in the UK, and his colleagues.

17 Nov 2008

Microarray analysis improves prenatal diagnosis

A "chip" or array that can quickly detect disorders such as Down syndrome or other diseases associated with chromosomal abnormalities proved an effective tool in prenatal diagnosis in a series of 300 cases at Baylor College of Medicine, said researchers in a report that appears in the current issue of the journal Prenatal Diagnosis.

17 Nov 2008

Scientists identify dangerous 'two-faced' protein crucial to breast cancer spread and growth

Two critical properties of cancer cells are their ability to divide without restraint and to spread away from the primary tumor to establish new tumor sites.

17 Nov 2008

Researchers reduce production of alpha-synuclein in the brain - offers hope for Parkinson's disease

Mayo Clinic researchers have developed a method to reduce the production of alpha-synuclein in the brain.

17 Nov 2008

Breakthrough reveals first ever complete structure of a nuclear hormone receptor on human DNA

For decades, scientists have been studying nuclear hormone receptors to gain a better understanding of how they turn genes on and off throughout the body and how they function as key drug targets for a number of diseases, such as diabetes, breast cancer, osteoporosis and high cholesterol. A new UVA Health System study, led by Fraydoon Rastinejad, Ph.D., professor of pharmacology and director of the UVA Center for Molecular Design and published in the October 29 issue of Nature, reveals the first ever complete structure of a nuclear hormone receptor on human DNA – a discovery that now clears a new path for scientists to design more effective drugs with fewer associated health risks. “Dr. Rastinejad’s findings fundamentally change the way people all over the world will study how nuclear hormone receptors work and introduces a new platform for designing better drugs,” says Jim Garrison, Ph.D., professor of pharmacology at UVA Health System. Nuclear hormone receptors, including the peroxisome proliferator-activated receptors (PPARs), are proteins that sit on the surface of cells and bind to specific hormones such as estrogen, progesterone and thyroid hormone. Once the receptor binds to its hormone and its DNA regulatory element, it can cause a number of alterations in the cell, switching genes on and off. These switches control the continual regulation of the metabolic system and reproductive tissues, as well as the development and differentiation of skin, bone and behavioral centers in the brain. “PPARs are widely studied because they regulate the genes that produce fat cells, glucose, insulin, lipids and metabolism,” says Dr. Rastinejad. “That’s what makes them such good drug targets for diseases like diabetes. We can design drugs more rationally to bind to the PPAR nuclear receptor complex to help regulate these functions in the body.” A number of diabetes drugs, called insulin sensitizers, have been developed based on that knowledge, but now that scientists have a clear view into how these receptors bind and what shape they take the door is wide open for the development of better drugs. "After 40 years of nuclear receptor research, we finally can view the first full and complete structure of a nuclear receptor, thanks to Dr. Rastinejad’s break-though achievement,” says Bert W. O’Malley, Ph.D., professor and chairman, Department of Molecular and Cellular Biology at Baylor College of Medicine who is widely considered a top expert in the field.

17 Nov 2008

Vitamin D deficiency may be a culprit in heart disease, high blood pressure and metabolic syndrome

The temperature might not be the only thing plummeting this winter.

17 Nov 2008

Intervention program boosts survival in breast cancer patients

A new study provides the best evidence to date that a psychological intervention program designed for breast cancer patients not only improves their health - it actually increases their chance of survival.

17 Nov 2008

Ointment made from indigo naturalis may help treat psoriasis

An ointment made from indigo naturalis, a dark blue plant-based powder used in traditional Chinese medicine, appears effective in treating plaque-type psoriasis, according to a report in the November issue of Archives of Dermatology.

17 Nov 2008

Hypertension may develop undetected in young African-American men

Young and healthy African-American men have higher central blood pressure and their blood vessels are stiffer compared to their white counterparts, signs that the African American men are developing hypertension early and with little outward sign, according to a new study.

17 Nov 2008

How is our left brain is different from our right?

Since the historical discovery of the speech center in the left cortex in 150 years ago, functional differences between left and right hemisphere have been well known; language is mainly handled by left hemisphere, while spatial recognition is more specialized to the right hemisphere.

17 Nov 2008

Cost of health insurance rises 33% with state pricing rule

New research shows that the cost of health insurance for a typical family increases about $100 per month when state governments limit price adjustments based on factors like age, health or risky behaviors such as smoking.

17 Nov 2008

Hazardous alternatives to alcohol beverages are still widely available in Russian cities

Federal restrictions on product availability have been effective but have not gone far enough, say researchers.

17 Nov 2008

One in four Gulf war veterans suffers from illness caused by toxic exposure

At least one in four of the 697,000 U.S. veterans of the 1991 Gulf War suffer from Gulf War illness, a condition caused by exposure to toxic chemicals, including pesticides and a drug administered to protect troops against nerve gas, and no effective treatments have yet been found, a federal panel of scientific experts and veterans concludes in a landmark report released Monday.

17 Nov 2008

Medical News

Study suggests Siemens non-invasive blood test may have a role in monitoring breast cancer patients' response to Herceptin

New molecular insight into vertebrate brain development

New gene-silencing pathway found in plants

Money worries bring on marital stress

Financial incentives motivates doctors to reduce ethnic differences in heart disease treatments

Microarray analysis improves prenatal diagnosis

Scientists identify dangerous 'two-faced' protein crucial to breast cancer spread and growth

Researchers reduce production of alpha-synuclein in the brain - offers hope for Parkinson's disease

Breakthrough reveals first ever complete structure of a nuclear hormone receptor on human DNA

Vitamin D deficiency may be a culprit in heart disease, high blood pressure and metabolic syndrome

Intervention program boosts survival in breast cancer patients

Ointment made from indigo naturalis may help treat psoriasis

Hypertension may develop undetected in young African-American men

How is our left brain is different from our right?

Cost of health insurance rises 33% with state pricing rule

Hazardous alternatives to alcohol beverages are still widely available in Russian cities

One in four Gulf war veterans suffers from illness caused by toxic exposure

Early detection program for men with a high prostate cancer risk

Variations within three genes associated with lipid peroxidation could increase kidney cancer risk

Four new colorectal cancer genes found

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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