ArQule, Inc. (NASDAQ: ARQL) today announced the pricing of an 
      underwritten public offering of 7,150,000 shares of its common stock at 
      a price of $7.30 per share. The net proceeds to ArQule from the sale of 
      the shares, after deducting underwriting discounts and commissions and 
      estimated expenses, are expected to be approximately $48.7 million. The 
      offering is expected to close on or about April 16, 2012, subject to 
      customary closing conditions. Citigroup and Leerink Swann are acting as 
      joint book-running managers for the offering. Lazard Capital Markets, 
      RBC Capital Markets and Oppenheimer & Co. are acting as co-managers.
    
    
      ArQule has granted the underwriters a 30-day option to purchase up to an 
      additional 1,072,500 shares of common stock. The expected net proceeds 
      to ArQule referenced above do not include any net proceeds that ArQule 
      would receive if the underwriters exercise such option to purchase 
      additional shares.