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Merck ditches taranabant for obesity

Merck & Co., Inc. will not seek regulatory approval for taranabant, an investigational medicine, to treat obesity and is discontinuing its Phase III clinical development program for taranabant for obesity.

2 Oct 2008

Exelixis files investigational new drug application for anticancer compound

Exelixis, Inc. announced today that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration for XL888, a novel anticancer compound. XL888 is an orally available small molecule inhibitor of HSP90, which is a chaperone protein that promotes the activity and stability of a range of key regulatory proteins, including kinases.

2 Oct 2008

Birth size a marker of susceptibility to breast cancer later in life

The findings from a study by a team based at the London School of Hygiene & Tropical Medicine (LSHTM) are published in PLoS Medicine.

2 Oct 2008

7 million pregnant women in sub-Saharan Africa infected with hookworms

A study published by PLoS reveals that between a quarter and a third of pregnant women in sub-Saharan Africa, or almost 7 million, are infected with hookworms, putting them at risk of anaemia.

2 Oct 2008

DNA of good bacteria drives intestinal response to infection

A new study shows that the DNA of so-called "good bacteria" that normally live in the intestines may help defend the body against infection.

2 Oct 2008

Research suggests doctors should consider kidney-sparing surgery

A study of almost 1,500 kidney cancer patients treated at Memorial Sloan Kettering Cancer Center suggests that surgery to spare as much kidney tissue as possible may improve overall survival in patients who also have reduced kidney function at the time their cancer is diagnosed. The finding is significant because both kidney cancer and decreased kidney function appear to be increasing.

2 Oct 2008

Scientists identify a molecule that coordinates the movement of cells

Even cells commute. To get from their birthplace to their work site, they sequentially attach to and detach from an elaborate track of exceptionally strong proteins known as the extracellular matrix. Now, in research to appear in the October 3 issue of Cell, scientists at Rockefeller University show that a molecule, called ACF7, helps regulate and power this movement from the inside - findings that could have implications for understanding how cancer cells metastasize.

2 Oct 2008

Statin-induced muscle disorders are focus of $2.5 million in grants from NIH

Approximately 200,000 of the 38 million people in the U.S. who take statins to treat high cholesterol may develop life-threatening muscle disease.

2 Oct 2008

Raised risk of prostate cancer in Black men

Black men living in England are three times more likely to get prostate cancer than White men and tend to be diagnosed five years younger, researchers have found.

2 Oct 2008

Experts confront cancer trend: aging population, new challenges

A growing cadre of specialists - geriatric oncologists - is the latest group of medical pioneers to meet the challenge of a rising cancer incidence among older adults. They are investigating how to fill the gaps in the way oncology is practiced today, which sometimes neglects the special needs of the elderly.

2 Oct 2008

Cholesterol research, begun in the 'Little Skate,' Garners Award

New research on the way the body processes cholesterol has earned a scientist at the University of Rochester Medical Center one of the highest honors in the field.

2 Oct 2008

Kill the tobacco industry, or it will keep killing

This month in Rio de Janeiro, the global tobacco industry's annual conference features a special session on what many are seeing as its Armageddon: plain, generic packaging. All packs are identical except for the brand name, printed in standard font. No colours, no logos, no box variations. Nothing but the brand and the health warning.

2 Oct 2008

Public hearing on ways of reducing harmful use of alcohol

Each year, more than two million people die from alcohol-related causes. WHO was asked by its Member States in May at the World Health Assembly to develop a global strategy to combat the harmful use of alcohol. All parties with an interest in reducing the harmful use of alcohol are now invited to share their views in a public hearing being organized by WHO. The one-month web-based hearing will run between 3 and 31 October.

2 Oct 2008