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UCLA researchers discover new way to eliminate leukemia stem cells

The introduction of the drug imatinib in 2001 revolutionized the treatment of a type of cancer called chronic myelogenous leukemia. In more than 80% of people with CML who received the drug, the disease went into complete remission.

15 Oct 2019

Research reveals increased inflammatory activity in patients with frontotemporal dementia

Recent research from the University of Eastern Finland revealed increased inflammatory activity in a subgroup of patients with frontotemporal dementia. Increased inflammation was associated with parkinsonism symptoms and more rapid disease progression.

15 Oct 2019

Researchers reveal mechanism involved in altering DNA methylation in cancer

Understanding the mechanisms that mediate widespread DNA damage in the cancer genome is of great interest to cancer physicians and scientists because it may lead to improved treatments and diagnosis. In this study, a multi-institutional team led by researchers at Baylor College of Medicine has brought attention to genomic structural variation as a previously unappreciated mechanism involved in altering DNA methylation, a form of gene control, in human cancers.

15 Oct 2019

Study suggests new model of treatment for heart attack or stroke victims

Each year, heart attacks kill almost 10 million people in the world, and more than 6 million die from stroke. A heart attack is caused by a clot that blocks the artery blood flow. Unirrigated tissues are deprived from the oxygen that is carried by the blood. Under these conditions, the affected tissues undergo a rapid necrosis.

15 Oct 2019

Discovery could lead to new therapeutic targets for neurodegenerative diseases

Research led by Drs. Miguel Burguillos (University of Seville, Spain) and Miguel Branco (Queen Mary University of London, UK), has revealed new findings about mechanisms regulating brain inflammation which open a new pathway in the field of neuroinflammation.

15 Oct 2019

Simpler and direct method for producing lipidated proteins

Some of the body's proteins are not just made up of amino acids, they are also 'decorated' with lipid chains, which significantly influence the biological functions of the protein.

15 Oct 2019

Antibody-based eye drops show promise in treating dry eye disease

Dry eye is a condition wherein a person doesn’t have enough tears to lubricate the eye. With the chronic lack of sufficient lubrication, moisture, and nourishment on the eye, it can lead to eye irritation, inflammation, and eventually, scarring.

14 Oct 2019

Ludwig scientists develop robust method to refine personalized cancer immunotherapy

Ludwig Cancer Research scientists have developed a new and more accurate method to identify the molecular signs of cancer likely to be presented to helper T cells, which stimulate and orchestrate the immune response to tumors and infectious agents.

14 Oct 2019

New Penn Medicine study unravels the early makings of an exhausted T cell

The immune system struggles to defeat cancer or chronic infections because many of the T cells that leap into action end up "exhausted," rendering them ineffective against disease.

14 Oct 2019

Committee calls for cheese products to display warning about breast cancer

The Physicians Committee for Responsible Medicine has called for the Food and Drug Administration (FDA) to push for cheese manufacturers to place breast cancer warning labels on their products.

14 Oct 2019

Diet a significant factor in acne outbreaks, finds pioneering new study

An unhealthy diet, a high level of stress, and extreme skincare routines were the most significant factors related to acne breakouts.

14 Oct 2019

Poor paternal diet may impact the heart health of offspring

When trying to get pregnant, couples often change their lifestyles, going on crash diets or taking up stricter exercise regimens. New research, done on mice, suggests that men might be best off avoiding crash diets, as it may affect the heart health of their offspring.

14 Oct 2019

Rotavirus plays role in development of type 1 diabetes

A new article published in the journal PLOS Pathogens on October 10, 2019, claims that the common rotavirus may be responsible for the occurrence of type 1 diabetes, a form of diabetes which occurs in children and is due to destruction of the pancreatic islet cells that produce the hormone insulin to normalize blood glucose levels.

13 Oct 2019

Brain protein plays a prominent role in the maintenance of chronic pain

A protein called RGS4 (Regulator of G protein signaling 4) plays a prominent role in the maintenance of long-term pain states and may serve as a promising new target for the treatment of chronic pain conditions, according to research conducted at the Icahn School of Medicine at Mount Sinai and published in print October 16, in The Journal of Neuroscience.

11 Oct 2019

Antibody-based eye drop treatment reduces signs and symptoms of dry eye disease

Researchers at the University of Illinois at Chicago are the first to identify the presence of a specific type of antibody, called anti-citrullinated protein autoantibodies, or ACPAs, in human tear fluid.

11 Oct 2019

SOX9 broadly modifies the severity of Alagille syndrome liver disease in mice

Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and other tissues.

11 Oct 2019

Repurposed quinacrine can reduce tumor burden in mice bearing HNSCC xenograft tumors

The authors have developed the Accelera TED platform to repurpose drugs for HNSCC treatment; using in vitro assays and in vivo models.

11 Oct 2019

Blood test can improve diagnosis and monitoring of aortic aneurysms

It is the 'silent killer' that claimed the life of Albert Einstein and affects 1% of men over the age of 65, but researchers at the University of Dundee believe they may be able to reduce the number of fatalities caused by abdominal aortic aneurysms.

11 Oct 2019

Research finds drugs for better long-term treatment of poorly controlled asthma

The waning effectiveness of drugs over time continues to be a major challenge in treating diseases, including asthma.

11 Oct 2019

€7.6 million ERC Synergy grant to support research on molecular mechanisms of viral infection

The interdisciplinary team wants to investigate the molecular mechanisms of viral infection, which will contribute to fundamental knowledge about cellular regulation and new concepts for broad-spectrum anti-viral therapy. The funding amounts to 7.6 million euros.

11 Oct 2019