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Mice study shows how COVID-19 damages organs other than the lungs

UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs.

8 Dec 2020

Antibody responses to SARS-CoV-2 virus disappear quickly during convalescence, indicates study

A new 5-month longitudinal analysis of 254 COVID-19 patients who displayed a wide range of disease severity - from asymptomatic to deadly illness - suggests that IgA and IgM antibodies to the SARS-CoV-2 virus disappear quickly during convalescence.

7 Dec 2020

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

The COVID-19 pandemic is showing a strong comeback after an initial reduction in the number of cases, following energetic public health interventions.

7 Dec 2020

STE90-C11, a SARS-CoV-2 neutralizing antibody, shows high inhibition of RBD-ACE2 binding

In a new study, researchers describe the identification of a neutralizing antibody that binds to the RBD at the same site as the human host cell receptor.

7 Dec 2020

Novel modular design approach to antibody nanocage generation

A new study shows the benefits of using computational design to create antibody nanocages that have the required orientation.

7 Dec 2020

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

A new study indicates that the topoisomerase 1 (Top1) is intimately related to the lethal inflammation associated with SARS-CoV-2 infection in a large proportion of cases.

7 Dec 2020

Low testosterone can increase risk of severe COVID-19 in males

Researchers from the USA and Saudi Arabia describe the direct correlation between testosterone levels, inflammatory cytokines, disease progression, and worse outcomes in male COVID-19 patients.

4 Dec 2020

Understanding why some people are more vulnerable to COVID-19

What makes the elderly and people with underlying conditions more vulnerable to COVID-19? According to a new study led by McGill University researchers, clues can be found in the proteins involved in initiating infection, as the virus binds to host cells of different animals.

3 Dec 2020

Can melatonin help prevent severe COVID-19?

A team of researchers at the University of Toronto in Canada has found that melatonin can be an adjuvant to augment the efficacy of anti-SARS-CoV-2 vaccines. They believe that the drug is a potential “silver bullet” to combat the COVID-19 pandemic.

3 Dec 2020

Designed proteins assemble antibodies into modular nanocages

With cues from nature, designing functional molecules enables scientists to nanoengineer and customize for specific uses.

3 Dec 2020

Nanoparticles with neutralizing antibodies can inactivate SARS-CoV-2

Using nanoparticles conjugated with SARS-CoV-2 neutralizing antibodies, researchers demonstrated that intense local heating could inactivate the virus.

3 Dec 2020

Long-range allosteric influences on SARS-COV-2-ACE2 stability and detachment

The COVID-19 pandemic is caused by SARS-CoV-2, a novel beta-coronavirus which has numerous spike proteins on its membrane.

3 Dec 2020

N-Glycosylation sites may contribute to spike-mediated invasion by SARS-CoV-2

The sugar residues decorating the spike (S) protein of SARS-CoV-2 are essential to the viral-receptor binding.

3 Dec 2020

COVID-19 mutation mapping identifies escape mutations against therapeutic antibodies

A new study maps all known mutations in the SARS-CoV-2 virus, showing how each contributes to escape from individual antibodies.

3 Dec 2020

SARS-CoV-2 enters the CNS via multiple routes and causes various neurological disorders

The COVID-19 pandemic has led to millions of deaths across the globe. The causative agent of this disease is the novel coronavirus, SARS-CoV-2.

3 Dec 2020

Pomegranate extract could inhibit the virus that causes COVID-19

Researchers have conducted a study demonstrating the potential antiviral effects of pomegranate extract against SAR-CoV-2.

3 Dec 2020

Novel “multitope” vaccine shows promise in the fight against COVID-19

Researchers have demonstrated the potential of a protein-peptide vaccine to protect against infection with SARS-CoV-2, the agent that causes COVID-19.

3 Dec 2020

Chronic kidney disease strongly associated with COVID-related hospitalization

An analysis of Geisinger's electronic health records has revealed chronic kidney disease to be the leading risk factor for hospitalization from COVID-19.

2 Dec 2020

New and sudden headaches may be a symptom of COVID-19

Researchers report a case of a young male patient who came in with a headache to an emergency room. He had increased intracranial pressure and tested positive for SARS-CoV-2, suggesting new headaches during the pandemic should not be ignored.

2 Dec 2020

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

A team of researchers at the University of Tokyo in Japan have detected a sarbecovirus, called Rc-o319, which is phylogenetically positioned in the same clade as SARS-CoV-2 in Rhinolophus cornutus bats in Japan.

2 Dec 2020

ACE2 News and Research

Mice study shows how COVID-19 damages organs other than the lungs

Antibody responses to SARS-CoV-2 virus disappear quickly during convalescence, indicates study

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

STE90-C11, a SARS-CoV-2 neutralizing antibody, shows high inhibition of RBD-ACE2 binding

Novel modular design approach to antibody nanocage generation

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

Low testosterone can increase risk of severe COVID-19 in males

Understanding why some people are more vulnerable to COVID-19

Can melatonin help prevent severe COVID-19?

Designed proteins assemble antibodies into modular nanocages

Nanoparticles with neutralizing antibodies can inactivate SARS-CoV-2

Long-range allosteric influences on SARS-COV-2-ACE2 stability and detachment

N-Glycosylation sites may contribute to spike-mediated invasion by SARS-CoV-2

COVID-19 mutation mapping identifies escape mutations against therapeutic antibodies

SARS-CoV-2 enters the CNS via multiple routes and causes various neurological disorders

Pomegranate extract could inhibit the virus that causes COVID-19

Novel “multitope” vaccine shows promise in the fight against COVID-19

Chronic kidney disease strongly associated with COVID-related hospitalization

New and sudden headaches may be a symptom of COVID-19

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

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