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Drug used to treat intestinal worms could protect people from periodontitis, says study

A drug currently used to treat intestinal worms could protect people from periodontitis, an advanced gum disease, which untreated can erode the structures-including bone-that hold the teeth in the jaw. The research was published ahead of print in Antimicrobial Agents and Chemotherapy.

11 Nov 2013

Early-life stress suspected to contribute to development of chronic pain in adulthood

Childhood neglect and abuse, whether physical or psychological, confers a lifetime vulnerability to stress, anxiety, and mood problems. Such early-life stress is also suspected to contribute to the development of chronic pain in adulthood.

6 Nov 2013

Scientists investigate combined action of two different compounds against CML

Currently no treatment option is available for five percent of patients suffering from chronic myelogenous leukemia, since they have developed resistance to conventional medications. Prof. Stephan Grzesiek's group at the Biozentrum of the University of Basel, in collaboration with Dr. Wolfgang Jahnke and colleagues from Novartis, has investigated the combined action of two different compounds against this form of leukemia.

6 Nov 2013

Prana's PBT2 effective in reversing memory, learning losses associated with aging process

Prana Biotechnology, a leading global developer of first-in-class treatments for neurodegenerative disease, has today announced the publication of an article in the peer reviewed Aging Cell showing the effects of PBT2 on neurogenesis and in reversing the memory and learning losses associated with the aging process, in normal (ie non transgenic) old mice.

31 Oct 2013

Researchers overcome obstacle to using viruses to deliver therapeutic genes

Scientists in The Research Institute at Nationwide Children's Hospital have found a way to overcome one of the biggest obstacles to using viruses to deliver therapeutic genes: how to keep the immune system from neutralizing the virus before it can deliver its genetic payload. In a study published recently in Molecular Therapy, researchers found that giving subjects a treatment to temporarily rid the body of antibodies provides the virus safe passage to targeted cells, allowing it to release a corrective or replacement gene to treat disease.

30 Oct 2013

Cdk5 protein may play crucial role in deadly form of thyroid cancer

A specific protein once thought to exist only in the brain may play a crucial role in a deadly form of thyroid cancer, as well as other cancers, and provide a fresh target for researchers seeking ways to stop its progression, UT Southwestern Medical Center researchers report today in Cancer Cell.

15 Oct 2013

New less invasive surgical method paves way for development of efficient anti-obesity therapies

Bariatric surgeries, such as a gastric bypass, are currently the most effective anti-obesity therapies. They also lead to a reduced insulin resistance. However, the pitfall of these surgical interventions is that they are highly invasive and often permanent procedures.

11 Oct 2013

Compugen drug candidate prevents autoimmune type I diabetes in animal model

Compugen Ltd., announced today that CGEN-15001, an Fc fusion protein drug candidate derived from a novel immune checkpoint protein discovered by Compugen, has been shown to be highly efficient in preventing the development of disease in a well-accepted animal model of autoimmune type I diabetes, known also as juvenile diabetes.

9 Oct 2013

New combinations of postoperative pain treatment decreased both pain and use of pain relievers

New combinations of postoperative pain treatment decreased both pain and the use of narcotic pain relievers according to two studies presented this week at the 2013 Clinical Congress of the American College of Surgeons.

9 Oct 2013

GABA inverse agonist restores learning, memory performances in cognitively-impaired DS mice

A selective GABA inverse agonist has restored cognitive function in a mouse model of Down's syndrome (DS) and has the potential to benefit humans, French researchers have revealed.

8 Oct 2013

$Binge drinking can impair healing process following bone fracture$

Binge drinking can impair healing process following bone fracture

Physicians have long observed that binge drinking can significantly impair the healing process following a bone fracture.

7 Oct 2013

Dying heart cells are kept alive with spikes of oxygen

In a study published in published in EMBO Molecular Medicine, a Dartmouth researcher found that dying heart cells are kept alive with spikes of oxygen.

5 Oct 2013

Study shows direct causative link between obesity and risk of pancreatic cancer in mice

Researchers at UCLA's Jonsson Comprehensive Cancer Center (JCCC) have found that mice made obese by being given high-calorie, high-fat diets (HFCD) developed abnormally high numbers of lesions known as pancreatic intraepithelial neoplasias (PanINs), which are known to be precursors to pancreas cancer.

1 Oct 2013

Short-term hearing loss during childhood may lead to persistent hearing deficits

Short-term hearing loss during childhood may lead to persistent hearing deficits, long after basic auditory sensitivity has returned to normal. The processing of sound in the brain is shaped by early experience.

1 Oct 2013

Biochemists discover promising vitamin D-based treatment that halts or reverse MS

A diagnosis of multiple sclerosis (MS) is a hard lot. Patients typically get the diagnosis around age 30 after experiencing a series of neurological problems such as blurry vision, wobbly gait or a numb foot. From there, this neurodegenerative disease follows an unforgiving course.

1 Oct 2013

Biochemists discover promising vitamin D-based treatment that can halt MS

A diagnosis of multiple sclerosis is a hard lot. Patients typically get the diagnosis around age 30 after experiencing a series of neurological problems such as blurry vision, wobbly gait or a numb foot. From there, this neurodegenerative disease follows an unforgiving course.

29 Sep 2013

Ablynx Nets Another $33.7M From Merck Serono As Partnership Expands

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27 Sep 2013

Study: Antidepressant drugs prove to be effective against SCLC patients

A bioinformatics approach to repurposing drugs resulted in identification of a class of antidepressants as a potential new treatment for small-cell lung cancer (SCLC), according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

27 Sep 2013

New animal model may help study immune responses to H. pylori infection

Researchers at the Virginia Bioinformatics Institute at Virginia Tech have developed a new large animal model to study how the immune system interacts with the stomach bacterium Helicobacter pylori, the leading cause of peptic ulcer disease.

26 Sep 2013

Pancreatic Cancer Imaging Agent Earns Mabvax $1.75M SBIR Award

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24 Sep 2013

Animal Model News and Research

Drug used to treat intestinal worms could protect people from periodontitis, says study

Early-life stress suspected to contribute to development of chronic pain in adulthood

Scientists investigate combined action of two different compounds against CML

Prana's PBT2 effective in reversing memory, learning losses associated with aging process

Researchers overcome obstacle to using viruses to deliver therapeutic genes

Cdk5 protein may play crucial role in deadly form of thyroid cancer

New less invasive surgical method paves way for development of efficient anti-obesity therapies

Compugen drug candidate prevents autoimmune type I diabetes in animal model

New combinations of postoperative pain treatment decreased both pain and use of pain relievers

GABA inverse agonist restores learning, memory performances in cognitively-impaired DS mice

Binge drinking can impair healing process following bone fracture

Dying heart cells are kept alive with spikes of oxygen

Study shows direct causative link between obesity and risk of pancreatic cancer in mice

Short-term hearing loss during childhood may lead to persistent hearing deficits

Biochemists discover promising vitamin D-based treatment that halts or reverse MS

Biochemists discover promising vitamin D-based treatment that can halt MS

Ablynx Nets Another $33.7M From Merck Serono As Partnership Expands

Study: Antidepressant drugs prove to be effective against SCLC patients

New animal model may help study immune responses to H. pylori infection

Pancreatic Cancer Imaging Agent Earns Mabvax $1.75M SBIR Award

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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