Defective potassium channels linked only with headaches, not body pain

Defective potassium channels involved in pain detection can increase the chance of developing a headache and could be implicated in migraines, according to research in mice published in eNeuro.

Defective potassium channels linked only with headaches, not body pain

A type of potassium channel called TRESK is thought to control the excitability of peripheral sensory neurons that detect pain, heat, cold, and touch. Even though these channels are found throughout the neurons sensing both body and facial pain, channel mutations are linked only with headaches and not body pain.

Yu-Qing Cao and colleagues at Washington University in St. Louis analyzed a knock-out mouse with defective TRESK channels and measured the resulting neural activity. The researchers found that only facial pain receptors were more excitable, and that the sensory neurons had more spontaneous activity. Using behavioral tests, the scientists observed that the knock-out mice showed increased sensitivity to temperature and touch stimuli on their faces, as well as more headache-related behaviors, but no body pain behaviors.

These results indicate that TRESK channels have cell-specific roles and are responsible for regulating pain in facial sensory neurons, making them a target for migraine treatment research.

Source:
Journal reference:

Guo, Z. et al. (2019) TRESK K+ Channel Activity Regulates Trigeminal Nociception and Headache. eNeuro. doi.org/10.1523/ENEURO.0236-19.2019.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Society for Neuroscience. (2019, July 19). Defective potassium channels linked only with headaches, not body pain. News-Medical. Retrieved on May 10, 2021 from https://www.news-medical.net/news/20190719/Defective-potassium-channels-linked-only-with-headaches-not-body-pain.aspx.

  • MLA

    Society for Neuroscience. "Defective potassium channels linked only with headaches, not body pain". News-Medical. 10 May 2021. <https://www.news-medical.net/news/20190719/Defective-potassium-channels-linked-only-with-headaches-not-body-pain.aspx>.

  • Chicago

    Society for Neuroscience. "Defective potassium channels linked only with headaches, not body pain". News-Medical. https://www.news-medical.net/news/20190719/Defective-potassium-channels-linked-only-with-headaches-not-body-pain.aspx. (accessed May 10, 2021).

  • Harvard

    Society for Neuroscience. 2019. Defective potassium channels linked only with headaches, not body pain. News-Medical, viewed 10 May 2021, https://www.news-medical.net/news/20190719/Defective-potassium-channels-linked-only-with-headaches-not-body-pain.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
You might also like... ×
Ketone-supplemented diet may help fight against Alzheimer’s disease