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A digital twin for your immune system

In a recent study posted to the NPJ Digital Medicine journal, researchers illustrated a framework for constructing digital twins of the human immune system.

23 May 2022

UAB researchers track the behavior of microplastics inside a living organism

A UAB research team has managed to track the behavior of microplastics during their "journey" through the intestinal tract of a living organism and illustrate what happens along the way.

23 May 2022

Tiny shark-derived antibodies broadly neutralize most SARS-CoV-2 variants

Resarchers discuss the ability of shark-derived antibodies to protect against multiple variants of SARS-CoV-2.

23 May 2022

Can human coronaviruses infect the GI tract?

Researchers review current findings on how human coronaviruses like SARS-CoV-2 might cause GI symptoms.

22 May 2022

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5.

20 May 2022

Ensitrelvir demonstrates swift SARS-CoV-2 clearance and safety among individuals with asymptomatic, mild, or moderate SARS-CoV-2 infections

Researchers reported findings that assessed the safety and efficacy of Ensitrelvir among patients with asymptomatic or mild-to-moderate SARS-CoV-2 infection in Japan.

20 May 2022

Glaucoma treatment using smart contact lenses that release drugs

In a recent study published in the journal Nature Communications, researchers developed a wireless theranostic contact lens (WTCL) sensor for sensing intraocular pressure (IOP) in situ and delivering anti-glaucoma drugs on-demand.

19 May 2022

Kyunurenic acid in cardiovascular therapy

In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of kynurenic acid on ischemic damage to the heart.

19 May 2022

SARS-CoV-2 zoonotic transmission prediction using ACE2 receptor variation is limited

In a recent study posted to the bioRxiv* preprint server, researchers at the University of Glasgow assessed the variation in angiotensin-converting enzyme 2 (ACE2) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host prediction.

19 May 2022

Potential therapeutic target discovered for pancreatic ductal adenocarcinoma tumors

Northwestern Medicine investigators have discovered a potential therapeutic target for the most common type of pancreatic cancer, according to a study published in Developmental Cell.

19 May 2022

Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model.

18 May 2022

Study explores lipid nanoparticles against SARS-CoV-2

Researchers assessed the efficiency of lipid nanoparticles against SARS-CoV-2.

18 May 2022

Insight into sustained-release drug delivery systems

In this interview, News-Medical speaks to Thanh T. Nguyen, a project manager at Innocore Pharmaceuticals, about the mechanisms behind long-acting injectables.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 18 May 2022

Exosomes derived from γδ-T cells synergized with radiotherapy can control nasopharyngeal carcinoma

A research team at LKS Faculty of Medicine, The University of Hong Kong discovered that exosomes derived from γδ-T cells (γδ-T-Exos) synergised with radiotherapy can control nasopharyngeal carcinoma (NPC) by overcoming the radioresistance of NPC cancer stem cells (CSCs) and preserve their tumor-killing and T cell-promoting activities in the immunosuppressive NPC microenvironment.

18 May 2022

Study reveals how the brain volume changes in Parkinson's patients

Researchers of the Human Brain Project (HBP) found that in Parkinson’s disease the volumes of certain brain regions decrease over time in a specific pattern that is associated with clinical symptoms and largely coincides with the pattern described in Braak’s famous staging theory.

17 May 2022

Mice live longer with nasal gene therapy

In a recent study published in the Proceedings of the National Academy of Sciences journal, researchers assessed the efficiency of a novel intranasal and injectable therapy in improving life expectancy.

17 May 2022

Broad-spectrum polymeric antivirals against SARS-CoV-2

In a recent study published in the journal Advanced Science, researchers evaluated the potential and applicability of macromolecular viral inhibitors against respiratory viral pathogens.

17 May 2022

Characterizing SARS-CoV-2 non-structural protein 15 endoribonuclease variants

In a recent study posted to the bioRxiv* pre-print server, researchers characterized the mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 15 (Nsp-15).

16 May 2022

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals

13 May 2022

Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

Researchers created polystyrene sulfonate with significantly different molar masses, constructed these polymers as an exterior around spherical gold nanoparticles of various sizes to improve multivalency effects, measured antiviral effects of the antivirals on numerous viruses in vitro, and investigated the method of interaction of the leads with SARS-CoV-2 and lentiviral particles.

13 May 2022