Some drug mixtures may be fatal for elderly: study

British scientists warn that well known brands of hay fever tablets, painkillers and sleeping pills pose a previously unknown threat to elderly people’s health when taken together. Many are available over the counter at pharmacies as well as being prescribed by GPs, nurses and chemists they said.

Researchers from the University of East Anglia and the University of Kent identified 80 widely used medications that, when used in combination, were found to increase the risk of serious health problems. Researchers examined the medication records of more than 13,000 people aged 65 or older over two decades and found 48 per cent were using at least one of the drugs on the list.

The drugs, including common allergy treatments Piriton and Zantac, as well as Seroxat, an anti-depressant, are thought to be used by half of the 10 million over-65s in Britain. Common bladder medications, heart drugs, eye drops and asthma treatments were also among those found to pose a risk. All the drugs work by blocking a key chemical in the nervous system called acetylcholine the scientists explain.

Many of the drugs, when taken in combination, were found to more than treble an elderly patient’s chance of dying within two years. The researchers placed each of the drugs into one of three groups based on how effectively they blocked acetylcholine. The more effective the drug was in blocking the chemical the more dangerous it was in high doses.

The most dangerous included the antihistamines chlorphenamine (used in the brand Piriton) and promethazine (used in Phenergan), the anti-depressant paroxetine (used in Seroxat) and the incontinence drug oxybutynin (used in Ditropan). The heartburn drug ranitidine (used in Zantac), beta blocker Atenolol, the painkiller codeine and some eye drops were among the drugs in the mildest category.

Low-risk drugs were graded one point while high-risk drugs were graded three. The study found that patients who took a combination of drugs that added up to four points or more — such as a high-risk antihistamine combined with low-risk eye drops — had a 20 per cent chance of dying within two years, compared with just seven per cent for over-65s who did not take anything. The risk of dying increased by a further 25 per cent for each additional point accumulated, the study published in the Journal of the American Geriatrics Society, concluded.

The scientists suggest that the combination of treatments could also exacerbate dementia. In patients showing early signs of mental impairment high doses could “tip them over” into a more confused state, they said. Previous research has shown that acetylcholine-blocking drugs could have a harmful impact on the brain.

Ian Maidment, one of the researchers and a pharmacist at Kent University, said, “What is really the problem is the additive effect. It is the cumulative burden which is very damaging. It is not just the obvious medicines, it is things like heart drugs and antihistamines, and lots of doctors and nurses and pharmacists may not be aware that these medicines have this problem.” “With dementia, these drugs are particularly risky in the early stages, which we call mild cognitive impairment, where the brain is just at a tipping point. This extra insult can tip people over or worsen dementia,” he said.

Dr Chris Fox, of the University of East Anglia, said, “In the future doctors may use this tool to reduce their patient’s score below four and that’s fine, but above that is the danger area.” Dr Fox said “hundreds of thousands” of elderly people in Britain could be putting themselves at risk from the drugs but that more research was needed to explain the exact cause.

David Nutt, president of the British Neuroscience Society, said the study raised particular concerns about cheap, off-patent “tricyclic” antidepressants, such as amitryptyline, imipramine and clomipramine. They should be replaced by safer SSRI antidepressants such as fluoxetine (Prozac) and paroxetine (Paxil or Seroxat), he said.

Rebecca Wood, the chief executive of Alzheimer’s Research UK, said, “Further investigation needs to establish exactly how and why (these) drugs are increasing mortality, which might offer clues to safer drug design.”

Dr Tim Chico, an honorary consultant cardiologist at the University of Sheffield, said, “All drugs have possible side-effects, but the results of this study should not lead anyone to stop current medications without discussing this with their doctor first … it is important to balance the proven benefits against the risk of side-effects.” The report said that an increase in the use of medication in recent years meant the number of people affected could be even higher than estimated.

A spokesman for the Medicines and Healthcare products Regulatory Agency said, “Our priority is to ensure that patients are taking acceptably safe medicines. All medicines have side-effects — no effective medicine is without risk. It is important for people taking anticholinergic medicines not to stop taking them. If they have any questions or concerns then they should contact their doctor in the first instance.”

GlaxoSmithKline and Sanofi-aventis, which manufacture some of the drugs in the report, declined to comment.

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


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