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Researchers identify gene variant that makes breast cancer cells more aggressive

A particular human gene variant makes breast cancer cells more aggressive. Not only are these more resistant to chemotherapy but also leave the primary tumour and establish themselves in other parts of the body in the form of metastases. An international group of researchers led by Lukas Kenner of MedUni Vienna has now identified a gene, AF1q, as being substantially responsible for this and recognized it as a possible starting point for more accurate diagnosis and potential targeted therapeutic approaches.

15 Jun 2015

Combination of tosedostat and LDAC results in overall response rate of 54% in elderly patients with AML

CTI BioPharma Corp. today announced findings from an investigator-sponsored Phase 2 trial in patients with either primary (de novo) acute myeloid leukemia (AML) or AML that has evolved from myelodysplastic syndrome (MDS). Results showed the combination of tosedostat with low dose cytarabine/Ara-C (LDAC) resulted in an overall response rate (ORR) of 54 percent in elderly patients with AML – with 45 percent of patients achieving durable complete responses (CR).

15 Jun 2015

Taiho, Servier sign exclusive license agreement to develop and commercialize TAS-102 drug

Taiho Pharmaceutical Co., Ltd.(Japan) and Servier (France) announced on June 15 that they have entered into an exclusive license agreement on June 12, 2015 for the development and commercialization of TAS-102 (nonproprietary names: trifluridine and tipiracil hydrochloride) in Europe and other countries.

15 Jun 2015

Metro transit bus to become St. Louis MetroMarket's first mobile farmers market

The St. Louis MetroMarket and Saint Louis University are celebrating the delivery of a retired Metro transit bus which will soon be converted into St. Louis MetroMarket's first mobile farmers market. The bus was delivered Tuesday, June 2, to its new home at Salus Center on the Saint Louis University Med Center campus.

15 Jun 2015

Poor sleep quality increases heart disease and stroke risks

EuroHeartCare is the official annual meeting of the Council on Cardiovascular Nursing and Allied Professions of the European Society of Cardiology. The 2015 meeting is held 14 to 15 June in Dubrovnik, Croatia, in collaboration with the Croatian Association of Cardiology Nurses.

15 Jun 2015

Rising levels of carbon dioxide affect plants' absorption of nitrogen

The rapidly rising levels of carbon dioxide in the atmosphere affect plants' absorption of nitrogen, which is the nutrient that restricts crop growth in most terrestrial ecosystems. Researchers at the University of Gothenburg have now revealed that the concentration of nitrogen in plants' tissue is lower in air with high levels of carbon dioxide, regardless of whether or not the plants' growth is stimulated.

15 Jun 2015

American Thoracic Society releases recommendations on achieving good quality sleep

The American Thoracic Society has released a policy statement with recommendations for clinicians and the general public on achieving good quality sleep and getting an adequate quantity of sleep.

15 Jun 2015

$Medical guidance lacking on how to care for elderly hip fracture patients with dementia$

Medical guidance lacking on how to care for elderly hip fracture patients with dementia

Medical guidance on how to care for elderly people with dementia following a hip fracture is 'sadly lacking' according to researchers at the University of East Anglia.

15 Jun 2015

Study shows that women with endometriosis at increased risk of miscarriage, ectopic pregnancy

Women with endometriosis are at an increased risk of miscarriage and ectopic pregnancy, according to results of a huge nationwide study presented today. Moreover, women with a history of endometriosis whose pregnancies progressed beyond 24 weeks were found to be at a higher than average risk of complications, including haemorrhage (ante- and postpartum) and preterm birth.

15 Jun 2015

ABC TV's science program impacts use of statins among Australians

More than 60,000 Australians are estimated to have reduced or discontinued their use of prescribed cholesterol-lowering statin medications following the airing of a two-part series critical of statins by ABC TV's science program, Catalyst, a University of Sydney study reveals in the latest Medical Journal of Australia.

15 Jun 2015

Study examines mental health prognosis of young VTE patients

15 Jun 2015

Study shows that TNFi dose reduction strategy can help in optimal management of RA

The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) showed that, in rheumatoid arthritis (RA) patients, a good clinical response to maintenance treatment with a tumour necrosis factor inhibitor (TNFi) was maintained even when the dose was reduced by one-third.

