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Metabolic reprogramming drives prostate cancer progression and treatment resistance

Prostate cancer (PCa) is one of the most common malignant tumors among men worldwide. Following androgen deprivation therapy (ADT), the disease often progresses to castration-resistant prostate cancer (CRPC).

24 Jan 2026

Genetic study links vitamin B1 metabolism to gut motility and IBS risk

Research links thiamine metabolism to gut motility, identifying genetic markers that could lead to new therapies for IBS and related digestive disorders.

23 Jan 2026

Ageing slows brain protein clearance and shifts synaptic waste to microglia

Ageing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.

22 Jan 2026

Nearly half of adults now live with heart disease as obesity and diabetes surge

The 2026 American Heart Association Heart Disease and Stroke Statistics report shows that nearly half of adults are living with cardiovascular disease, with cardiometabolic risk factors projected to rise substantially by 2050. Despite progress in smoking reduction and cholesterol control, worsening obesity, diabetes, hypertension, sleep health, and persistent inequities threaten future cardiovascular health.

22 Jan 2026

Exercise variety, not just volume, is tied to longer life

Researchers analysed nearly three decades of data from more than 111,000 adults to examine whether the variety of physical activities people perform is linked to long-term survival. They found that engaging in a broader range of activity types was associated with lower all-cause mortality, independent of total exercise volume.

22 Jan 2026

When you eat matters: early time-restricted eating improves metabolic health

Time-restricted eating improves several metabolic outcomes compared with usual diets, with benefits observed for body weight, adiposity, blood pressure, insulin, glucose, and triglycerides. Early eating windows consistently outperform late eating, while the optimal duration of food intake remains uncertain.

22 Jan 2026

Regular aerobic exercise slows a key marker of brain aging in midlife

Regular aerobic activity significantly reduces brain-PAD, indicating that exercise is crucial for maintaining brain health and reducing dementia risk.

22 Jan 2026

Sperm RNA aging shift that may explain paternal age effects

Study reveals an 'aging cliff' in sperm RNA, linking age-related changes to early development and highlighting risks associated with advanced paternal age.

22 Jan 2026

A routine blood test may reveal who is most at risk of osteoporosis

A routine creatinine blood test may identify individuals at higher risk for osteoporosis and fractures, highlighting its potential as a risk assessment tool.

22 Jan 2026

Long-term air pollution exposure raises motor neuron disease risk

Long-term exposure to ambient air pollution was associated with a higher risk of developing motor neuron disease and poorer prognosis after diagnosis in a large nationwide Swedish study. Higher particulate matter and nitrogen dioxide exposure were also linked to faster functional decline and increased likelihood of invasive ventilation.

21 Jan 2026

Shingles vaccination is linked to slower biological aging in older adults

This population-based study of U.S. adults aged 70 and older found that shingles vaccination was associated with slower epigenetic and transcriptomic aging, as well as lower systemic inflammation. No significant associations were observed for neurodegeneration or cardiovascular biomarkers, highlighting domain-specific molecular effects rather than broad clinical changes.

21 Jan 2026

Wearable AI device turns silent throat signals into fluent speech for stroke patients

AI technology in a wearable choker helps stroke survivors overcome communication barriers by transforming throat vibrations into clear, context-aware speech.

21 Jan 2026

Blood lipid–hormone ratios predict future asthma attacks years in advance

This study shows that specific ratios of circulating sphingolipids to steroids can predict the risk of future asthma exacerbations over five years with high discriminatory performance. By integrating metabolomics with longitudinal medical records, the research highlights lipid–hormone pathway imbalance as a key driver of asthma instability.

20 Jan 2026

High-dose flu shots lower hospitalization risk in older adults

High-dose influenza vaccines may lower serious hospitalization rates in older adults, particularly those with diabetes, according to a recent Danish trial.

20 Jan 2026

Adding lean pork to a plant-forward diet supports healthy aging biomarkers

A randomized crossover feeding trial in adults aged 65 years or older found that plant-forward diets incorporating either minimally processed lean pork or lentils produced similar short-term improvements in cardiometabolic and neuroactive biomarkers. Both diets supported metabolic health and functional stability, with no overall adverse biomarker effects attributable to including minimally processed red meat within a Dietary Guidelines–aligned pattern.

19 Jan 2026

PFAS exposure increases gestational diabetes risk

A review of 130 studies links PFAS exposure to gestational diabetes, highlighting the need for further research on diabetes outcomes and environmental factors.

19 Jan 2026

Alcohol-free drinks may reduce harm, if marketing loopholes stop

The BMJ review warns that unregulated alcohol-free drinks may widen inequalities and undermine effective alcohol control, emphasizing the need for caution.

19 Jan 2026

Ashwagandha aids recovery without blunting training stress in athletes

Six weeks of Ashwagandha root extract supplementation in semi-professional team-sport athletes was associated with sex-specific effects during pre-season training. Females showed improved perceived recovery with stable cortisol, while males demonstrated gains in lower-body power with stable cortisone levels.

18 Jan 2026

PSA-based tool improves decision making for prostate cancer screening and treatment

Prostate cancer is the second-leading cause of cancer death in American men.

16 Jan 2026

Study tests combined targeted radiopharmaceuticals and precision radiation for recurrent prostate cancer

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have opened a clinical trial that will look at whether combining precision radiation with a targeted radioactive therapy drug can help patients with recurrent prostate cancer delay progression, while delaying or avoiding the side effects of long-term hormone therapy.

16 Jan 2026