Clinical Trial News and Research

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Weight loss drug semaglutide may offer relief for knee arthritis pain

Semaglutide shows promise in treating knee osteoarthritis by reducing pain and weight, offering a safe alternative to traditional pharmacological interventions.

4 Nov 2024

Weight stigma hinders effective treatment for women with PCOS

Lifestyle management in polycystic ovary syndrome (PCOS) needs to reduce weight stigma, because for some people living with it, overly focusing on weight loss can negatively impact their mental health and wellbeing, a Monash University-led systematic review has found.

4 Nov 2024

Combination therapy shows promising results in treating stage 3 melanoma

Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI).

1 Nov 2024

Virtual yoga program shows promise for chronic low back pain relief

Cleveland Clinic researchers found that a 12-week therapeutic virtual yoga program for chronic low back pain can be a feasible, safe and effective treatment option. The findings are published in JAMA Network Open.

1 Nov 2024

Iron supplements may boost brain development in children with HIV

A University of Minnesota Medical School research team has found that giving iron supplements to children living with human immunodeficiency virus (HIV) in sub-Saharan Africa could be an important first step in optimizing brain development.

1 Nov 2024

Two topical treatments show similar benefits for photoaging of the hands

Topically applied products containing human platelet extract or vitamin C provide similar improvements in age spots (photoaging) of the hands, as reported in a clinical trial within the November issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

1 Nov 2024

Heart attack triggers sleep increase to aid recovery

A heart attack can trigger a desire to get more sleep, allowing the heart to heal and reduce inflammation - and this happens because the heart sends special signals to the brain, according to a new Mount Sinai study.

1 Nov 2024

Study reveals effective combination therapy to slow cognitive decline in older adults

An important new study led by the Centre for Addiction and Mental Health (CAMH), and with partnership across several Toronto Dementia Research Alliance (TDRA) sites - Baycrest, Sunnybrook Health Science Centre, Unity Health Toronto, and University Health Network - has demonstrated that a combination therapy can slow cognitive decline in older adults at risk for dementia.

1 Nov 2024

Weill Cornell Medicine professor receives major grant for pediatric pain management study

Dr. Chani Traube, the Gerald M. Loughlin, MD Professor of Pediatrics at Weill Cornell Medicine, has been awarded a $3.4 million grant, with the possibility of extending to a total of $17 million over five years, from the National Institutes of Health, for a large-scale clinical trial called Optimizing Pain Treatment in Children on Mechanical ventilation (OPTICOM).

1 Nov 2024

Semaglutide reduces urine albumin-to-creatinine ratio in overweight chronic kidney disease patients

Researchers investigate the clinical efficacy of semaglutide in controlling urine albumin-to-creatinine ratio in overweight patients with chronic kidney disease.

31 Oct 2024

Study reveals cost-effective benefits of treating depression in low-income countries

Treating people in low-income countries for major depressive disorder can also help improve their physical health and household members' wellbeing, demonstrating that mental health treatments can be cost effective, according to a new RAND study.

30 Oct 2024

Study links ketogenic diet to improved menstrual health

Increasing ketones in the blood through a keto diet or supplements may help put irregular menstrual cycles back on schedule or even restart a period that appears to have stalled for good, new research suggests.

30 Oct 2024

Vitamin K2 reduces the frequency, intensity, and duration of nighttime leg cramps

A study reveals vitamin K2 significantly lowers the frequency and intensity of nocturnal leg cramps in individuals over 65, enhancing symptom management.

30 Oct 2024

Researchers develop new approach to predict immunotherapy response in breast cancer patients

Using computational tools, researchers from the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a method to assess which patients with metastatic triple-negative breast cancer could benefit from immunotherapy.

29 Oct 2024

AI-powered avatars set for mental health trials in India and Ethiopia

AI-powered digital avatars are to be trialled for people in India and Ethiopia who hear voices in their heads, as researchers try to adapt mental health treatment so they can be used effectively in low-resource settings.

29 Oct 2024

Study reveals AI's potential and pitfalls in medical diagnosis

Published in JAMA Network Open, a collaborative team of researchers from the University of Minnesota Medical School, Stanford University, Beth Israel Deaconess Medical Center and the University of Virginia studied how well doctors used GPT-4 - an artificial intelligence (AI) large language model system - for diagnosing patients.

28 Oct 2024

Ozempic effective for patients with chronic kidney damage

In a 24-week trial, semaglutide led to a 52% reduction in albuminuria and improved kidney health in individuals with chronic kidney disease and obesity.

28 Oct 2024

Clinical trial highlights efficacy of imlifidase for kidney transplant recipients

For kidney transplant recipients experiencing antibody-mediated rejection, the current standard of care involves removing donor-specific antibodies (DSAs) through plasmapheresis (PLEX) - a procedure that removes antibodies from the plasma portion of the blood.

27 Oct 2024

New analysis confirms canagliflozin's cardiovascular and kidney benefits in older adults

Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients' age.

26 Oct 2024

Diabetes drug semaglutide proves beneficial for patients with chronic kidney damage and obesity

The diabetes drug semaglutide, also known as Ozempic, has a positive effect for patients with chronic kidney damage and obesity. They

26 Oct 2024

Clinical Trial News and Research

Weight loss drug semaglutide may offer relief for knee arthritis pain

Weight stigma hinders effective treatment for women with PCOS

Combination therapy shows promising results in treating stage 3 melanoma

Virtual yoga program shows promise for chronic low back pain relief

Iron supplements may boost brain development in children with HIV

Two topical treatments show similar benefits for photoaging of the hands

Heart attack triggers sleep increase to aid recovery

Study reveals effective combination therapy to slow cognitive decline in older adults

Weill Cornell Medicine professor receives major grant for pediatric pain management study

Semaglutide reduces urine albumin-to-creatinine ratio in overweight chronic kidney disease patients

Study reveals cost-effective benefits of treating depression in low-income countries

Study links ketogenic diet to improved menstrual health

Vitamin K2 reduces the frequency, intensity, and duration of nighttime leg cramps

Researchers develop new approach to predict immunotherapy response in breast cancer patients

AI-powered avatars set for mental health trials in India and Ethiopia

Study reveals AI's potential and pitfalls in medical diagnosis

Ozempic effective for patients with chronic kidney damage

Clinical trial highlights efficacy of imlifidase for kidney transplant recipients

New analysis confirms canagliflozin's cardiovascular and kidney benefits in older adults

Diabetes drug semaglutide proves beneficial for patients with chronic kidney damage and obesity

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