Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

Among premenopausal women with hormone receptor (HR)-positive, early-stage breast cancer enrolled in the SOFT trial, those with a high score on a genomic assay called Breast Cancer Index (BCI) had increased risk of distant recurrence, and those with low BCI benefited more from the addition of ovarian suppression therapy to endocrine therapy after 12 years of follow-up, according to data presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

New study details the neuronal response to excessive aged-related iron accumulation

Iron (Fe) accumulates in the brain cortex with aging. A plethora of studies indicate that progressive iron accumulation in the substantia nigra (SN) in the aged human brain is a major risk factor for Parkinson's disease (PD) and other neurodegenerative diseases, but not everyone.

6 Dec 2022

Consistent exercise linked to beneficial epigenetic changes, twin-study shows

Consistent exercise can change not just waistlines but the very molecules in the human body that influence how genes behave, a new study of twins indicates.

6 Dec 2022

Researchers discover new mechanism that enables cancer cells to move throughout the body

An international team of researchers has uncovered a new mechanism that enables cancer cells to move throughout the body, providing a potential new target to stop metastasis, which is responsible for 90 per cent of cancer deaths.

5 Dec 2022

Immunopeptidome characters of human CoV-OC43-infected cells

Researchers explored T-cell epitopes derived from human seasonal coronavirus OC43.

5 Dec 2022

Women with postpartum mood disorders may be suffering from irregular immune system responses

Women with prolonged mental health problems up to three years after childbirth may be suffering from irregular immune system responses, according to new research by Cedars-Sinai investigators.

2 Dec 2022

The effect of ubiquitination on SARS-CoV-2 infection and patient prognosis

A recent Clinical and Translational Medicine study utilized several published public datasets to evaluate the biological characteristics associated with the ubiquitination of patients infected with SARS-CoV-2.

2 Dec 2022

Collaborative work unravels hidden molecular secrets of age-related diseases

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, and the University of Copenhagen announced today the release of the first batch of results from the collaborative work directed to perform multi-omics-based analyses in the context of age-related diseases using an AI-driven target and drug discovery pipeline.

2 Dec 2022

Integrated approach addresses some of the biggest challenges in natural products drug discovery

Many successful drugs have their origins in natural sources such as plants, fungi, and bacteria, but screening natural products to identify potential drugs remains a difficult undertaking.

1 Dec 2022

Early life experiences can affect gene activity more than half a lifetime later

Early life experiences can impact the activity of our genes much later on and even affect longevity, finds a new study in fruit flies led by UCL researchers.

1 Dec 2022

Study suggests new strategies for making cartilage cells

As any weekend warrior understands, cartilage injuries to joints such as knees, shoulders, and hips can prove extremely painful and debilitating. In addition, conditions that cause cartilage degeneration, like arthritis and temporomandibular joint disorder (TMJ), affect 350 million people in the world and cost the US public health system more than $303 billion every year.

30 Nov 2022

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the worst in otherwise peaceable cells? Or is it a back-and-forth, a dialogue between the two?

30 Nov 2022

Researchers modulate the activity of potential therapeutic target for triple-negative breast cancer

Less than 20% of diagnosed breast cancers are designated "triple-negative," lacking three types of receptors often found in other breast cancer types.

30 Nov 2022

Research findings may offer a new potential therapeutic target for Alzheimer’s disease

A new study links a gene concentrated in the brain's cleanup cells, known as microglia, to the inflammation that has increasingly emerged as a key mechanism contributing to Alzheimer's disease.

30 Nov 2022

What genes are associated with asthma exacerbations?

In a new study, researchers reviewed the genomics, transcriptomics, and epigenetics of asthma exacerbations (AEs).

29 Nov 2022

New microfluidic Organ Chip platform replicates the human vaginal tissue microenvironment

The human microbiome has been a hot topic over the last decade, with research pointing to disrupted bacterial communities as culprits for a host of maladies including irritable bowel syndrome, eczema, and autoimmune diseases.

28 Nov 2022

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Mutations of BRCA1 and BRCA2 genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as ovarian, breast, pancreatic and prostate cancer.

28 Nov 2022

Common chemotherapy drug could carry toxic inheritance for future generations of cancer survivors

A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, Washington State University-led research indicates.

28 Nov 2022

Fossils of a tiny sea creature solve century-old debate over brain evolution in arthropods

Fossils of a tiny sea creature that died more than half a billion years ago may compel a science textbook rewrite of how brains evolved.

24 Nov 2022

Study provides a key link between the social environment and healthy brains

As people age, maintaining a positive and predictable social environment becomes more and more important. For instance, keeping close ties with friends and family has been identified as one of the key ingredients to healthy aging.

24 Nov 2022

Gene Expression News and Research

Further Reading

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

New study details the neuronal response to excessive aged-related iron accumulation

Consistent exercise linked to beneficial epigenetic changes, twin-study shows

Researchers discover new mechanism that enables cancer cells to move throughout the body

Immunopeptidome characters of human CoV-OC43-infected cells

Women with postpartum mood disorders may be suffering from irregular immune system responses

The effect of ubiquitination on SARS-CoV-2 infection and patient prognosis

Collaborative work unravels hidden molecular secrets of age-related diseases

Integrated approach addresses some of the biggest challenges in natural products drug discovery

Early life experiences can affect gene activity more than half a lifetime later

Study suggests new strategies for making cartilage cells

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

Researchers modulate the activity of potential therapeutic target for triple-negative breast cancer

Research findings may offer a new potential therapeutic target for Alzheimer’s disease

What genes are associated with asthma exacerbations?

New microfluidic Organ Chip platform replicates the human vaginal tissue microenvironment

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Common chemotherapy drug could carry toxic inheritance for future generations of cancer survivors

Fossils of a tiny sea creature solve century-old debate over brain evolution in arthropods

Study provides a key link between the social environment and healthy brains

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