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Discovery of gene variant could transform treatment for newborn jaundice

One in eight newborn babies has a gene variant that almost completely protects against jaundice. The research, conducted at the University of Gothenburg in Sweden, provides the opportunity to develop a treatment that can prevent severe cases of jaundice.

17 Sep 2024

Early pregnancy HbA1c predicts gestational diabetes, reducing the need for complex tests

Early pregnancy HbA1c can predict gestational diabetes and reduce the need for oral glucose tolerance tests, improving screening accessibility in diverse populations.

15 Sep 2024

Sickle cell trait increases risk of blood clots across diverse ancestries

National Institutes of Health (NIH) researchers and collaborators have found that being a carrier for sickle cell disease, known as having sickle cell trait, increases the risk of blood clots, a risk that is the same among diverse human populations that may not traditionally be associated with sickle cell disease.

12 Sep 2024

Cancer drug offers life-changing results for severe lupus patient

The team at Charité – Universitätsmedizin Berlin is astounded by the huge improvement seen in a female patient with severe systemic lupus erythematosus (SLE) after being treated with the cancer medication teclistamab. Not long ago, the 23-year-old was wheelchair-bound due to the autoimmune disease.

6 Sep 2024

Breakthrough in blood stem cell development offers hope for leukemia and bone marrow failure

Melbourne researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia and bone marrow failure disorders.

2 Sep 2024

Breakthrough vaccine targets tick-borne bovine anaplasmosis in cattle

University of Missouri researchers are working to develop the first-ever vaccine proven to protect cattle from a devastating tick-borne cattle disease known as bovine anaplasmosis.

28 Aug 2024

Benefits of less intensive stem cell transplants for sickle cell disease

So-called low-intensity blood stem cell transplants, which use milder conditioning agents than standard stem cell transplants, do not appear to damage the lungs and may help improve lung function in some patients with sickle cell disease (SCD), according to a three-year study of adults who underwent the procedure at the National Institutes of Health (NIH).

28 Aug 2024

Research unveils how HMGA2 regulates stress responses in stem cells

Kumamoto University researchers have made a groundbreaking discovery that sheds light on how the HMGA2 gene - an essential transcriptional activator involved in chromatin modification - regulates stress responses in hematopoietic stem cells (HSCs), thereby enhancing blood cell production recovery.

22 Aug 2024

Spatial transcriptomics unlocks malaria's liver stage secrets

For the malaria parasite to reach the blood of its human host, it must first enter the liver, where only a small number of parasites differentiate and replicate for upwards of seven days, making it a bottleneck in the parasite's lifecycle. This bottleneck makes the liver stage an optimal target for effective and long-lasting vaccines against the disease. Using Spatial Transcriptomics and single-cell RNA-sequencing technologies, researchers at Stockholm University have for the first time managed to create a spatio-temporal map of malaria infection in the mouse liver. A study that was recently published in Nature Communications.

21 Aug 2024

Study reveals time-of-day impact on cerebral malaria severity

A discovery by McGill-affiliated researchers could lead to more effective treatment of malaria and other parasitic diseases.

19 Aug 2024

ANU researchers develop cholesterol-based trojan horse method to target malaria parasites

More than a quarter of Australians over the age of 50 take cholesterol-lowering drugs to prevent heart disease and strokes, but our bodies also need cholesterol to survive.

13 Aug 2024

Investigational drug shows promise in treating rare blood disease in fetuses

Data from a new investigational drug that could alter the standard treatment for a rare blood disease suggests it has the potential to delay or prevent anemia and the need for intrauterine blood transfusions in babies who are at high risk for the condition, known as Hemolytic Disease of the Fetus and Newborn (HDFN).

7 Aug 2024

Decreasing folate intake can support healthier metabolisms in aging animal models

In a study published in Life Science Alliance, Texas A&M AgriLife Research scientists found that decreasing folate intake can support healthier metabolisms in aging animal models, challenging the conventional belief that high folate consumption universally benefits health.

2 Aug 2024

AI unlocks potential of antimicrobial peptides for new antibiotics

In a hopeful sign for demand for more safe, effective antibiotics for humans, researchers at The University of Texas at Austin have leveraged artificial intelligence to develop a new drug that already is showing promise in animal trials.

1 Aug 2024

Study: Iron infusions superior to blood transfusions for surgical patients with anemia

In a rigorous medical records study covering tens of thousands of patients, Johns Hopkins Medicine researchers conclude that some patients with preoperative anemia have better outcomes if they get iron infusions before surgery rather than standard red blood cell transfusions.

25 Jul 2024