Malignant News and Research

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Study explains how genetics and lifestyle combined to keep a 117-year-old healthy

Scientists conducted a multiomics study of the world’s oldest verified person (117 years), uncovering protective genetic, immune, metabolic, microbiome, and epigenetic traits that supported her exceptional longevity. These findings highlight how aging and disease may, under rare circumstances, be decoupled.

25 Sep 2025

UPR modulators show promise in treating cancer-related bone disease

Before a chain of amino acids can become an active and useful protein, it must be processed and folded into the appropriate conformation.

25 Sep 2025

Blocking iron-regulating enzyme triggers cancer cell death in multiple myeloma

Researchers at Duke University have shown that blocking an enzyme involved in iron regulation not only kills multiple myeloma cancer cells, but also increases the effectiveness of current therapies against the disease.

24 Sep 2025

New molecular signatures map the stepwise development of gastric cancer

Gastric cancer often develops through a gradual sequence of changes, beginning with superficial gastritis and advancing through chronic atrophic gastritis, intestinal metaplasia, and precancerous lesions before culminating in malignancy.

22 Sep 2025

Targeted radiation shows promise for rare solitary fibrous tumors

A novel targeted radiation approach for a rare form of malignant tumor-the solitary fibrous tumor (SFT)-has shown significant success, achieving a near-complete response in three patients.

17 Sep 2025

Tai chi improves memory and sleep in older adults with type 2 diabetes

A 12-week randomized trial found that remotely delivered Tai Chi significantly enhanced cognitive performance and sleep quality in older adults with Type 2 Diabetes. These gains surpassed those from supervised fitness walking or usual care, without increasing adverse events.

17 Sep 2025

Deep learning tool improves accuracy of lung nodule malignancy detection

An artificial intelligence (AI) deep learning tool that estimates the malignancy risk of lung nodules achieved high cancer detection rates while significantly reducing false-positive results.

16 Sep 2025

RAB26 identified as a critical regulator of prostate cancer aggressiveness

Prostate cancer (PCa) is one of the most common malignant tumors in men worldwide. While early detection has improved patient outcomes, effective therapies for advanced disease remain limited.

11 Sep 2025

Elinzanetant reduces hot flashes in menopause

The OASIS-3 trial demonstrates elinzanetant's effectiveness in alleviating menopausal symptoms, reducing hot flashes significantly over a year-long study.

11 Sep 2025

Targeting metabolic reprogramming to overcome immune suppression in head and neck cancer

Head and neck cancer remains a major global health challenge, ranking among the six most common cancers worldwide and claiming hundreds of thousands of lives each year.

5 Sep 2025

Study links hysterectomy and bilateral oophorectomy to higher stroke risk

Given the seriousness and increased frequency of strokes, many studies have been conducted to assess the relationship between hysterectomy and/or bilateral oophorectomy and the risk of stroke with varying results.

3 Sep 2025

New imaging method detects colorectal cancer using tissue autofluorescence

Colorectal cancer (CRC) is one of the most common and deadly forms of cancer worldwide. A key reason for its high death toll is that it often goes undetected until it reaches an advanced stage.

28 Aug 2025

History of traumatic brain injury tied to greater chance of malignant brain tumors

New research led by investigators at Mass General Brigham suggests a link between a history of traumatic brain injury (TBI) and risk of developing a malignant brain tumor.

25 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

Insights into the clinical presentation and management of sellar chondrosarcomas

Chondrosarcomas are a malignant form of bone cancer that is composed of cartilage-forming tumor cells. Sellar chondrosarcomas, which occur in the sellar region at the base of the skull, are a very rare manifestation of chondrosarcoma, making up only around 0.2% of all tumors found in the skull.

22 Aug 2025

Targeting a sugar metabolism pathway offers hope for treating rare and aggressive childhood cancer

A new study delving into the genetic drivers of a rare and aggressive childhood cancer called Malignant Peripheral Nerve Sheath Tumor (MPNST) has revealed metabolic frailties in the cancer cells that might be exploited to improved treatments for patients.

18 Aug 2025

Fucosylation emerges as a key player in digestive inflammatory diseases and cancers

Fucosylation, a crucial post-translational modification, has emerged as a significant factor influencing digestive inflammatory diseases and cancers.

18 Aug 2025

Advancing cancer treatment with targeted microrobotic swarms

Cancer remains one of the most challenging diseases to treat, as conventional therapies like chemotherapy and radiotherapy are often hindered by poor specificity, systemic toxicity, and damage to healthy tissues.

18 Aug 2025

Electrophysiology-based strategies enhance cancer immunotherapy

Tumor electrophysiological abnormalities, characterized by membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions, are critical drivers of malignancy.

17 Aug 2025

AI voice test could help spot dangerous throat lesions before symptoms appear

Researchers at Oregon Health and Science University found that variability in the harmonic-to-noise ratio (HNR) of speech could help distinguish benign from malignant vocal fold lesions, offering a potential early detection biomarker. The exploratory study used AI to analyze acoustic features from the Bridge2AI-Voice dataset and found differences most pronounced in male participants.

14 Aug 2025

Malignant News and Research

Study explains how genetics and lifestyle combined to keep a 117-year-old healthy

UPR modulators show promise in treating cancer-related bone disease

Blocking iron-regulating enzyme triggers cancer cell death in multiple myeloma

New molecular signatures map the stepwise development of gastric cancer

Targeted radiation shows promise for rare solitary fibrous tumors

Tai chi improves memory and sleep in older adults with type 2 diabetes

Deep learning tool improves accuracy of lung nodule malignancy detection

RAB26 identified as a critical regulator of prostate cancer aggressiveness

Elinzanetant reduces hot flashes in menopause

Targeting metabolic reprogramming to overcome immune suppression in head and neck cancer

Study links hysterectomy and bilateral oophorectomy to higher stroke risk

New imaging method detects colorectal cancer using tissue autofluorescence

History of traumatic brain injury tied to greater chance of malignant brain tumors

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Insights into the clinical presentation and management of sellar chondrosarcomas

Targeting a sugar metabolism pathway offers hope for treating rare and aggressive childhood cancer

Fucosylation emerges as a key player in digestive inflammatory diseases and cancers

Advancing cancer treatment with targeted microrobotic swarms

Electrophysiology-based strategies enhance cancer immunotherapy

AI voice test could help spot dangerous throat lesions before symptoms appear

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