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Researchers discover new therapeutic target for triple-negative breast cancer

Breast cancer is categorized into three major subtypes: hormone receptor-positive, HER2-positive, and triple-negative.

29 Aug 2022

UC Davis research reveals a novel role for how tau functions in healthy nerve cells

In Alzheimer's Disease and other neurodegenerative dementias, proteins that normally play a role in healthy brain tissue turn bad, clumping together to form insoluble plaques and tangles as neurons wither and die.

25 Aug 2022

New study investigates a potential treatment for people diagnosed with monkeypox

The team behind the world-leading RECOVERY trial of COVID-19 treatments are leading a new study investigating a potential treatment for people who have been diagnosed with monkeypox.

25 Aug 2022

Immune cells preferentially use cellular waste products to power their function

The immune cells that protect us from infection and cancer seek out a wide array of fuel sources to power their function - including some long thought to be cellular waste products.

17 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN Bio 3 Aug 2022

Insights into molecular folding of AAT protein will help develop new therapies for alpha-1 antitrypsin deficiency

In a major new development in the quest to develop better gene therapies with which to treat a host of diseases, researchers at the University of Massachusetts Amherst and UMass Chan Medical School recently announced that they have mapped the expression and maturation of the protein alpha-1 antitrypsin (AAT) with unprecedented clarity.

25 Jul 2022

Researchers find link between brain protein and increased vulnerability to neurodegeneration in epilepsy patients

A team of Florida State University College of Medicine researchers has found a link between a specific protein in the brain and increased vulnerability to neurodegeneration for individuals with temporal lobe epilepsy (TLE).

18 Jul 2022

New high-throughput genomic array offers an in-depth view of the mouse epigenome

A new high-throughput genomic array offers an unprecedented look into the mouse epigenome, giving researchers an in-depth view into the basis of health and disease in a vital model organism.

13 Jul 2022

Salk professor wins $2 million to gain better understanding of cassava genetics

Research Professor Todd Michael will receive nearly $2 million from the Bill & Melinda Gates Foundation to sequence the genomes of multiple lineages of the cassava plant, a large starchy root vegetable also known as yuca root consumed in more than 80 countries around the world.

8 Jul 2022

New discovery could lead to the development of therapeutic approaches for retinitis pigmentosa

Retinitis pigmentosa, a degenerative genetic disease of the eye, is characterized by progressive vision loss, usually leading to blindness.

17 Jun 2022

Taking valproic acid during pregnancy can cause birth defects, study shows

Valproic acid - a drug used to treat epilepsy, migraine, and bipolar disorder - can cause birth defects when taken during pregnancy.

14 Jun 2022

New mouse model shows the connection between stress, depression and cardiovascular disease risk

Results from a new mouse model may aid in understanding how depression and prolonged and severe stress increase the risk of cardiovascular disease, according to preliminary research presented at the American Heart Association's Vascular Discovery: From Genes to Medicine Scientific Sessions 2022.

13 May 2022

Study reveals new approach for engineering stable articular cartilage

A new study assesses the effect of the gremlin-1 (GREM1) protein on the in vitro and in vivo stability of bone marrow stem cell (BMSC)-derived cartilage engineered within scaffolds.

29 Apr 2022

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

Combination therapy shows promise for treating triple-negative breast cancer

Researchers at Baylor College of Medicine and collaborating institutions have identified a combination therapy for treating triple-negative breast cancer (TNBC) that results in durable tumor regression in an animal model of the condition.

27 Apr 2022

Dual release microparticle system promotes cranial bone defect healing

A new dual delivery system designed to sequentially release BMP2 and IGF1 in microparticles in an injectable hydrogel successfully healed an 8-mm cranial defect in rats.

21 Apr 2022

UNIGE biologists discover a factor that explains breast cancer metastases to the bones

A team of biologists led by UNIGE has discovered, for breast cancer, a factor that explains the spread of metastases to the bones.

21 Apr 2022

Solid bone marrow aspirates may be a promising therapeutic approach for promoting wound healing

A new study compares the regenerative potential of blood/bone marrow aspirate concentrates obtained from arterial blood, venous blood, and bone marrow aspirate. The study, conducted in rabbits, is reported in the peer-reviewed journal Tissue Engineering Part A.

18 Apr 2022

Tuberculosis perturbs epigenetic processes to promote premature cellular aging

Tuberculosis (TB) is a potentially serious infectious disease caused by a type of bacterium called Mycobacterium tuberculosis.

24 Mar 2022

Study finds lesser number of female principal investigators in cardiovascular clinical trials

Despite recent efforts to improve women's leadership in cardiovascular clinical trial research over the last decade, the number of female principal investigators (PIs) still falls well below the number of males leading similar heart studies, according to a study presented at the American College of Cardiology's 71st Annual Scientific Session.

23 Mar 2022