Label-Free High-Throughput MALDI TOF Mass Spectrometry in Drug Discovery
The presentation will give a current overview of label-free high-throughput MALDI TOF mass spectrometry and its use in drug discovery screening. It will explain the basics of MALDI TOF mass spectrometry and the benefits of label-free screening compared to current labeled approaches. Data presented will focus on enzymes in the ubiquitin system (deubiquitylases, E2/E3 ligases) and protein kinases.
Professor of Proteomics at Newcastle University
Matthias studied chemistry in Freiburg, Germany and Manchester, UK. He has a PhD in Cellular Microbiology & Proteomics from the Helmholtz Centre for Infection Research, Braunschweig, Germany and was a postdoctoral fellow with Michel Desjardins at the University of Montreal, Canada and with Pierre Thibault, Institute for Research in Immunology and Cancer, Montreal, Canada. In 2010 he became Programme Leader and Head of Proteomics at the MRC Protein Phosphorylation Unit at the University of Dundee, UK. Since 2016, he is Professor of Proteomics at Newcastle University. Matthias’s research focusses on large-scale proteome and PTM analyses to understand innate immunity in macrophages. He also has a strong interest in drug discovery for which his lab developed high-throughput MALDI TOF mass spectrometry.