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AI turns routine pathology slides into powerful maps of the tumor immune landscape

A large study shows that routine H&E pathology slides contain rich spatial proteomic signals that can be decoded by AI to model the tumor immune microenvironment at population scale. By generating virtual multiplex immunofluorescence images, GigaTIME enables pan-cancer discovery of immune patterns linked to invasion stage, survival, and genomic alterations.

10 Dec 2025

Triaptosis could be a promising strategy in the fight against cancer

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

10 Dec 2025

AI-driven method uncovers genetic interactions that fuel cancer progression

University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.

9 Dec 2025

Most T-cell/histocyte-rich large B-cell lymphoma patients can safely receive a less toxic treatment

Most patients with a rare and aggressive form of large B-cell lymphoma can safely receive a less toxic treatment than the intensive chemotherapy often used, according to new research from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.

8 Dec 2025

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

It's not often that a pathologist gets to make a diagnosis that works for the patient by preventing treatment from occurring.

8 Dec 2025

Integrating AI into colon cancer diagnosis improves the speed and accuracy of detection

A recent study reveals that integrating Artificial Intelligence (AI) into colon cancer diagnosis over the past five years has significantly improved the speed and accuracy of the detection of the deadly disease.

8 Dec 2025

Lower dose of immunotherapy for malignant melanoma improves results

According to a new study, lower doses of approved immunotherapy for malignant melanoma can give better results against tumors, while reducing side effects.

8 Dec 2025

Study reveals ATM kinase as the key driver of replicative senescence

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the protective caps at the chromosome ends-those caps eventually become too short to prevent chromosome ends from being recognized as DNA breaks.

1 Dec 2025

Triaptosis-based therapeutic innovations could offer renewed hope for cancer patients

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

1 Dec 2025

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Patients with the deadliest form of brain cancer, glioblastoma, who received MRI-guided focused ultrasound with standard-of-care chemotherapy had a nearly 40 percent increase in overall survival in a landmark trial of 34 patients led by University of Maryland School of Medicine (UMSOM) researchers.

24 Nov 2025

Local anesthetic lidocaine may mitigate pancreatic cancer metastasis

Pinned between the stomach and spine, the pancreas supervises both digestion and blood sugar in the body. It's also the site of an aggressive cancer called pancreatic ductal adenocarcinoma, or PDAC.

13 Nov 2025

LRIG1 could serve as important biomarker to distinguish between glioma types and grades

A new research paper was published in Oncotarget (Volume 16) on November 6, 2025, titled "LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas."

12 Nov 2025

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

The malignant pediatric brain tumor medulloblastoma is driven by proteins deep within the cancer cells, for which there are often no effective drugs available.

10 Nov 2025

Beta-blockers offer no clinical benefit for myocardial infarction survivors with preserved cardiac function

A major analysis led by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), in collaboration with international institutions, has pooled data from 17,801 myocardial infarction survivors with preserved cardiac function enrolled in five global clinical trials.

10 Nov 2025

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Cervical squamous cell carcinoma (CESC), the most prevalent subtype of cervical cancer, remains a major global health burden driven primarily by persistent high-risk HPV infection and genetic susceptibility.

7 Nov 2025

Trojan horse strategy using cesium nanosalts shows powerful anti-cancer effects

Recently, a team led by Academician Hongjie Zhang, Researcher Shuyan Song, Associate Researcher Pengpeng Lei, and Dr. Ran An at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, developed an innovative strategy to construct a series of biodegradable cesium nanosalts.

4 Nov 2025

UCLA experts call for individualized heart monitoring in breast cancer survivors

As breast cancer survival rates continue to climb - 4.3 million women in the U.S. are currently living with a history of the disease and in the next 10 years that number is expected to rise by another million - heart health has become an increasingly important part of survivorship care.

4 Nov 2025

Study highlights bioengineered models as key to early cancer detection

Scientists are exploring leading-edge technologies that could transform how cancer is studied, detected and treated by catching it earlier, when it's more treatable and survival rates are highest.

3 Nov 2025

Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression.

31 Oct 2025

Bowhead whale’s secret to long life revealed: precision DNA repair may hold clues for human aging

Researchers discovered that bowhead whales achieve extraordinary longevity and cancer resistance through highly efficient and precise DNA repair mechanisms. A whale-specific protein, CIRBP, enhances genome stability even in human cells, revealing a potential pathway to strengthen DNA repair and slow aging.

30 Oct 2025

Malignant News and Research

AI turns routine pathology slides into powerful maps of the tumor immune landscape

Triaptosis could be a promising strategy in the fight against cancer

AI-driven method uncovers genetic interactions that fuel cancer progression

Most T-cell/histocyte-rich large B-cell lymphoma patients can safely receive a less toxic treatment

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

Integrating AI into colon cancer diagnosis improves the speed and accuracy of detection

Lower dose of immunotherapy for malignant melanoma improves results

Study reveals ATM kinase as the key driver of replicative senescence

Triaptosis-based therapeutic innovations could offer renewed hope for cancer patients

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Local anesthetic lidocaine may mitigate pancreatic cancer metastasis

LRIG1 could serve as important biomarker to distinguish between glioma types and grades

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

Beta-blockers offer no clinical benefit for myocardial infarction survivors with preserved cardiac function

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Trojan horse strategy using cesium nanosalts shows powerful anti-cancer effects

UCLA experts call for individualized heart monitoring in breast cancer survivors

Study highlights bioengineered models as key to early cancer detection

Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Bowhead whale’s secret to long life revealed: precision DNA repair may hold clues for human aging

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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