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Researchers use machine learning to predict drug approval chances before clinical trials

Developing new drugs is paramount in discovering innovative treatments and preventing diseases. This is vital not only for advancing medicine but also for the overall health and well-being of humanity.

8 Sep 2023

New way to administer CAR-T-cell therapy could lead to fewer side effects

When Richard O'Neil, Ph.D., joined MUSC Hollings Cancer Center two years ago, he knew that he wanted to continue finding ways to make CAR-T-cell therapy easier on patients.

8 Sep 2023

Pre-clinical studies provide important first steps to prepare for first clinical bladder transplant

A series of pre-clinical studies provide important first steps in developing techniques of robotic bladder transplantation in humans, as reported in the October issue of The Journal of Urology®, an Official Journal of the American Urological Association (AUA).

8 Sep 2023

Study unveils a potential solution to combat age-related immune system decline

As we age, our bodies face numerous challenges, including a decline in immune system function and an increased vulnerability to various health issues.

7 Sep 2023

Broad-spectrum antibiotics linked to higher sepsis risk in neonates

A preprint presents evidence for the hypothesis that neonatal sepsis is linked to prenatal antibiotics.

7 Sep 2023

IU study sheds new light on the genetic underpinnings of Alzheimer's disease

A groundbreaking study led by experts from Indiana University School of Medicine has shed new light on the genetic underpinnings of Alzheimer's disease.

6 Sep 2023

Pitt neuroscientists create first non-human primate model of hereditary Alzheimer's in marmosets

To reimagine existing preclinical trials for Alzheimer's disease, University of Pittsburgh School of Medicine neuroscientists created the first non-human primate model of hereditary Alzheimer's in marmoset monkeys, outlining their approach in Alzheimer's & Dementia: Translational Research & Clinical Interventions.

6 Sep 2023

Does dahlia flower extract have anti-diabetic properties?

The effects of an extract of yellow petals of Dahlia pinnata as a novel treatment of type 2 diabetes (T2D).

6 Sep 2023

Researchers receive $2.5 million award to develop a tailored treatment for glioblastoma

A multidisciplinary team of investigators from the UCLA Jonsson Comprehensive Cancer Center was awarded a $2.5 million Translational Team Science Award from the Department of Defense to develop a tailored treatment for glioblastoma, a deadly brain tumor with limited treatment options.

5 Sep 2023

Could medicinal plants be the key to reversing cognitive decline?

Researchers explore available evidence that medicinal plants may help improve cognitive function by reducing brain inflammation.

5 Sep 2023

Gut feeling: How your microbiome could be shaping your mental health

Researchers in Biological Psychiatry delve into the complex relationship between the gut microbiome and mental health disorders like depression and bipolar disorder. The study explores how not just gut bacteria, but also lesser-known gut microorganisms such as viruses, fungi, and parasites, play a pivotal role in mood disorders.

5 Sep 2023

Study investigates the pathophysiological mechanisms of PASC after COVID-19

Researchers investigated early pathophysiological mechanisms potentially underlying PASC post-SARS-CoV-2 infection.

4 Sep 2023

Blood NfL levels correlate with severity of Alzheimer's disease pathology

Neuroscience researchers at Wayne State University published a review article that confirms the usefulness of neurofilament light (NfL) blood levels to predict the likelihood and rate of progression of neurodegeneration in Alzheimer's disease.

31 Aug 2023

Universal approach could potentially expand CAR T cell therapy to all blood cancers

A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer.

31 Aug 2023

Engineered ACE2 decoy shows promise as COVID-19 treatment

Researchers from Japan demonstrated that an engineered angiotensin-converting enzyme 2 (ACE2) receptor, which showed the potential to remarkably reduce the emergence of resistant virus strains, could successfully exert its therapeutic effect in primates, which may open avenues for the application of the technology for the treatment of humans.

30 Aug 2023

Study finds association between high dietary phosphorus and breast cancer

Researchers evaluated associations of breast cancer incidence with different dietary phosphate levels.

30 Aug 2023

Review finds correlation between milk oligosaccharides and infant brain development

In a recent article published in Nutrients, researchers investigated the current evidence of the impact of milk oligosaccharides (MOS) on early life neurocognitive and brain development.

30 Aug 2023

New drug candidate reduces inflammation and improves memory in Alzheimer's mouse models

Though drug developers have achieved some progress in treating Alzheimer's disease with medicines that reduce amyloid-beta protein, other problems of the disease including inflammation, continue unchecked.

29 Aug 2023

Inorganic nitrate reduces contrast-induced nephropathy in high-risk patients

Inorganic nitrate reduces contrast-induced nephropathy (CIN), improves renal outcomes and reduces cardiac events compared to placebo in patients at risk of renal injury undergoing coronary angiography for acute coronary syndrome, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

29 Aug 2023

Pulsed field ablation safe, effective for the treatment of paroxysmal atrial fibrillation

Pulsed field ablation (PFA) is as effective and safe as conventional thermal ablation for the treatment of paroxysmal atrial fibrillation (AF), according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

Preclinical News and Research

Researchers use machine learning to predict drug approval chances before clinical trials

New way to administer CAR-T-cell therapy could lead to fewer side effects

Pre-clinical studies provide important first steps to prepare for first clinical bladder transplant

Study unveils a potential solution to combat age-related immune system decline

Broad-spectrum antibiotics linked to higher sepsis risk in neonates

IU study sheds new light on the genetic underpinnings of Alzheimer's disease

Pitt neuroscientists create first non-human primate model of hereditary Alzheimer's in marmosets

Does dahlia flower extract have anti-diabetic properties?

Researchers receive $2.5 million award to develop a tailored treatment for glioblastoma

Could medicinal plants be the key to reversing cognitive decline?

Gut feeling: How your microbiome could be shaping your mental health

Study investigates the pathophysiological mechanisms of PASC after COVID-19

Blood NfL levels correlate with severity of Alzheimer's disease pathology

Universal approach could potentially expand CAR T cell therapy to all blood cancers

Engineered ACE2 decoy shows promise as COVID-19 treatment

Study finds association between high dietary phosphorus and breast cancer

Review finds correlation between milk oligosaccharides and infant brain development

New drug candidate reduces inflammation and improves memory in Alzheimer's mouse models

Inorganic nitrate reduces contrast-induced nephropathy in high-risk patients

Pulsed field ablation safe, effective for the treatment of paroxysmal atrial fibrillation

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