Posted in | Mass Spectrometry

Eliminating False Positives and Negatives: Correctly Report Results the First Time


The webinar provides a detailed overview of how high-resolution mass spectrometry and data acquisition using a 'catch all compound' acquisition scan mode can reduce instances of reporting false positives and negatives.

About the TargetScreener HR – The comprehensive screening solution for complex samples

Getting it right first time

TargetScreener Workflow

Analysing complex food/water samples for drugs, pesticides, mycotoxins etc. or equally challenging human or animal urine analysis samples for poisons or drugs is a demanding application. TargetScreener HR is a powerful solution based upon accurate mass analysis and highly curated databases (over 2,000 compounds) to ensure reporting false positives (or false negatives) is minimized. Obtaining highly accurate quantitative data is also assured with TargetScreener HR.

TargetScreener HR is a complete solution covering the analysis of drugs, pesticides, PCP's et cetera which may be found in a variety of complex matrices such as food, saliva, urine, serum or environmental samples.  The solution is based upon accurate mass measurements with a Bruker QTOF system being at the centre. Added to the powerful mass spectrometer system are all components and integrated software algorithms, methods, columns and databases to allow it to work ‘out of the box’.

Typically, several hundred or thousand compounds can be screened in a single analysis with simultaneous quantitation. Hence TargetScreener is the premier solution for applications such as pesticides or other contaminants in food, animal feed or water.

When applied to forensic analysis, it is equally powerful for urine analysis or serum analysis for poisons/drug screening, workplace control for illicit drugs and doping control.

Key Reasons for Implementing TargetScreener HR

Using TargetScreener HR means that within the analytical run time of 20 minutes the system collects ‘all of the data, all of the time’ thus providing retrospective and unknown identification capabilities. Hence, if previously run samples are required to be screened for new compounds of interest then a simple operation allows this without the need to reinject the sample.

The highly curated large database provides the highest chance of eliminating false positive and false negative rates by using resolution, accurate mass, isotopic patterns, adducts and bbCID fragmentation patterns and comparing to the acquired data. The system is also highly sensitive and quantitative for use in food safety or drugs of abuse work and required legal limits of detection.

TargetScreener HR is extremely powerful for in-depth, investigative screening and quantitation as well as retrospective data mining.

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