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Coronacept - A trap-and-destroy molecule against SARS-CoV-2

A new study published on the preprint server bioRxiv* in August 2020 reports a novel engineered molecule based on human and other mammalian orthologues of ACE2 fused with the Fc part of the antibody. This molecule interacts more tightly with the viral receptor-binding domain (RBD) to constitute a powerful immunoadhesin that targets the virus for destruction.

17 Aug 2020

Targeting SARS-CoV-2 with off-the-shelf CAR-NK cells

The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread and cause disease and death in many countries even today. At present, there is no effective treatment. A recent study published on the preprint server bioRxiv in August 2020 reports the potential of a new class of drugs called CAR NK cells, which could be used off-the-shelf to treat this disease.

17 Aug 2020

Potential inhibitors of SARS-CoV-2 identified

Now, a new study published on the preprint server bioRxiv in August 2020 reports the discovery of two inhibitors of the helicase enzyme, which is essential for viral replication and the most highly conserved non-structural coronavirus (CoV) protein.

16 Aug 2020

ARDS may not be the primary lung iInjury in COVID-19

A new Italian study published on the preprint server medRxiv in August 2020 shows that this may not be an adequate explanation, since ARDS is a nonspecific diagnosis. Instead, they say, antemortem lung biopsy shows a “Covid pattern” of acute lung injury, which could guide the application of therapeutics.

16 Aug 2020

Scientists reveal most likely order of COVID-19 symptoms

Now, a team of researchers at the University of Southern California (USC) has revealed the order of symptoms often experienced by those who infected with SARS-CoV-2. Knowing the order of the symptoms may help the patients seek medical help immediately. The research is published in the journal Frontiers in Public Health.

16 Aug 2020

U.S. scientists to create coronavirus strain for human challenge trials

Now, a team of scientists in the United States plans to create a coronavirus strain that can be used for human challenge trials, a controversial type of study wherein health volunteers would be vaccinated and intentionally infected with the virus.

16 Aug 2020

SARS-CoV-2 spike pocket is a putative target for antiviral design

In a methodologically rigorous study, researchers from the University of Oxford have recently shown how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein harbors a lipid-binding pocket which modulates the stability of the prefusion trimer and provides conformational shielding from antibodies. Their findings are currently freely available on the bioRxiv* preprint server.

16 Aug 2020

Multiphase program provides valuable lessons for advancing the fight against malaria

The intensive implementation of currently available tools to fight malaria can achieve a drastic reduction in disease burden, but is not enough to interrupt its transmission.

15 Aug 2020

New study challenges hypothesis underlying the sensitivity of mammalian auditory system

A new study from the University of Colorado Anschutz Medical Campus challenges a decades-old hypothesis on adaptation, a key feature in how sensory cells of the inner ear (hair cells) detect sound.

15 Aug 2020

Historical redlining associated with adverse birth outcomes

Past discriminatory housing practices may play a role in perpetuating the significant disparities in infant and maternal health faced by people of color in the U.S., suggests a new study by researchers at the University of California, Berkeley.

15 Aug 2020

Number of in-person health care visits not linked to COVID-19 infection in pregnant patients

In the spring of 2020, as Massachusetts experienced a surge in COVID-19 cases in the Boston area, four area hospitals conducted universal testing among all pregnant patients at the time of admission for SARS-CoV-2, the virus that causes COVID-19.

15 Aug 2020

COVID-19 crisis could offer valuable insights for climate change mitigation efforts

The dynamics of the current COVID-19 pandemic could offer valuable insights for the efforts to mitigate climate change.

15 Aug 2020

Researchers create a design schema for navigation technologies to help people with disabilities

Researchers at the University of Maryland, Baltimore County and the University of California, Irvine have collaborated to create a universal design schema for navigation technologies to better support people with disabilities in getting from place to place.

15 Aug 2020

Loughborough expert predicts how COVID-19 will impact the birth weight of babies

Being pregnant is a wonderful experience, but at the same it can be incredibly stressful - throw a global pandemic into the mix and those nine months may see an expecting mother go from happy and joyful, to fearful and concerned.

15 Aug 2020

UW team receives $33,000 grant to develop model to help lower COVID-19 infections in King County

Policymakers continue to have uncertainties on how to answer important questions about the novel coronavirus -- such as when and how to reopen businesses and schools, and how to distribute a vaccine once one becomes available.

15 Aug 2020

Infrared technology can be adapted to study infant behavior

A new study from the Beckman Institute for Advanced Science and Technology describes how existing infrared technology can be adapted to measure recognition memory and other cognitive outcomes in infants.

15 Aug 2020

Poor hygiene and antibiotic use can contribute to colonization of antimicrobial-resistant bacteria

Scientists have found clear indicators for how the interaction of poor hygiene and antibiotic use contribute to the colonization of antimicrobial-resistant (AMR) bacteria in humans, a problem that contributes to hundreds of thousands of deaths annually.

15 Aug 2020

PARP inhibitor can successfully treat a subset of advanced prostate cancer patients

Results from an international clinical trial found that men with advanced prostate cancer who have mutated BRCA1/BRCA2 genes can be treated successfully with a targeted therapy known as rucaparib, resulting in recent FDA approval.

15 Aug 2020

New discoveries could change the understanding and treatment of ovarian cancer

Recent discoveries made by researchers at Texas A&M University could change the way ovarian cancer is understood and treated.

15 Aug 2020

Frequently used serology test may not detect SARS-CoV-2 antibodies, shows study

Two different types of detectable antibody responses in SARS-CoV-2 (COVID-19) tell very different stories and may indicate ways to enhance public health efforts against the disease, according to researchers at The University of Texas MD Anderson Cancer Center.

15 Aug 2020

Medical News

Coronacept - A trap-and-destroy molecule against SARS-CoV-2

Targeting SARS-CoV-2 with off-the-shelf CAR-NK cells

Potential inhibitors of SARS-CoV-2 identified

ARDS may not be the primary lung iInjury in COVID-19

Scientists reveal most likely order of COVID-19 symptoms

U.S. scientists to create coronavirus strain for human challenge trials

SARS-CoV-2 spike pocket is a putative target for antiviral design

Multiphase program provides valuable lessons for advancing the fight against malaria

New study challenges hypothesis underlying the sensitivity of mammalian auditory system

Historical redlining associated with adverse birth outcomes

Number of in-person health care visits not linked to COVID-19 infection in pregnant patients

COVID-19 crisis could offer valuable insights for climate change mitigation efforts

Researchers create a design schema for navigation technologies to help people with disabilities

Loughborough expert predicts how COVID-19 will impact the birth weight of babies

UW team receives $33,000 grant to develop model to help lower COVID-19 infections in King County

Infrared technology can be adapted to study infant behavior

Poor hygiene and antibiotic use can contribute to colonization of antimicrobial-resistant bacteria

PARP inhibitor can successfully treat a subset of advanced prostate cancer patients

New discoveries could change the understanding and treatment of ovarian cancer

Frequently used serology test may not detect SARS-CoV-2 antibodies, shows study

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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