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U.S. Patent Office confirms second of four Viread patents

Gilead Sciences, Inc. has announced that the U.S. Patent & Trademark Office (PTO) has completed the second of four reexamination proceedings and has confirmed the patentability of U.S. Patent No. 5,922,695, which covers the composition of matter for Viread (tenofovir disoproxil fumarate). On May 20, Gilead announced that the U.S. PTO confirmed the patentability of U.S. Patent No. 6,043,230.

2 Jun 2008

How advanced prostate cancer becomes resistant to androgen-deprivation therapy

For the past 70 years the treatment of choice for advanced, metastatic prostate cancer has been androgen-deprivation therapy. That is, the suppression of circulating testosterone - the hormone that fuels prostate-cancer growth - via surgical castration (orchiectomy) or medical castration with testosterone-blocking drugs. While such therapy buys time for patients, it is not a cure, as inevitably the cancer becomes resistant to the androgen deprivation and continues to grow.

2 Jun 2008

NIDA highlights best drug abuse treatment approaches at blending conference

The most difficult challenge in finding substance abuse treatment for a loved one is how to know which programs have a proven track record. That is just one of the topics being discussed today at the conference "Blending Addiction Science and Treatment: The Impact of Evidence-Based Practices on Individuals, Families and Communities." Held at the Duke Energy Center in Cincinnati, the conference is hosted by the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health. It is part of NIDA's Blending Initiative, in which teams of experts create clinical tools based on the latest treatment research.

2 Jun 2008

Survivors of childhood Hodgkin's lymphoma at higher risk of future health problems

Adults who survived childhood Hodgkin's Lymphoma should be especially vigilant about cancer and cardiovascular screenings, according to researchers from Wake Forest University Baptist Medical Center and colleagues.

2 Jun 2008

3 million now receiving anti-retroviral therapy HIV drugs

The close of 2007 marks an important step in the history of the HIV/AIDS epidemic. Nearly 3 million people are now receiving anti-retroviral therapy (ART) in low- and middle-income countries, according to a new report jointly launched today by WHO, UNAIDS and UNICEF.

2 Jun 2008

Simple infection control intervention in elementary schools reduces student absenteeism

A study from researchers at Children's Hospital Boston published in Pediatrics found that a simple infection control intervention in elementary schools - disinfecting frequently-touched surfaces and using alcohol-based hand sanitizers - helped reduce illness-related student absenteeism.

2 Jun 2008

Prevalence of pre-cancerous masses in the colon same in patients in their 40s and 50s

The prevalence of pre-cancerous masses in the colon is the same for average-risk patients who are 40 to 49 years of age and those who are 50 to 59 years of age, reports a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

2 Jun 2008

Researchers find gene signature profile for metastasis

A common signature of tiny, specific pieces of non-coding genetic material known as microRNAs (miRNAs) may be directly involved in the spread of cancer to other parts of the body.

2 Jun 2008

Short-term exposure to air pollution may increase risk of stroke or mini-stroke

Short-term exposure to low levels of particulate air pollution may increase the risk of stroke or mini-stroke, according to findings that suggest current exposure standards could be insufficient to protect the public.

2 Jun 2008

Overheating newborns can increase the risk of SIDS

New research at the University of Calgary shows that smoking while pregnant, as well as thermal stress, can lead to an increased risk of Sudden Infant Death Syndrome (SIDS). Increased ambient temperature such as over-wrapping a baby at night time or increasing the room temperature can affect the baby's pattern of breathing

2 Jun 2008

Anti-rejection drug sirolimus may prolong organ life in noncompliant kidney transplant patients

New research from the University of California, San Diego Department of Medicine, Division of Nephrology, shows that the anti-rejection drug sirolimus (brand name Rapamune) may help prolong the clinical benefit of transplanted kidneys and delay rejection, especially in patients who do not regularly take their prescribed medications (are "non-compliant"). While the transplant field has been highly successful at reducing rejection and graft loss in the first year, post-transplant, reducing risk for graft rejection in the long-term has proved more difficult.

2 Jun 2008

Protective effects of breast milk are higher in girls than in boys

Challenging the long-standing belief that breast-feeding equally protects all babies against disease, research led by Johns Hopkins Children's Center investigators suggests that when it comes to respiratory infections, the protective effects of breast milk are higher in girls than in boys.

2 Jun 2008

Waiting room touch pad device may prove to be a life-saver

Technology may be the key to identifying high-risk behaviors among adolescents. Injury risk, depressive symptoms and drug and alcohol use are the leading causes of adolescent morbidity and mortality; yet pediatricians often lack the time to screen for these behavioral concerns.

2 Jun 2008

Are bunk bed safe?

Bunk bed-related injuries are not an issue of concern solely for parents of young children according to a study conducted by investigators at the Center for Injury Research and Policy of The Research Institute at Nationwide Children's Hospital.

2 Jun 2008

Study identifies most costly adverse events in children's hospitals

A large study of health records from 38 American children's hospitals has measured adverse events that most increase length of stay and overall cost. The researchers say their findings provide useful targets for hospital programs aimed at preventing harm to young patients.

2 Jun 2008

First study to examine vitamin D insufficiency in pediatric patients with low bone density

Vitamin D insufficiency is common in adults and is emerging in the world of pediatrics. A mild degree of vitamin D deficiency, also known as vitamin D insufficiency, causes rickets in children and can be treated with increased amount of nutritional vitamin D intake as well as increased sun exposure.

2 Jun 2008

UT Southwestern mouse model mimics hyperglycemia, aids in diabetes research

UT Southwestern Medical Center researchers have genetically engineered a laboratory mouse in which pancreatic beta cells can regenerate after being induced to die. The new animal model's regenerative ability may provide future insights into improved treatments of diabetes, which affects millions of Americans.

2 Jun 2008

Potential hypophosphatasia therapy discovered

Researchers at the Burnham Institute for Medical Research, led by José Luis Millán, Ph.D., have demonstrated in mice the first successful use of enzyme replacement therapy to prevent hypophosphatasia (HPP), a primary skeletal disease of genetic origin. This discovery lays the foundation for future clinical trials for HPP patients.

1 Jun 2008

Novel chemo drug helps treat prostate cancer

Men with a certain type of prostate cancer have been shown to respond to a new chemotherapy drug, Sagopilone, plus prednisone in an international trial led by Oregon Health & Science University Cancer Institute researchers.

1 Jun 2008

US soldiers in high-tuberculosis areas face new epidemic: false positives

U.S. Army service members are increasingly deployed in regions of the world where tuberculosis (TB) is rampant, such as Iraq and Afghanistan, and the military now faces a growing medical problem. But it is not TB itself that is on the rise-instead, the problem lies with the growing number of "pseudoepidemics," or clusters of false-positives for TB that are the result of universal testing with a notoriously inaccurate tuberculin skin test (TST) and inconsistent procedures for interpreting those tests in low-risk populations.

1 Jun 2008