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Profound neuroinflammation associated with long COVID

Around 36 to 53% of coronavirus disease 2019 (COVID-19) patients develop persistent chronic symptoms, often referred to as long COVID or PASC.

7 Jun 2022

Age exacerbates COVID neuroimmunological symptoms

In a recent study posted to the bioRxiv* pre-print server, researchers at the University of Illinois at Chicago investigated whether aging exacerbated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-induced neuropsychiatric disorders.

6 Jun 2022

Researchers repurpose a cancer drug for the treatment of neuroinflammatory diseases

The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic.

3 Jun 2022

New, efficient protocol to generate microglia from human pluripotent cells for retinal development

This study is led by prof. Jin (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University).

3 Jun 2022

Marine organism compounds may have potential to help human fertility

Zinc-filled oysters are often linked to improved libido and sexual activity, and now scientists at Flinders University are calling for more serious investigations into how marine organism compounds can help human fertility.

3 Jun 2022

A system for detecting emerging SARS-CoV-2 variants

An article published in the journal Nature Medicine examines the unpredictable evolution of the ongoing COVID-19 pandemic.

2 Jun 2022

Novel photonic technology could enable fluorescent sensors to track molecules deep inside the body

Fluorescent sensors, which can be used to label and image a wide variety of molecules, offer a unique glimpse inside living cells.

30 May 2022

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Researchers identified 10-40, a human monoclonal antibody with potent neutralizing activity against SARS-CoV, SARS-CoV-2, and related sarbecoviruses.

30 May 2022

Exploring virological profiles of recently emerged SARS-CoV-2 Omicron variants

Researchers explored the virological profiles of novel SARS-CoV-2 Omicron variants.

30 May 2022

Researchers evaluate atovaquone as a COVID-19 treatment

Researchers evaluated a drug, atovaquone, for COVID-19 treatment.

30 May 2022

Using diffusion-weighted MRI to visualize brain inflammation in vivo for the first time

Research of the laboratories led by Dr. Silvia de Santis and Dr. Santiago Canals, both from the Institute of Neurosciences UMH-CSIC (Alicante, Spain), has made it possible to visualize for the first time and in great detail brain inflammation using diffusion-weighted Magnetic Resonance Imaging.

27 May 2022

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

Researchers compared the polymer-nanoparticle hydrogel system and standard routes of delivery of broadly neutralizing antibodies against SARS-CoV-2 in a mouse model.

27 May 2022

Scientists discover a gene defect that results in allergic and autoimmune disease

Inflammation of the skin and the esophagus, food allergy and asthma are just some of the symptoms of a now 12-year-old boy who was the first to have a mutation on the IL-33 gene. An international team led by a physician from the Karl Landsteiner University for Health Sciences, Krems, discovered this new disease entity.

26 May 2022

The role of pyroptosis in COVID-19

Researchers investigate the mechanisms by which SARS-CoV-2 induces NLRP3 inflammasome formation leading to pyroptosis.

25 May 2022

New imaging approach helps scientists build a complete picture of brain networks

Researchers at the Francis Crick Institute have developed an imaging technique to capture information about the structure and function of brain tissue at subcellular level – a few billionth of a metre, while also capturing information about the surrounding environment.

25 May 2022

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Small interfering RNAs, or siRNAs, hold promise to treat tumors, through their ability to specifically knock down oncogenes that promote tumor growth, without the toxicity that accompanies chemotherapy. However, the siRNAs need a delivery vehicle to protect them from degradation and clearance on their journey through the bloodstream to the cancer tumor.

25 May 2022

Insilico Medicine nominates novel preclinical candidate targeting 3CL protease for COVID-19 treatment

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced its nomination of a novel preclinical candidate (PCC) targeting 3C-like (3CL) protease for the treatment of COVID-19.

24 May 2022

Novel ultrasound-assisted laser technique removes arterial plaque safely and efficiently

Atherosclerosis, a buildup of plaque, can lead to heart disease, artery disease, and chronic kidney disease and is traditionally treated by inserting and inflating a balloon to expand the artery.

24 May 2022

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Researchers assessed the neutralization efficacy of a saRNA vaccine targeting SARS-CoV-2 S protein against reinfection among hamsters with prior vaccination or infection.

24 May 2022

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

In a recent study posted to the medRxiv* preprint server, investigators in Singapore showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection elicited broadly specific virus-selective nasal resident CD8 and CD4 T cells.

24 May 2022

in vivo News and Research

Profound neuroinflammation associated with long COVID

Age exacerbates COVID neuroimmunological symptoms

Researchers repurpose a cancer drug for the treatment of neuroinflammatory diseases

New, efficient protocol to generate microglia from human pluripotent cells for retinal development

Marine organism compounds may have potential to help human fertility

A system for detecting emerging SARS-CoV-2 variants

Novel photonic technology could enable fluorescent sensors to track molecules deep inside the body

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Exploring virological profiles of recently emerged SARS-CoV-2 Omicron variants

Researchers evaluate atovaquone as a COVID-19 treatment

Using diffusion-weighted MRI to visualize brain inflammation in vivo for the first time

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

Scientists discover a gene defect that results in allergic and autoimmune disease

The role of pyroptosis in COVID-19

New imaging approach helps scientists build a complete picture of brain networks

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Insilico Medicine nominates novel preclinical candidate targeting 3CL protease for COVID-19 treatment

Novel ultrasound-assisted laser technique removes arterial plaque safely and efficiently

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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