Designed for those working on antibody-drug conjugate (ADC) bioanalysis, this webinar presents a practical, high-sensitivity liquid chromatography-mass spectrometry (LC-MS) workflow to support solid PK/PD decisions.
This presentation will teach you how to streamline and optimize ADC quantification with a Triple Quad mass spectrometer, using real-world examples of trastuzumab deruxtecan (TDx) in rat plasma. The speaker examines four complementary quantitative PK/PD assays, demonstrating how each delivers distinct insights about ADC behavior.
What will you get from watching?
- An overview of improved workflows for ADC quantification
- How to achieve low LLOQs for payload and peptide assays using the SCIEX 7500+ equipment
- Practical insights on assay sensitivity, repeatability, and robustness
- Enhanced awareness of how sensitive LC-MS approaches aid in drug stability, safety, and efficacy assessments
- Provide practical information on using these assays in bioanalytical procedures
This session is ideal for those wanting to enhance quantitative performance, gain confidence in low-level measurements, and develop more dependable ADC PK/PD techniques.
Who should watch?
Pharma and biopharma scientists, as well as those working in bioanalytical and PK/PD labs specializing in antibody drug conjugates and quantitative bioanalysis, will benefit from this webinar.
Presenter: Ebru Selen
Ebru received her PhD from the University of Wisconsin-Madison and did postdoctoral research at the Johns Hopkins School of Medicine, where she developed mass spectrometry and NMR methodologies for studying liver metabolism.
She works with pharmaceutical leaders at SCIEX to deploy next-generation MS technology and design innovative workflows that improve sensitivity, selectivity, and robustness in drug development.
Masterclass on comprehensive LC-MS/MS workflows for antibody drug conjugates (ADC) analysis
Learn more about SCIEX 7500+ system here >