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Study reveals how leukemia cells evade deadly effects of BRD4 inhibitors

BRD4 inhibitors are among the most promising new agents in cancer therapy that are currently evaluated in clinical trials.

15 Sep 2015

EORTC trial evaluates effectiveness of pembrolizumab in patients with high-risk stage III melanoma

A recently opened double- blind phase III EORTC trial 1325 will prospectively assess whether post-operative adjuvant therapy with pembrolizumab, an anti-PD-1 monoclonal antibody, improves recurrence-free survival as compared to placebo in patients with high-risk stage III melanoma.

15 Sep 2015

Ex-vivo lung perfusion technique can reduce risk of transplant rejection

University of Manchester researchers have used a new technique to recondition poorly functioning lungs and remove donor white blood cells in an attempt to increase the number of lungs available for transplant, and at the same time reduce the risk of acute rejection.

15 Sep 2015

Air pollution from forest fires aggravates children’s respiratory health

Research coordinated by lecturer of the Faculty of Nursing at the University of Valencia Ferran Ballester has shown that air pollution from forest fires aggravates the respiratory health of children.

15 Sep 2015

$Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture$

Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture

Using extensive genetic data compiled by the UK10K project, an international team of researchers led by Dr. Brent Richards of the Lady Davis Institute at the Jewish General Hospital has identified a genetic variant near the gene EN1 as having the strongest effect on bone mineral density (BMD) and fracture identified to date.

15 Sep 2015

Molecular biology research holds promise in understanding cancer growth, aging

Researchers at the Johns Hopkins University have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging.

15 Sep 2015

EORTC and ESSO project provides opportunity to do prospective study on liver metastasis surgery

Is it possible to cure patients with unresectable colorectal liver metastases? Are complex surgeries safe for patients with extensive metastatic disease? How can we monitor and improve the quality of these surgical strategies? How can we improve surgical care for patients through research?

15 Sep 2015

BfArM approves Greenovation’s moss-aGal phase I clinical trial for Fabry disease

Greenovation Biotech GmbH announced today that it has received approval to begin a phase I clinical trial in Europe for its first drug candidate moss-aGal (agalsidase) from Germany's regulatory authority, the Federal Institute for Drugs and Medical Devices (BfArM).

15 Sep 2015

Sun Biomedical begins DMX-200 Phase II trial for treatment of chronic kidney disease

Sun Biomedical Limited today announced the first patient had been enrolled in a Phase II study of DMX-200, an innovative new treatment that combines two different drugs to treat chronic kidney disease.

15 Sep 2015

Prolonged sitting time, reduced physical activity contribute to non-alcoholic fatty liver disease

Prolonged sitting time as well as reduced physical activity contribute to the prevalence of non-alcoholic fatty liver disease (NAFLD) in a study of middle-aged Koreans.

15 Sep 2015

Health experts call for action to improve health and well-being of women, children, adolescents

Societies are failing women, children and adolescents, particularly in the poorest communities around the world, and urgent action is needed to save lives and improve health, say global health experts.

15 Sep 2015

New strategy improves bone repair by boosting survival rate of transplanted stem cells

Stem cell therapies are often limited by low survival of transplanted stem cells and the lack of precise control over their differentiation into the terminal cell types needed to repair or replace injured tissues. Now, a team led by Wyss Institute Core Faculty member David Mooney, Ph.D., has developed a new strategy - embedding stem cells into porous, transplantable hydrogels - that has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation.

15 Sep 2015

Researchers show how a cell surface protein can mobilize immune cells to attack malignant tumors

Revealing a biological combat strategy worthy of a five-star general, researchers from Houston Methodist Hospital, University of Chicago and Cornell University have shown how a cell surface receptor--a specialized protein which communicates signals between a cell and the outside world--can mobilize immune cells to attack, rather than protect, malignant tumors.

15 Sep 2015

Regular smokers at increased risk of tooth loss, new study confirms

A new study has confirmed that regular smokers have a significantly increased risk of tooth loss. Male smokers are up to 3.6 times more likely to lose their teeth than non-smokers, whereas female smokers were found to be 2.5 times more likely.

15 Sep 2015

Inhibition of FGFR3 receptor could be a new way of treating patients with liver cell cancer

In a recent study, scientists from the Institute for Cancer Research at MedUni Vienna have shown that the growth factor receptor FGFR3 increases the rate of growth and aggressiveness of hepatocellular carcinomas (liver cell cancer). Inhibition of this receptor could be a new and effective way of treating patients.

15 Sep 2015

Air pollution linked to overall increase in risk of death

In what is believed to be the largest, most detailed study of its kind in the United States, scientists at NYU Langone Medical Center and elsewhere have confirmed that tiny chemical particles in the air we breathe are linked to an overall increase in risk of death.

15 Sep 2015

Combining epigenetic drugs with immunotherapies may provide additional clinical benefit to cancer patients

Recent data suggest that epigenetic therapies are likely to provide additional clinical benefit to cancer patients when rationally combined with immunotherapeutic drugs, according to a review published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

15 Sep 2015

Medical News

Study reveals how leukemia cells evade deadly effects of BRD4 inhibitors

EORTC trial evaluates effectiveness of pembrolizumab in patients with high-risk stage III melanoma

Ex-vivo lung perfusion technique can reduce risk of transplant rejection

Air pollution from forest fires aggravates children’s respiratory health

Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture

Molecular biology research holds promise in understanding cancer growth, aging

EORTC and ESSO project provides opportunity to do prospective study on liver metastasis surgery

BfArM approves Greenovation’s moss-aGal phase I clinical trial for Fabry disease

Sun Biomedical begins DMX-200 Phase II trial for treatment of chronic kidney disease

Prolonged sitting time, reduced physical activity contribute to non-alcoholic fatty liver disease

Health experts call for action to improve health and well-being of women, children, adolescents

New strategy improves bone repair by boosting survival rate of transplanted stem cells

Researchers show how a cell surface protein can mobilize immune cells to attack malignant tumors

Regular smokers at increased risk of tooth loss, new study confirms

Inhibition of FGFR3 receptor could be a new way of treating patients with liver cell cancer

Air pollution linked to overall increase in risk of death

Combining epigenetic drugs with immunotherapies may provide additional clinical benefit to cancer patients

Research shows people consume more food and drink when offered larger-sized portions, packages or tableware

SunSense UK’s nationwide tour highlights the dangers of intentional tanning

Obese people may be malnourished before they undergo weight loss surgery, shows study

How real-time off-gas analysis improves fermentation process control

Advancing Drug Safety Assessment With AI, Predictive Modeling, and Human-Relevant Data

AI-powered analytics and experimental validation

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