Mutation News and Research

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New methodology may be important in the fight against antimicrobial resistance

NTNU has developed a promising antibiotic candidate against MRSA. Behind the discovery lies a methodology that may be important in the fight against antimicrobial resistance.

15 Dec 2023

Fetal hormone GDF15 linked to nausea and vomiting in pregnancy

Study finds that high levels of the fetal hormone GDF15 in mothers are linked to an increased risk of nausea, vomiting, and hyperemesis gravidarum in pregnancy, offering new insights into the condition's etiology.

14 Dec 2023

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

A multidisciplinary study published in Nature has elucidated the structure of the machinery responsible for writing much of our "dark genome" -; the 98 percent of our DNA that has largely unknown biological function.

14 Dec 2023

Atezolizumab plus carboplatin: A winning combination for metastatic triple-negative breast cancer

Immunotherapy in combination with chemotherapy has become an important therapeutic treatment option in some patients with metastatic breast cancer.

14 Dec 2023

Novel machine learning tool predicts gain- and loss-of-function variants across the genome

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across the genome.

14 Dec 2023

CRISPR opens doors for novel probiotic functions and applications

Humans can benefit significantly from symbiotic relationships with probiotics-;live bacteria and microorganisms that influence the gut microbiota.

13 Dec 2023

Organoid study opens new avenues in pulmonary neuroendocrine cancer therapy

Researchers performed a molecular analysis of neuroendocrine neoplasm (NEN) patient-derived tumor organoids (PDTOs) and their parental neoplasms.

13 Dec 2023

New optimized vaccine approach targets Hepatitis C virus variability

A method to design vaccines for highly variable viruses like the hepatitis C virus.

12 Dec 2023

Gene therapy shows promise for arrhythmogenic cardiomyopathy

Researchers evaluated the effectiveness of adeno-associated virus (AAV)-mediated Plakophilin 2 (PKP2) delivery in treating arrhythmogenic cardiomyopathy (ACM).

12 Dec 2023

Quizartinib extends life and enhances wellbeing for AML patients with key mutation

In a study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, patients recently diagnosed with a common and aggressive form of acute myeloid leukemia reported having improved quality of life when a newly approved drug was part of the treatment plan.

11 Dec 2023

New SARS-CoV-2 variant JN.1 shows increased transmissibility and immune resistance

A Japanese study published in BioRxiv explores the virological characteristics of the SARS-CoV-2 JN.1 variant, finding it has a higher effective reproductive number and stronger resistance to immunity from other variants, potentially due to the L455S spike protein mutation.

11 Dec 2023

Colombian family's Alzheimer's anomaly offers insights into disease pathogenesis and prevention

Alzheimer's disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life.

11 Dec 2023

Study reveals genetic roots of hodgkin lymphoma, offering hope for new treatments

A Stanford Medicine-led, international study of hundreds of samples from patients with Hodgkin lymphoma has shown that levels of tumor DNA circulating in their blood can identify who is responding well to treatment and others who are likely to experience a disease recurrence -; potentially letting some patients who are predicted to have favorable outcomes forgo lengthy treatment.

11 Dec 2023

New combinations and targeted therapies for acute myeloid leukemia on the horizon

The treatment landscape for acute myeloid leukemia (AML) is evolving rapidly, as research discoveries at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and other academic cancer centers advance new, more effective therapies for this aggressive blood cancer.

11 Dec 2023

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

A new study from researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations provides insight into the underlying mechanisms of gene mutations commonly seen in patients with myelodysplastic syndromes (MDS) and other myeloid neoplasms.

11 Dec 2023

Targeted therapy reduces markers of disease burden, improves symptoms for patients with nonadvanced system mastocytosis

The targeted therapy bezuclastinib was safe and rapidly reduced markers of disease burden while also improving symptoms for patients with a rare blood disorder called nonadvanced system mastocytosis, according to results of the Phase II SUMMIT trial reported by researchers at The University of Texas MD Anderson Cancer Center.

11 Dec 2023

Mutation News and Research

New methodology may be important in the fight against antimicrobial resistance

Fetal hormone GDF15 linked to nausea and vomiting in pregnancy

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

Atezolizumab plus carboplatin: A winning combination for metastatic triple-negative breast cancer

Novel machine learning tool predicts gain- and loss-of-function variants across the genome

CRISPR opens doors for novel probiotic functions and applications

Organoid study opens new avenues in pulmonary neuroendocrine cancer therapy

New optimized vaccine approach targets Hepatitis C virus variability

Gene therapy shows promise for arrhythmogenic cardiomyopathy

Quizartinib extends life and enhances wellbeing for AML patients with key mutation

New SARS-CoV-2 variant JN.1 shows increased transmissibility and immune resistance

Colombian family's Alzheimer's anomaly offers insights into disease pathogenesis and prevention

Study reveals genetic roots of hodgkin lymphoma, offering hope for new treatments

New combinations and targeted therapies for acute myeloid leukemia on the horizon

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

Targeted therapy reduces markers of disease burden, improves symptoms for patients with nonadvanced system mastocytosis

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

Many patients may not benefit from gene-editing treatments for sickle cell disease

Genome-wide study shows strong negative correlation between reproduction and lifespan

Groundbreaking 'Gnocchi' map reveals hidden secrets of the human genome

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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