Poor paternal diet may impact the heart health of offspring

When trying to get pregnant, couples often change their lifestyles, going on crash diets or taking up stricter exercise regimens. New research, done on mice, suggests that men might be best off avoiding crash diets, as it may affect the heart health of their offspring.

While much research has shown the effects of maternal health on the offspring, very little is known about the impact of the father’s health. A study from researchers at the University of Nottingham published today in The Journal of Physiology shows that poor paternal diet, specifically low in protein, may impact the heart health of the offspring by changing their seminal fluid, which bathes sperm.

The researchers looked at the effect of low protein diets on both the sperm and seminal fluid of male mice. They studied the impact on offspring in four conditions: when the sperm was from a dad with a poor diet, when the seminal fluid was, when both were, and when neither was. They found that the heart health of offspring was negatively impacted when there was mismatch between the sperm and seminal fluid, meaning that one was from a poor dietary dad and the other from a dad with a normal diet, or vice versa.

Men on crash diets may be affected, as the quality of seminal fluid changes quickly, while sperm only changes after a few months, meaning that there might be a mismatch in the first few months of a diet, and this time may coincide with when they are trying to conceive.

These findings may have also implications for couples using assistive reproductive technologies such as IVF because IVF uses only the sperm, and this might result in a mismatch between the quality of sperm and seminal fluid.

Adam Watkins, senior author on the study said:

It is important that we understand how and why paternal diet impacts on the offspring, so we can suggest preventative measures for couples who are trying to conceive, such as dietary recommendations.”

Journal reference:

Watkins, A., et al. (2019) Paternal Diet Impairs F1 and F2 Offspring Vascular Function Through Sperm and Seminal Plasma Specific Mechanisms in Mice. The Journal of Physiology. doi.org/10.1113/JP278270.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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