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UH and CWRU research teams win Collaborative Science Pilot Awards

Three University Hospitals (UH) and Case Western Reserve University School of Medicine research teams recently received Collaborative Science Pilot Awards. The teams each received $50,000, funded by both institutions.

28 Jun 2023

Single-cell transcriptomic analysis reveals specific cellular signatures for kidney transplant rejection

Imagine a day when a urine test could inform a doctor precisely why a kidney transplant patient was experiencing organ rejection and suggest the best medication for specifically addressing the problem.

28 Jun 2023

Novel computational tool helps analyze complex genetic regions

GeneDx (Nasdaq: WGS), a leader in delivering improved health outcomes through genomic and clinical insights, today published a paper in Nature Methods, titled "Multiscale analysis of pangenomes enables improved representation of genomic diversity for repetitive and clinically relevant genes," in which researchers developed a new computational tool, the PanGenome Research-Tool Kit (PGR-TK), for scalable analysis of clinically relevant genes that were previously too complex to analyze.

27 Jun 2023

New kidney cancer model highlights molecular targets and genomic events that drive metastasis

Researchers at The University of Texas MD Anderson Cancer have engineered a new model of aggressive renal cell carcinoma (RCC), highlighting molecular targets and genomic events that trigger chromosomal instability and drive metastatic progression.

26 Jun 2023

New computational technique shows promise for identifying different subtypes of Alzheimer's disease

A new computational technique that combines genomic and tau PET imaging data promises a more personalized approach for subtyping Alzheimer's disease.

26 Jun 2023

New hope for cystic fibrosis patients as groundbreaking treatment enters clinical trial

Clinical testing is underway for a potentially groundbreaking new treatment for cystic fibrosis. Pioneered by scientists at Carle Illinois College of Medicine at the University of Illinois Urbana-Champaign and the Carver College of Medicine at the University of Iowa in partnership with the spin-out biotechnology company, cystetic Medicines, this promising inhalable molecular prosthetic is intended to improve lung function in people with CF who cannot benefit from current therapies.

26 Jun 2023

Unveiling the link: gut microbiome, diet, and SARS-CoV-2 infections

Researchers determined the association between the gut microbiome and diet with severe acute respiratory syndrome coronavirus 2.

26 Jun 2023

Adopting a 30th birthday genetic profile test could save lives and NHS costs

A new study published in the US medical journal ‘The Annals of Internal Medicine’ makes a very strong case for universal genetic testing at the age of 30.

24 Jun 2023

BU study reveals crucial signaling pathway that drives head and neck cancers

Despite advances in defining the genomic characteristics of head and neck cancers, these malignancies continue to rank among the deadliest cancers with few targeted therapies available.

23 Jun 2023

Pangolin study uncovers novel strains of coronaviruses and raises concerns about origin

Researchers identify novel HKU4-related coronavirus in a pangolin single-cell sequencing dataset.

22 Jun 2023

First successful Phase 2 trial uses cutting-edge RNA CAR-T therapy to treat autoimmunity

Cartesian Therapeutics, a clinical-stage biotechnology company pioneering cell therapies for autoimmune diseases, announced today the publication of a landmark paper in The Lancet Neurology.

22 Jun 2023

Circulating cell-free mitochondrial DNA could be useful biomarkers for aging and inflammation

In an eight-year study of more than 600 community-dwelling older adults, Johns Hopkins Medicine researchers say they have further linked levels of cell-free DNA (DNA fragments resulting from cell death) circulating in the blood to chronic inflammation and frailty.

21 Jun 2023

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

Researchers performed a protein diffusion network analysis using tissue-specific GRNs to identify predispositions to COVID-19.

21 Jun 2023

Researchers identify Paenibacillus bacteria as responsible for postinfectious hydrocephalus in Uganda

In 2007, Yale pediatric neurosurgeon Steven Schiff, MD, visited his friend, Benjamin Warf, MD, at the CURE Children's Hospital of Uganda.

20 Jun 2023

Phase I clinical study of TCR NK cell therapy for sarcoma expected to commence later this year

The University of Texas MD Anderson Cancer Center and Replay today announced that the Food & Drug Administration (FDA) has issued a 'safe to proceed' for the Investigational New Drug (IND) application for NY-ESO-1 TCR/IL-15 NK, an engineered T cell receptor natural killer (TCR NK) cell therapy for advanced synovial sarcoma and myxoid/round cell liposarcoma.

20 Jun 2023

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Researchers evaluated the function of the zinc finger transcription factor ROB1 and its two phenotypically distinct alleles in the pathogenesis of Candida albicans infections.

20 Jun 2023

Urban jungle: How city living may impact mental health

Researchers explore the effects of the urban environment on adult mental health.

19 Jun 2023

New data demonstrates severe AMR among non-typhoidal Salmonella isolated from food in China

Announcing a new article publication for Zoonoses journal. Non-typhoidal Salmonella (NTS) is a major cause of human salmonellosis globally. Food animals are major NTS reservoirs.

19 Jun 2023

$Yourgene Health presents data demonstrating successful fetal fraction enrichment in NIPT workflows following prolonged blood storage in EDTA tubes$

Yourgene Health presents data demonstrating successful fetal fraction enrichment in NIPT workflows following prolonged blood storage in EDTA tubes

Yourgene Health plc, a leading international molecular diagnostics group, today presented data demonstrating that prolonged storage of blood in EDTA tubes is compatible with non-invasive prenatal testing (NIPT) when using size selection to enrich the fetal fraction.

From Yourgene Health 19 Jun 2023

PacBio collaborates with Radboudumc to explore genetic causes of rare and genetic diseases

PacBio, a leading developer of high-quality, highly accurate sequencing solutions today announced a clinical research study with Radboud University Medical Center (Radboudumc) to explore genetic causes of rare and genetic diseases.

19 Jun 2023

Genomic News and Research

UH and CWRU research teams win Collaborative Science Pilot Awards

Single-cell transcriptomic analysis reveals specific cellular signatures for kidney transplant rejection

Novel computational tool helps analyze complex genetic regions

New kidney cancer model highlights molecular targets and genomic events that drive metastasis

New computational technique shows promise for identifying different subtypes of Alzheimer's disease

New hope for cystic fibrosis patients as groundbreaking treatment enters clinical trial

Unveiling the link: gut microbiome, diet, and SARS-CoV-2 infections

Adopting a 30th birthday genetic profile test could save lives and NHS costs

BU study reveals crucial signaling pathway that drives head and neck cancers

Pangolin study uncovers novel strains of coronaviruses and raises concerns about origin

First successful Phase 2 trial uses cutting-edge RNA CAR-T therapy to treat autoimmunity

Circulating cell-free mitochondrial DNA could be useful biomarkers for aging and inflammation

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

Researchers identify Paenibacillus bacteria as responsible for postinfectious hydrocephalus in Uganda

Phase I clinical study of TCR NK cell therapy for sarcoma expected to commence later this year

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Urban jungle: How city living may impact mental health

New data demonstrates severe AMR among non-typhoidal Salmonella isolated from food in China

Yourgene Health presents data demonstrating successful fetal fraction enrichment in NIPT workflows following prolonged blood storage in EDTA tubes

PacBio collaborates with Radboudumc to explore genetic causes of rare and genetic diseases

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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