Telomerase News and Research

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17 Sep 2013

Study shows that changes in diet, lifestyle choices may result in longer telomeres

A small pilot study shows for the first time that changes in diet, exercise, stress management and social support may result in longer telomeres, the parts of chromosomes that affect aging.

17 Sep 2013

Study: More than 70% of bladder tumors display somatic mutations in TERT gene

Researchers from the Spanish National Cancer Research Centre (CNIO) have discovered that more than 70% of bladder tumours display somatic mutations in the TERT gene (telomerase reverse transcriptase).

11 Sep 2013

Statins offer great potential as anti-aging therapy

Not only do statins extend lives by lowering cholesterol levels and reducing the risks of cardiovascular disease, but new research in the September 2013 issue of The FASEB Journal suggests that they may extend lifespans as well. Specifically, statins may reduce the rate at which telomeres shorten, a key factor in the natural aging process. This opens the door for using statins, or derivatives of statins, as an anti-aging therapy.

30 Aug 2013

Inovio plans to advance synthetic hTERT cancer vaccine into clinical trials in 2014

Inovio Pharmaceuticals, Inc. announced today that in a preclinical study with two animal models, Inovio's hTERT (human telomerase reverse transcriptase) DNA cancer vaccine administered with Inovio's CELLECTRA adaptive electroporation delivery technology generated robust and broad immune responses, broke the immune system's tolerance to its self-antigens, induced T-cells with a tumor-killing function, and increased the rate of survival.

24 Jul 2013

Researchers discover key role of RAP1 gene in obesity

The discovery of an unexpected function for a gene that was associated to another process in the organism might be a solution in search of a problem, a clue to unsuspected connections. That is what has happened with RAP1, a gene that protects telomeres- the ends of chromosomes-after researchers from the Spanish National Cancer Research Centre surprisingly discovered its key role in obesity.

21 Jun 2013

Researchers discover TRF1 gene that is important for nuclear reprogramming

Researchers are still fascinated by the idea of the possibility of reprogramming the cells of any tissue, turning them into cells with the capacity to differentiate into cells of a completely different type- pluripotent cells-and they are still striving to understand how it happens.

6 Jun 2013

New technique may help develop genetic thermometer to assess patients’ health

On May 22, JoVE will publish details of a technique to measure the health of human genetic material in relation to a patient-s age. The method is demonstrated by the laboratory of Dr. Gil Atzmon at New York-s Albert Einstein College of Medicine.

24 May 2013

Groundbreaking anti-aging dietary supplement

Jeunesse Global, a network marketing company that dedicates its research to promoting healthy and youthful living, has produced the solution to one of the fundamental causes of cellular aging.

23 May 2013

Long-term depression linked with life-threatening chronic disease, earlier death

The first symptoms of major depression may be behavioral, but the common mental illness is based in biology — and not limited to the brain. In recent years some studies have linked major, long-term depression with life-threatening chronic disease and with earlier death, even after lifestyle risk factors have been taken into account.

23 May 2013

Researchers find new potential target for anti-telomerase cancer therapy

Researchers at UT Southwestern Medical Center have found that alternative splicing - a process that allows a single gene to code for multiple proteins - appears to be a new potential target for anti-telomerase cancer therapy.

20 Apr 2013

Researchers create complete visual map of telomerase enzyme

Like finally seeing all the gears of a watch and how they work together, researchers from UCLA and UC Berkeley have, for the first time ever, solved the puzzle of how the various components of an entire telomerase enzyme complex fit together and function in a three-dimensional structure.

15 Apr 2013

Mindfulness meditation can reduce stress hormone

Focusing on the present rather than letting the mind drift may help to lower levels of the stress hormone cortisol, suggests new research from the Shamatha Project at the University of California, Davis.

29 Mar 2013

Research reveals immortality gene mutation plays pivotal role in brain tumors, other cancers

Newly identified mutations in a gene that makes cells immortal appear to play a pivotal role in three of the most common types of brain tumors, as well as cancers of the liver, tongue and urinary tract, according to research led by Duke Cancer Institute.

19 Mar 2013

Brandeis University researchers to receive Wiley Prize in Biomedical Sciences

Deborah E. Wiley, Chair of The Wiley Foundation, John Wiley & Sons, Inc., announced today that the twelfth annual Wiley Prize in Biomedical Sciences will be awarded to Dr. Michael Young, Rockefeller University, Dr. Jeffrey Hall, Brandeis University (Emeritus), and Dr. Michael Rosbash, Brandeis University.

1 Feb 2013

Telomerase gene mutation immortalizes deadly skin cancer

About ten percent of all cases of malignant melanoma are familial cases. The genome of affected families tells scientists a lot about how the disease develops. Prof. Dr. Rajiv Kumar of the German Cancer Research Center together with Prof. Dr. Dirk Schadendorf from Essen University Hospital studied a family where 14 family members were affected by malignant melanoma.

28 Jan 2013

Researchers identify cancer-associated mutations

Two new mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what scientists call the "dark matter" of the cancer genome, where cancer-related mutations haven't been previously found.

25 Jan 2013

Mice with reduced caloric intake accumulate longer telomeres

One of the indicators of a cell's health is the state of its DNA and containers-the chromosomes-so when these fuse together or suffer anomalies, they can become the source of illnesses like cancer and/or ageing processes.

23 Jan 2013

Scientists develop two novel model systems for human corneal endothelium

Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. Cell loss due to aging or corneal endothelial disorders, such as Fuchs dystrophy, can lead to cornea edema and blindness, resulting in the need for cornea transplants.

28 Dec 2012

New metabolic biomarkers can detect risk of illnesses in advance

One of the big challenges of biomedicine is understanding the origin of illnesses in order to improve early detection and significantly increase recovery rates, as well as being able to do what CNIO researchers call preventive molecular medicine, which consists of identifying those individuals who have a greater molecular risk of suffering certain pathologies in order to prevent them.

5 Dec 2012