Role of asymmetric dimethylarginine in damaged blood vessels

NewsGuard 100/100 Score

A substance found naturally in the blood vessel lining is thought to contribute towards diseases associated with the circulation system, such as heart failure, high blood pressure, stroke and kidney disease.

A study to be published in the open access journal PLoS Medicine looks at the role of asymmetric dimethylarginine (ADMA), which is found in the vessel lining of healthy people but at much higher levels in those with medical conditions associated with damage to the blood vessels.

ADMA is already recognized to be an important indicator of cardiovascular disease: higher levels are found in people with a range of problems of the heart and blood vessel system. These levels have also been used to predict the risk of such problems in otherwise healthy male patients and pregnant women. However, Caroline Smith and colleagues from University College London attempted to uncover whether ADMA actually causes damage rather than just being a marker of risk. They did this by treating cells from the blood vessel lining with high doses of ADMA and measured the effects. The researchers found that a number of genes were more active when the cells were exposed to higher ADMA levels, including those that previous studies suggest are involved in lung, heart and kidney disease. The team also examined tissues from mice with high ADMA levels and found that the genes exhibiting changes were those known to be associated with cardiovascular disease and hypertension.

This exploratory research paves the way for new studies to examine the exact function that those genes responding to higher ADMA levels may play in cardiovascular disease. In the long term, understanding of the mechanisms associated with increased ADMA levels may lead to new strategies for treatment or prevention.

http://www.plosmedicine.org/

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Immune cells play a bigger role in high blood pressure than previously thought, opening doors for new treatments