in vivo News and Research

RSS

New model advances study of cardiac fibroblasts and fibrosis

Fibroblasts are an essential component of the heart, as they play key roles in its structure, development and response to cardiac damage.

15 Apr 2026

New research reveals how parasites break out of host cells

Parasites are a major global health problem, underlying many human diseases worldwide. For example, Plasmodium falciparum, the parasite responsible for malaria, plays a well-established; however, its complex life cycle is not yet fully understood.

15 Apr 2026

Targeting senescent fat cells provides new hope for ovarian cancer

Ovarian cancer is the most lethal malignancy of the female reproductive system. Due to its insidious early symptoms and the absence of specific screening modalities, approximately 70% of patients are diagnosed at an advanced stage.

13 Apr 2026

Microneedle nanoparticle platform improves lymphatic imaging with high resolution

The lymphatic system plays a critical role in pathological conditions such as lymphedema and chronic inflammation to tumor metastasis, venous insufficiency, and impaired wound healing, making accurate evaluation of its structure and function increasingly important.

13 Apr 2026

Metformin protects neurons after brain injury by restoring mitochondrial health

TBI remains a major cause of death and long-term neurological disability worldwide, yet effective treatments for secondary injury are still lacking.

13 Apr 2026

Stanford researchers create noninvasive way to deliver light deep inside the body

Light has an increasing number of applications in biology and medicine – it can be used to stimulate cell growth, manipulate neural signals, and treat some cancers – but it doesn't easily pass through tissue.

13 Apr 2026

Lab study shows cigarette smoke damaged lung cells more than e-cigarette vapor

Researchers found that cigarette smoke extract disrupted the lung cell barrier, increased IL-6 inflammation, and caused DNA damage in Calu-3 cells, while e-cigarette vapor extract showed no significant adverse effects on these measures under the study conditions. The authors caution that these were in vitro findings using liquid extracts and unflavored e-liquid, so they do not directly predict long-term human health outcomes.

12 Apr 2026

Damon Runyon supports young scientists driving cancer research innovation

The Damon Runyon Cancer Research Foundation has named 13 new Damon Runyon Fellows, exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

11 Apr 2026

Non-clinical safety assessment crucial for CRISPR-based gene therapies

The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-associated genes.

10 Apr 2026

Nanomedicine offers targeted solutions for breast cancer treatment

Breast cancer (BCA) is one of the most common cancers worldwide, with high mortality and morbidity in women.

10 Apr 2026

New hippocampus model advances understanding of Alzheimer’s progression

With a new model of the brain region essential to memory formation, from cells to whole-brain networks, the team hopes to identify critical changes in the progression of Alzheimer's disease that could point the way to earlier, more effective treatments.

9 Apr 2026

Wireless ureteral stent sleeve enables early detection of hydronephrosis

Ureteral stents are widely used to relieve obstruction and protect kidney function, but they can also become blocked, triggering hydronephrosis and prolonged elevation of intrarenal pressure that may impair renal function.

9 Apr 2026

Dynamic binding of linker histone H1 shapes flexible chromatin organization

DNA inside the nucleus is not packed as a rigid regular fiber-linker histone H1 dynamically binds and loosely "glues" nucleosomes together, creating a dynamic, fluid organization that can still support essential genome functions.

9 Apr 2026

Microplastics found in human bile may be associated with gallstones

Findings show microplastics in bile may trigger cellular senescence, suggesting a link to gallstone disease and highlighting the need for further research.

9 Apr 2026

Virica Biotech and FUJIFILM Biosciences collaborate under the Canada-Japan Co-Innovation Program to advance AAV production enhancers

Virica Biotech ("Virica"), a cell enhancer company specializing in Viral Sensitizers (VSE™) for viral vector manufacturing, today announced it is receiving advisory services and funding from the National Research Council of Canada Industrial Research Assistance Program (NRC IRAP), under the Canada-Japan Corporate Co-Innovation Program for a collaboration with FUJIFILM Biosciences.

From Virica Biotech 9 Apr 2026

Insilico Medicine nominates AI-driven drug candidate for cancer, Cushing's syndrome and obesity

The NR3C1 (nuclear receptor subfamily 3 group C member 1) gene encodes the glucocorticoid receptor (GR), a nuclear receptor vital for maintaining physiological homeostasis, and inhibition of NR3C1 could increase the sensitivity of cancer cells to standard chemotherapy, particularly in ovarian cancer.

8 Apr 2026

Clusterin inhibition offers new hope for treating cervical gastric-type adenocarcinoma

Gastric-type adenocarcinoma (GAS) is one of the most aggressive non-human papillomavirus (HPV)-associated cervical adenocarcinomas and remains especially difficult to diagnose and treat.

8 Apr 2026

Future CAR therapy expands beyond T cells to treat diverse diseases

CAR-T therapy has transformed treatment for some blood cancers, with seven FDA-approved products and strong clinical responses in hematologic malignancies.

8 Apr 2026

Xuebijing injection reduces inflammation and ferroptosis in acute lung injury

Using an LPS-induced ALI mouse model and LPS-stimulated alveolar macrophages, they found XBJ reduced inflammatory cytokine surges, preserved alveolar barrier integrity, and limited tissue injury, while probing the molecular pathways and intracellular targets underlying these benefits.

7 Apr 2026

Study questions benefits of fish oil after mild brain injuries

A first-of-its-kind study led by the Medical University of South Carolina raises questions about the value of fish oil supplements for people with repetitive mild traumatic brain injuries.

7 Apr 2026