15 Jun 2015

Spending more time in intensive physical therapy program may benefit stroke survivors

Time may heal all wounds, but in the case of stroke survivors, the key to better recovery is to spend more time in an intensive physical therapy program, according to a University of Florida Health study.

15 Jun 2015

Grand Challenges Canada commends government's leadership on maternal, newborn and child health

Grand Challenges Canada today commended the Government of Canada's sustained leadership on maternal, newborn and child health, reaffirmed by The Honourable Minister Paradis, Minister of International Development and Minister for La Francophonie.

15 Jun 2015

New evidence-based protocol to treat severe pain in emergency department patients

Simply asking the question, "Do you want more pain medication?" resulted in satisfactory pain control in 99 percent of emergency department patients participating in a study.

15 Jun 2015

Study can help VHA to target suicide prevention efforts for high-risk patients

Clinicians are challenged every day to make difficult decisions regarding patients' suicide risk. Using Veterans Health Administration health system electronic medical record data, Veterans Affairs and National Institute of Mental Health scientists were able to identify very small groups of individuals within the VHA's patient population with very high, predicted suicide risk -- most of whom had not been identified for suicide risk by clinicians.

15 Jun 2015

Primary prevention reduces mortality rates in patients with coronary heart disease

Mortality from coronary heart disease declined in Sweden from 1986 to 2002. The improvement was due mainly to a reduction in risk factors among the healthy population (primary prevention) and, to a lesser extent, treatment of people who already had developed heart disease (secondary prevention).

15 Jun 2015

Veterans who died from drug overdoses also prescribed benzodiazepines for pain

In a recent study, nearly half of all veterans who died from drug overdoses while prescribed opioids for pain were also receiving benzodiazepines, or benzos, which are common medications for the treatment of anxiety, insomnia and alcohol withdrawal. Veterans prescribed higher doses of benzodiazepines while concurrently receiving opioids were at greater risk of overdose death than those on lower doses of benzodiazepines.

15 Jun 2015

EORTC prospective registry targets patients with minimal sentinel node tumor burden in melanoma

Sentinel node biopsy is the standard staging procedure for melanoma patients, and sentinel node status is the most important prognostic factor for disease outcome in AJCC stage I/II disease. However, the therapeutic value of the sentinel node procedure followed by early completion lymph node dissection is still controversial.

15 Jun 2015

LMU clinicians reveal mechanism involved in determining lifetime of antibody-producing cells

Clinicians at Ludwig-Maximilians-Universitaet in Munich have elucidated a mechanism involved in determining the lifespan of antibody-producing cells, and identified a promising new biomarker for monitoring autoimmune diseases like multiple sclerosis and lupus erythematosus.

15 Jun 2015

Medical News

Researchers identify gene variant that makes breast cancer cells more aggressive

Combination of tosedostat and LDAC results in overall response rate of 54% in elderly patients with AML

Taiho, Servier sign exclusive license agreement to develop and commercialize TAS-102 drug

Metro transit bus to become St. Louis MetroMarket's first mobile farmers market

Poor sleep quality increases heart disease and stroke risks

Rising levels of carbon dioxide affect plants' absorption of nitrogen

American Thoracic Society releases recommendations on achieving good quality sleep

Medical guidance lacking on how to care for elderly hip fracture patients with dementia

Study shows that women with endometriosis at increased risk of miscarriage, ectopic pregnancy

ABC TV's science program impacts use of statins among Australians

Study examines mental health prognosis of young VTE patients

Study shows that TNFi dose reduction strategy can help in optimal management of RA

Spending more time in intensive physical therapy program may benefit stroke survivors

Grand Challenges Canada commends government's leadership on maternal, newborn and child health

New evidence-based protocol to treat severe pain in emergency department patients

Study can help VHA to target suicide prevention efforts for high-risk patients

Primary prevention reduces mortality rates in patients with coronary heart disease

Veterans who died from drug overdoses also prescribed benzodiazepines for pain

EORTC prospective registry targets patients with minimal sentinel node tumor burden in melanoma

LMU clinicians reveal mechanism involved in determining lifetime of antibody-producing cells

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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