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Pork consumption is not likely to cause COVID-19 infection

According to the current state of knowledge, there are no cases that have shown evidence of humans being infected with the novel coronavirus via the consumption of contaminated food.

20 Nov 2020

New understanding of glycan signatures of the SARS-COV-2 S1 spike protein

A team of scientists from the University of Oxford, UK, has revealed that site-specific glycosylation differs between spike proteins derived from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a viral vector-based vaccine candidate.

18 Nov 2020

Researchers use proteogenomics to better understand the biological complexity of breast cancer

Researchers at Baylor College of Medicine, the Broad Institute of MIT and Harvard and other institutions have applied powerful proteogenomics approaches to better understand the biological complexity of breast cancer.

18 Nov 2020

Affinity-Bead Assisted Mass Spectrometry for Proteomics

In this interview, Ghaith Hamza from AstraZeneca talks to News-Medical Life Sciences about the basic principles of Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS) and how Affi-BAMS can help target specific proteins for proteomic applications.

From Bruker Daltonics 16 Nov 2020

Antimalarials could disrupt SARS-CoV-2’s Nsp1 translation termination

A research team from the Engelhardt Institute of Molecular Biology in Russia have shown that Nsp1 – a non-structured protein present in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen – stimulates translation termination in the stop codon recognition stage. Studying and developing drugs that compete with Nsp1 for binding with the termination complex could therefore be a potential strategy for fighting against coronavirus disease 2019 (COVID-19).

15 Nov 2020

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

The hunt for antivirals has reached an unprecedented pace in light of the coronavirus 2019 (COVID-19) pandemic. The causal agent for this disease – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – has already infected over 52 million people worldwide, and has subsequently claimed over 1.3 million lives. However, among the innumerable promising drug candidates that help battle the virus and mitigate its damage, none have yet made it to the clinic.

12 Nov 2020

Human coronaviruses cause processing body loss

Researchers continue to expand their knowledge of coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen. Now, a new study published on the preprint server bioRxiv in November 2020 describes a vital mechanism whereby the novel SARS-CoV-2 pathogen can restrict the human host response. In doing so, the study explores how this novel feature of SARS-CoV-2 works and how it results in a reshaping of the human host's immune response.

11 Nov 2020

Semi-automated approach accelerates artificial organoid growth and selection

The method currently used to produce stem cell-derived tissues has a very limited throughput. By semi-automating tissue differentiation, researchers from MIPT and Harvard have made the process nearly four times faster, without compromising on quality.

10 Nov 2020

Repairing brain damage caused by MS

Neurological symptoms as a result of Multiple Sclerosis (MS), such as loss of cognitive or motor function, lead to a great many problems for over 2.5 million people worldwide.

10 Nov 2020

PhoreMost and Oxford Biomedica collaborate to develop next-generation CAR-T cell therapies

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to developing drugs against intractable disease targets, and Oxford Biomedica plc, a leading gene and cell therapy group, today announced that they have entered into a discovery collaboration to develop next-generation CAR-T cell therapies.

From PhoreMost 10 Nov 2020

New machine learning method can decode brain signal patterns for specific behaviors

At any given moment in time, our brain is involved in various activities. For example, when typing on a keyboard, our brain not only dictates our finger movements but also how thirsty we feel at that time.

10 Nov 2020

Translational study within SARS-CoV-2 infected cells opens up new therapeutic avenues

A recent study published on the preprint server bioRxiv in October 2020 shows what the protein translation process looks like in specific terms. In doing so, the study has provided new insights that might prove helpful in developing new therapies for COVID-19 patients.

9 Nov 2020

RNA-binding proteins may suppress antiviral defenses against SARS-CoV-2

Conducted by researchers in South Korea at the Institute for Basic Science and the International Vaccine Institute, a new study published on the preprint server bioRxiv in November 2020 describes the many host proteins that bind with the ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and regulate the replication of the virus.

4 Nov 2020

BfR-Corona-Monitor: Many respondents have become more cautious about coronavirus

Starting this week, the new regulations for the containment of the coronavirus adopted by the Federal Government and the Länder will come into force throughout Germany.

3 Nov 2020

Hospitalized? You can still vote in most parts of the country

Johnathon Talamantes, of South-Central Los Angeles, broke his hip in a car accident on Oct. 22 and underwent surgery five days later at a public hospital near downtown.

2 Nov 2020

Research projects receive BTCA grants to develop novel drugs for various diseases

Five research projects with exceptional promise to deliver new life-changing and health-altering therapies have received the inaugural Blavatnik Therapeutics Challenge Awards (BTCA) at Harvard Medical School.

30 Oct 2020

New machine learning-based approach helps detect atrial fibrillation drivers

Researchers from Skoltech and their US colleagues have designed a new machine learning-based approach for detecting atrial fibrillation drivers, small patches of the heart muscle that are hypothesized to cause this most common type of cardiac arrhythmia.

29 Oct 2020

New portable arm rehabilitation device launched to help patients perform robot-aided therapy at home

A new portable arm rehabilitation robot will help patients to carry out robot-aided therapy at home, allowing them to perform intensive exercises without visiting hospitals or clinics, which can possibly reduce the risk of exposure to infectious diseases such as COVID-19.

28 Oct 2020

Structure and mechanisms of ribosomal frameshifting during SARS-CoV-2 translation

The structure of a 3’ stimulatory pseudoknot in the viral genome or by itself has been proposed recently. Researchers report the structure and mechanisms of mammalian ribosomes during translation of the -1 frameshifting of the SARS-CoV-2 viral genome in a new study published on the preprint server bioRxiv.

28 Oct 2020

Cleveland Clinic-led study identifies features associated with pathogenic and benign variants

An international team of researchers led by Cleveland Clinic's Lerner Research Institute has performed for the first time a wide-scale characterization of missense variants from 1,330 disease-associated genes.

27 Oct 2020

Translation News and Research

Pork consumption is not likely to cause COVID-19 infection

New understanding of glycan signatures of the SARS-COV-2 S1 spike protein

Researchers use proteogenomics to better understand the biological complexity of breast cancer

Affinity-Bead Assisted Mass Spectrometry for Proteomics

Antimalarials could disrupt SARS-CoV-2’s Nsp1 translation termination

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

Human coronaviruses cause processing body loss

Semi-automated approach accelerates artificial organoid growth and selection

Repairing brain damage caused by MS

PhoreMost and Oxford Biomedica collaborate to develop next-generation CAR-T cell therapies

New machine learning method can decode brain signal patterns for specific behaviors

Translational study within SARS-CoV-2 infected cells opens up new therapeutic avenues

RNA-binding proteins may suppress antiviral defenses against SARS-CoV-2

BfR-Corona-Monitor: Many respondents have become more cautious about coronavirus

Hospitalized? You can still vote in most parts of the country

Research projects receive BTCA grants to develop novel drugs for various diseases

New machine learning-based approach helps detect atrial fibrillation drivers

New portable arm rehabilitation device launched to help patients perform robot-aided therapy at home

Structure and mechanisms of ribosomal frameshifting during SARS-CoV-2 translation

Cleveland Clinic-led study identifies features associated with pathogenic and benign variants

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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