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Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Lonza is a large, multinational corporation serving the entire pharmaceutical product development and manufacturing pipeline, from non-clinical research products to final dosage and delivery solutions.

From Lonza 26 Mar 2020

Northwestern researcher receives NSF RAPID grant to develop self-sanitizing face mask

A Northwestern University researcher has received funding to develop a new self-sanitizing medical face mask that deactivates viruses on contact.

24 Mar 2020

Cleaning for coronavirus

As the novel coronavirus diseases (COVID-19) spreads to over 169 nations and territories across the globe, grinding to a halt nations and their healthcare systems, more and more countries are resorting to ‘lockdowns’ to prevent human to human transmission of the virus.

24 Mar 2020

Penn State engineers model genetic mutations causing drug resistance

Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and "second generation" approaches are needed.

24 Mar 2020

Using 'young NK cells' could improve the effectiveness of immunotherapy for cancer patients

Immunotherapy that involves treating cancer with the body's own immune cells, or those of a matched donor, shows promise in clinical trials for some patients, but not all.

22 Mar 2020

UC San Diego partners with five leading diagnostics manufacturers to ramp up testing for COVID-19

Partnering with five leading in vitro diagnostics manufacturers, an interdisciplinary team of scientists and physicians at UC San Diego Health and University of California San Diego School of Medicine today announced that the UC San Diego Center for Advanced Laboratory Medicine is significantly ramping up testing for COVID-19, projecting a capacity to complete 1,000 to 1,500 tests per day within two to three weeks.

22 Mar 2020

Lab-on-chip device to monitor how extracellular matrix responds to disease

Similarly to how a picked lock gives away that someone has broken into a building, the stiffening of a structure surrounding cells in the human body can indicate that cancer is invading other tissue.

21 Mar 2020

World’s fastest supercomputer identifies chemicals with potential to stop COVID-19

What makes the coronavirus disease (COVID-19) global pandemic different from the Spanish flu in 1918? In 1918, transportation, technology, and science were in their infancy, with the medical field not capable of fighting outbreaks. Technology has come a long way, within days, scientists have already identified the type of virus spreading in China, and three months after, vaccine trials have started.

20 Mar 2020

Organ-Chips provide human-relevant insights into diseases and toxicity mechanisms

Organs-on-Chips technology has entered the mainstream and has reached 150 installations for use by researchers across many industries, including 10 of the top 25 biopharmaceutical companies, as well as leading international academic research centers and U.S. government laboratories, including the U.S. FDA through a collaborative agreement and the U.S. Army.

20 Mar 2020

Substances linked to bladder cancer found in the urine of e-cigarette users

An analysis of evidence from multiple scientific studies found six substances that have a strong link to bladder cancer in the urine of people who had used electronic cigarettes and sometimes other tobacco products, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and NYU Langone Health reported.

19 Mar 2020

UCLA researcher awarded NIH grant to study pain-relieving effects of cannabis chemicals

Ziva Cooper, research director of the UCLA Cannabis Research Initiative, has been awarded a $3.9 million grant from the National Center for Complementary and Integrative Health at the NIH to study whether cannabis chemicals called terpenes can reduce the amount of opioid medication a person needs to reduce pain.

18 Mar 2020

Chronic microfiber exposure causes aneurysms, cellular changes in fish

Chronic exposure to microplastic fibers causes aneurysms, erosion of surface layers and other serious damage to fish gills, and increases egg production in female fish, a sign that chemicals in the fibers may be acting as endocrine disruptors, a new study by U.S. and Chinese scientists finds.

16 Mar 2020

Eating fish 1-3 times a week in pregnancy beneficial for the child

Pregnancy is a time when the mother’s diet becomes essential not only for reasons of proper nutrition but to avoid harm to or enhance the development of the child. Now a new study published in the journal JAMA Network Open in March 2020 shows that mothers who ate one to three servings of fish a week while they were pregnant gave birth to children with a better metabolic profile compared to those mothers who ate little or no fish at this time.

16 Mar 2020

Single-drug therapy can attack several cellular targets using different modes of action

Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action.

13 Mar 2020

What does COVID-19 do to the body?

The novel coronavirus SARS-CoV-2, also known as 2019-nCoV, is the virus that causes COVID-19, and that is spreading throughout the world is causing panic in almost all countries. With a death rate ranging from 1% to 2% in young patients but about 5%-8% in elderly and sick patients, it is capable of ravaging multiple organ systems in the human body.

12 Mar 2020

Vaping chemical can produce highly toxic gas when heated up, research reveals

A chemical found in some vaping products can produce a highly toxic gas when heated up, according to new research from RCSI University of Medicine and Health Sciences.

12 Mar 2020

A previously unknown mechanism could be new therapeutic target for cancer immunotherapy

Researchers at UC have discovered a previously unknown mechanism that could explain the reason behind decreased immune function in cancer patients and could be a new therapeutic target for immunotherapy for those with head and neck cancers.

10 Mar 2020

How effective is Gabapentin in alcohol use disorder?

A new study published in the journal JAMA Internal Medicine in March 2020 reports the striking efficacy of the drug gabapentin in helping people with alcohol use disorder (AUD) with their alcohol withdrawal symptoms.

9 Mar 2020

'Primitive' stem cells shown to replace and repair damaged blood vessels in the retina

Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes.

9 Mar 2020

Study looks at lung injury and vaping THC and vitamin E acetate

The US has witnessed a spate of patients presenting with acute lung injury associated with e-cigarettes or vaping product use. A new study published in the journal JAMA Internal Medicine shows the pattern of the outbreak in California where recreational cannabis use is legal and which has among the maximum cases of the strange illness.

8 Mar 2020

Chemicals News and Research

Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Northwestern researcher receives NSF RAPID grant to develop self-sanitizing face mask

Cleaning for coronavirus

Penn State engineers model genetic mutations causing drug resistance

Using 'young NK cells' could improve the effectiveness of immunotherapy for cancer patients

UC San Diego partners with five leading diagnostics manufacturers to ramp up testing for COVID-19

Lab-on-chip device to monitor how extracellular matrix responds to disease

World’s fastest supercomputer identifies chemicals with potential to stop COVID-19

Organ-Chips provide human-relevant insights into diseases and toxicity mechanisms

Substances linked to bladder cancer found in the urine of e-cigarette users

UCLA researcher awarded NIH grant to study pain-relieving effects of cannabis chemicals

Chronic microfiber exposure causes aneurysms, cellular changes in fish

Eating fish 1-3 times a week in pregnancy beneficial for the child

Single-drug therapy can attack several cellular targets using different modes of action

What does COVID-19 do to the body?

Vaping chemical can produce highly toxic gas when heated up, research reveals

A previously unknown mechanism could be new therapeutic target for cancer immunotherapy

How effective is Gabapentin in alcohol use disorder?

'Primitive' stem cells shown to replace and repair damaged blood vessels in the retina

Study looks at lung injury and vaping THC and vitamin E acetate

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