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Using 'Trojan horse' strategy to kill deadly antibiotic-resistant pathogens

Pseudomonas aeruginosa is a dangerous bacterium that causes infections in hospital settings and in people with weakened immune systems.

24 Sep 2019

Researchers make breakthrough in understanding enzymes that assemble the antibiotic enacyloxin

One of the WHO's three critical priority pathogens, Acinetobacter baumannii, for which new antibiotics are urgently needed is one step closer to being tackled, as researchers from the Department of Chemistry - University of Warwick have made a breakthrough in understanding the enzymes that assemble the antibiotic enacyloxin.

24 Sep 2019

Cheaper drug equally effective in preserving cardiovascular function in boys with DMD

A new clinical trial conducted at The Ohio State University Wexner Medical Center found a cost-effective generic medication works just as well as a more expensive drug in preserving cardiovascular function in boys with Duchenne muscular dystrophy (DMD).

24 Sep 2019

Delivery of drugs within the brain can be improved by utilizing LAT1

According to a new study carried out at the University of Eastern Finland, the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain.

24 Sep 2019

Research: Protein complex represents a new metabolic target for liver cancer

Disrupting a metabolic pathway in the liver in a way that creates a more "cancer-like" metabolism actually reduces tumor formation in a mouse model of liver cancer.

24 Sep 2019

Onion and garlic may reduce risk of breast cancer

Onion and garlic are staple spices for many cuisines across the globe. There are numerous recipes requiring these two elements, and they may now be key ingredients in cutting the risk of breast cancer.

24 Sep 2019

Dogs can suffer from same autoimmune encephalitis as humans, research reveals

Researchers from North Carolina State University have found that dogs can suffer from the same type of autoimmune encephalitis that people do. The finding could lead to better screening methods for diagnosis and possibly more effective treatments for canine encephalitis.

24 Sep 2019

Newly synthesized anticancer compound can block cancer signaling mechanism

Of the various different functions that proteins perform in a cell, a crucial one is the recognition and transmission of certain "signals," collectively referred to as signal transduction.

24 Sep 2019

New drug delivery system could be a boon for those on a multi-drug regimen

Researchers from the University of North Carolina at Chapel Hill have developed a unique new multi-drug delivery system that could p-rove to be useful for persons who need to take several drugs in a day as part of a regimen.

23 Sep 2019

Advancing towards 100% effective herpes vaccine

Genital herpes, caused by the herpes simplex virus 2 (HSV-2) is a very common sexually transmitted infection (STI). It affects 14% of Americans aged 15-49 years. There is no herpes vaccine at present. Many failed attempts at vaccine production have centered around HSV proteins.

23 Sep 2019

New test to establish integrity of biosamples used in medical research

Effective diagnosis and treatment of disease draws on painstaking research, which often relies on biological samples.

23 Sep 2019

Scientists develop method to reactivate tumor suppressor genes 'silenced' by cancer

Scientists at UCL have developed a method to reactivate 'tumor suppressor' genes, which are switched off by cancer cells - a finding which could lead to new targeted biotherapies for cancer.

23 Sep 2019

New AGA guideline on evaluation of chronic diarrhea released

Diagnosing patients with chronic watery diarrhea can be difficult for health care providers, since several causes with specific therapies, such as inflammatory bowel disease (IBD), microscopic colitis and chronic infection, need to be ruled out.

23 Sep 2019

Researchers uncover fundamental difference in how DNA is held together

Researchers have made a fundamental discovery about the structure of DNA; the structure is held together by water, not hydrogen alone.

23 Sep 2019

Version of an antibiotic drug extends survival in mice with lethal pediatric brain tumors

Versions of an antibiotic drug called DON first isolated from soil bacteria more than 60 years ago have shown promising signs of extending survival in mice models of especially lethal pediatric brain tumors marked by the high expression of a cancer-causing gene known as the MYC oncogene, according to results of two studies from researchers at the Johns Hopkins Kimmel Cancer Center.

23 Sep 2019

Researchers use high-throughput mutagenesis approach to study ALS

Amyotrophic lateral sclerosis is a devastating and incurable nervous system disease that affects nerve cells in the brain and spinal cord, causing loss of muscle control and normally death within a few years of diagnosis.

23 Sep 2019

New study identifies potential enzyme target for diabetic retinopathy

A new study shows that diabetic retinopathy (DR), or retinal disease caused by the high blood glucose levels in diabetes mellitus, is due to the death of retinal cells because of the high levels of a pro-enzyme called lysyl oxidase propeptide (LOX-PP). This could help researchers develop specific treatments by targeting this molecule.

22 Sep 2019

RNA hitches lysosome rides to make proteins far away from the nucleus

Proteins inside a cell are often made at the site where they are used, rather than being shipped long distances. This is so with nerve cells which have long cell extensions in the form of axons and dendrites, up to four feet long in some case

22 Sep 2019

UTHealth's innovative cancer-fighting projects receive $11 million CPRIT funding

Five innovative cancer-fighting projects at The University of Texas Health Science Center at Houston received just over $11 million during the latest round of grants awarded by the Cancer Prevention and Research Institute of Texas

21 Sep 2019

Leukemia drug appears to be effective in treating deadly pediatric brain tumor

A drug used to treat chronic myeloid leukemia appears to be more effective at stopping a type of medulloblastoma in mouse models than existing treatments for the deadly pediatric brain tumor, reports a multi-institutional team led by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego.

21 Sep 2019