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Study explores how changes in dopamine transporter function linked to brain disorders

Recent published research in the Journal of Clinical Investigation demonstrates how changes in dopamine signaling and dopamine transporter function are linked to neurological and psychiatric diseases, including early-onset Parkinsonism and attention deficit hyperactivity disorder (ADHD).

23 Jul 2014

Study reveals novel epilepsy pathway linked to neurodegenerative diseases

A recent scientific discovery showed that mutations in prickle genes cause epilepsy, which in humans is a brain disorder characterized by repeated seizures over time. However, the mechanism responsible for generating prickle-associated seizures was unknown.

23 Jul 2014

Debate heats up over physicians' skill reviews

The medical community is embroiled in a bitter debate about what board-certified physicians should be required to do to prove that their knowledge and skills are up-to-date. Besides holding a state medical license, about 75% of U.S. doctors are certified by 24 privately run boards, signifying that they have mastered their area of specialty, in fields ranging from internal medicine to orthopedics.

23 Jul 2014

Stimulating specific brain pathway may induce active emergence from anesthesia

Researchers may be one step closer to better understanding how anesthesia works. A study in the August issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists- (ASA-), found stimulating a major dopamine-producing region in the brain, the ventral tegmental area (VTA), caused rats to wake from general anesthesia, suggesting that this region plays a key role in restoring consciousness after general anesthesia.

23 Jul 2014

Study suggests possible link between immune system and schizophrenia

Nancy Buccola, MSN, APRN, PMHCNS-BC, CNE, Assistant Professor of Clinical Nursing at LSU Health Sciences Center New Orleans School of Nursing, contributed samples used in a study reporting new locations of genetic material associated with schizophrenia and also suggesting a possible link between the immune system and schizophrenia.

23 Jul 2014

Zilico receives funding to develop diagnostic device for oral cancer

Zilico Ltd has begun development work on a medical device which uses Electrical Impedance Spectroscopy (EIS) in the detection and diagnosis of oral cancer following funding from the Technology Strategy Board, the UK’s innovation agency.

From Zilico 23 Jul 2014

Novasep becomes authorized producer of new molecular entity for US market

Novasep, a leading supplier of services and technologies to the life science industries, today announces that it has successfully completed FDA (US Food and Drug Administration) pre-approval inspections carried out at two of its sites in France.

23 Jul 2014

Advaxis, MedImmune team up for immuno-oncology clinical trial

Advaxis, Inc., a clinical-stage biotechnology company developing cancer immunotherapies, has entered into a clinical trial collaboration with MedImmune, the global biologics research and development arm of AstraZeneca.

23 Jul 2014

Lancet report: Support sex workers to prevent HIV

Across the world, in high- and low-income countries, women, men, and transgender people who sell sex are subjected to repressive and discriminatory law, policy, and practice, which in turn fuel human rights violations against them, including violence and discrimination. All of these factors are preventing sex workers from accessing the services which they need in order to effectively prevent and treat HIV infection, according to a major new Series on HIV and sex workers, published in The Lancet.

23 Jul 2014

Cytoreductive nephrectomy can benefit patients with mRCC

Patients treated with targeted therapy for metastatic renal cell carcinoma may derive significant survival benefit from cytoreductive nephrectomy, particularly if their initial prognosis is good, study findings indicate.

22 Jul 2014

Marker identified for population of renal cancer cells with stem-cell-like features

Researchers have identified a population of clear cell renal cell carcinoma cells positive for the CTR2 marker that possess some stem-cell-like features and are able to induce an angiogenic response in vivo.

22 Jul 2014

Partial nephrectomy retains edge over radical nephrectomy in larger renal tumors

Patients with renal cell carcinoma tumours larger than 4 cm benefit from undergoing elective partial nephrectomy rather than radical nephrectomy surgery, a study has found.

22 Jul 2014

Alternative sunitinib treatment schedules for mRCC may be worth the switch

Some patients with metastatic renal cell carcinoma who are switched from a traditional sunitinib treatment schedule to an alternative schedule fare better on survival measures and suffer fewer adverse events, a Japanese study has found.

22 Jul 2014

Marker identified for population of renal cancer cells with stem-cell-like features

22 Jul 2014

Targeting CXCR4–CXCL12–CXCR7 axis combats mTOR inhibitor resistance in renal cancer

There is considerable crosstalk between the CXCR4–CXCL12–CXCR7 axis and the mammalian target of rapamycin pathway in human renal cell carcinoma, and targeting the axis may overcome drug resistance to mTOR inhibitors, researchers suggest.

22 Jul 2014

Oraya Therapy now being offered at NHS hospital in the UK and at four prestigious university hospitals in Germany

Oraya Therapeutics, Inc. announced today that it is significantly expanding its presence in Europe, with Oraya Therapy being offered for the first time at a National Health Service hospital in the United Kingdom and at four prestigious university hospitals in Germany. Oraya Therapy is intended as a one-time, non-invasive treatment for wet Age-related Macular Degeneration, with the potential to maintain or enhance vision while significantly reducing the required number of anti-vascular endothelial growth factor (anti-VEGF) injections into the eye.

22 Jul 2014

Liverpool School of Tropical Medicine expands support to Médecins Sans Frontières and Save the Children training schemes

Liverpool School of Tropical Medicine (LSTM) is expanding its support to the training schemes of two of the UK’s leading aid agencies: Médecins Sans Frontières/Doctors Without Borders (MSF) and Save the Children. LSTM’s expertise will enhance and recognise the Continuous Professional Development (CPD) of both agencies leading to further professionalisation of their frontline staff and improved staff retention rates.

22 Jul 2014

Exercise-induced wheezing risk increases with asthma severity

Exercise-induced wheezing is associated with the severity of asthma, according to the findings of a large, cross-sectional survey conducted in Japanese children.

22 Jul 2014

Combination superior to monotherapy for COPD

Combination treatment with umeclidinium plus vilanterol improves lung function in patients with chronic obstructive pulmonary disease to a greater extent than with VI or tiotropium monotherapy, results show.

22 Jul 2014

Long-acting inhaled combination therapy best for COPD

The combination of a long-acting β22-agonist and an inhaled corticosteroid may be the best choice for some patients with chronic obstructive pulmonary disease who need more than short-acting bronchodilators, suggest the results of a Cochrane Collaboration network meta-analysis.

22 Jul 2014