1. Chris Hartley Chris Hartley United Kingdom says:

    Anyone with even a basic knowledge of how calcitriol (activated Vit D) is created in the kidneys from calcifediol (pre-activated D3), itself created in the liver, and the length of time taken to achieve activation would be aware that taking a bolus dose of Vitamin D3 (cholecalciferol) would be ineffective in substantially altering the serum level of calcitriol in sufficient time to affect the outcome of the progression of the disease.

    The average length of time from admission to discharge seems to be 7 days, with or without administration of the bolus dose. Considering that this is less than the average time for conversion of cholecalciferol to calcitriol, should it really come as a surprise that the length of stay was unaffected? Yes, the serum level of calcifediol was increased at the time of discharge, but it needed to be raised at the time of admission.

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