Pathogen News and Research

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Human coronaviruses need organic materials to transfer efficiently between surfaces

This study, published in the journal Viruses, indicated that human coronaviruses do not transfer effectively from contaminated hands to contact surfaces without the presence of any organic material.

21 Jul 2021

UTHSC announces an increase in research grant and contract awards for FY21

The University of Tennessee Health Science Center's Office of Research announced that annual research grant and contract awards for FY21, which ended June 30, total more than $121 million, a 20.6% increase from last year.

20 Jul 2021

Study: Second dose of COVID-19 vaccine induces a powerful boost to the immune system

The second dose of a COVID-19 vaccine induces a powerful boost to a part of the immune system that provides broad antiviral protection, according to a study led by investigators at the Stanford University School of Medicine.

19 Jul 2021

Study suggests children develop short-term humoral immunity following SARS-CoV-2 infection

A single-center, cross-sectional epidemiological survey conducted in Israel has recently pointed out that antibodies induced by natural SARS-CoV-2 infection in children start declining just after 4 months of acute infection. However, their seropositivity rates are not impacted by school reopening. The study has recently been published in the journal Acta Paediatrica.

19 Jul 2021

Plant-based vaccines for COVID-19 and other viruses

A review published in the journal Vaccines, explored the history and current status of plant-produced vaccine candidates against enveloped viruses, focusing on virus-like particles (VLPs), which mimic authentic viral structures without containing infectious genetic material.

19 Jul 2021

Researchers study the role of subnuclear NSrp70 in T cell-mediated adaptive immunity

T cells are components of the body’s immune system. The ability of T cells to recognize diverse pathogens and mount a defense against them stems from the way proteins are spliced during their development and maturation.

15 Jul 2021

Short chain fatty acids have potential therapeutic applications against COVID-19, study suggests

SARS-CoV-2, the virus responsible for the COVID-19 pandemic, is highly transmissible, with nasal passages being the target of original infection.

15 Jul 2021

Rapid COVID-19 antibody detection with time‐resolved fluorescence immunoassay

A new study published in the journal Biotechnology and Applied Biochemistry deals with the development of a time-resolved fluorescence immunoassay (TRFIA) for the detection of total COVID-19 antibodies in humans.

15 Jul 2021

Could corticosteroids increase mortality in COVID-19 patients without high oxygen supplementation?

A new paper focuses on the role of corticosteroids, in particular, as these were widely used among patients on intensive respiratory support (IRS).

14 Jul 2021

Research identifies key role of CXCL9 cytokine in age-related chronic inflammation

An inflammatory-aging clock called developed by Stanford University School of Medicine and the Buck Institute for Research on Aging can predict how strong your immune system will be in 10 years, when you'll become frail or whether you may develop cardiovascular diseases a few years down the road.

14 Jul 2021

Colonization by SARS-CoV-2 not synonymous with infection, screening study highlights

A new study released as a preprint on the medRxiv* server throws cold water on this notion, however, by demonstrating that in a set of asymptomatic cases, less than a tenth actually had evidence of SARS-CoV-2 infection. This finding has serious implications for the practices mentioned above, since they may be neither justifiable nor cost-effective as means to break the chain of viral transmission.

13 Jul 2021

“React and inject”: synthetic peptide-modified nanodiamonds as emergency pan-coronavirus vaccines

A recent study published in the MDPI journal, Pathogens, describes a coronavirus peptide vaccine antigen in the form of nanodiamond-based formulations, that demonstrated a robust and long-lasting immune response. The nanodiamonds proved to be a powerful and versatile platform for antigen conjugation. This could make it a safe and effective strategy for the production of off-the-shelf vaccines against multiple coronaviruses.

13 Jul 2021

Natural compound 'pheophorbide a' demonstrates robust antiviral activity against SARS-CoV-2 in vitro

A team of scientists from France has recently demonstrated photosensitive antiviral activity of the natural compound pheophorbide a (Pba) against a broad range of enveloped viruses, including coronaviruses.

12 Jul 2021

Scientists identify novel entry receptors for SARS-CoV-2

Scientists from the Northeastern University, China, and University of Michigan, USA, have recently identified five potential entry receptors for SARS-CoV-2. These receptors specifically express in SARS-CoV-2-infected cells and have a high binding affinity for the viral spike protein.

12 Jul 2021

mRNA-based COVID-19 vaccine CV07050101 demonstrates limited immunogenicity in non-human primates

Scientists from the US and Germany have recently evaluated the efficacy of an mRNA-based COVID-19 vaccine candidate, CV07050101, in inducing humoral and cellular immune responses in non-human primates. The study reveals that prime-boost immunization with the vaccine candidate induces only limited immunity against SARS-CoV-2.

12 Jul 2021

Composition and structure of nasopharyngeal microbiome relate to COVID-19 disease severity

Breathing treatments are provided to hospitalized COVID-19 patients. In this study, the researchers examined the community composition in relation to three attributes - COVID-19 status, breathing assistance, and antibiotic use. This study is published in the journal, Applied Microbiology.

12 Jul 2021

Immaturity of gut microbiota and epithelial barriers linked to neonatal meningitis

Meningitis is associated with high mortality and frequently causes severe sequelae. Newborn infants are particularly susceptible to this type of infection; they develop meningitis 30 times more often than the general population.

9 Jul 2021

Do lockdowns exert selection pressure on overdispersion of SARS-CoV-2 variants?

New research recently released on the medRxiv* preprint server describes a mathematical model that has been developed to evaluate competitions between variants that differ in their level of overdispersion (k) and their mean infectiousness.

8 Jul 2021

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

A new article has been published in Cellular and Molecular Lifesciences, which focuses on the connection between host factors and the worsening of the COVID-19. Further, the impact of the virus on the host’s microbiome and secondary infection has also been studied.

8 Jul 2021

Scientists study how our immune system responds to COVID-19 variants

Australian scientists researching how our immune system responds to COVID-19 have revealed that those infected by early variants in 2020 produced sustained antibodies, however, these antibodies are not as effective against contemporary variants of the virus.

8 Jul 2021

Pathogen News and Research

Human coronaviruses need organic materials to transfer efficiently between surfaces

UTHSC announces an increase in research grant and contract awards for FY21

Study: Second dose of COVID-19 vaccine induces a powerful boost to the immune system

Study suggests children develop short-term humoral immunity following SARS-CoV-2 infection

Plant-based vaccines for COVID-19 and other viruses

Researchers study the role of subnuclear NSrp70 in T cell-mediated adaptive immunity

Short chain fatty acids have potential therapeutic applications against COVID-19, study suggests

Rapid COVID-19 antibody detection with time‐resolved fluorescence immunoassay

Could corticosteroids increase mortality in COVID-19 patients without high oxygen supplementation?

Research identifies key role of CXCL9 cytokine in age-related chronic inflammation

Colonization by SARS-CoV-2 not synonymous with infection, screening study highlights

“React and inject”: synthetic peptide-modified nanodiamonds as emergency pan-coronavirus vaccines

Natural compound 'pheophorbide a' demonstrates robust antiviral activity against SARS-CoV-2 in vitro

Scientists identify novel entry receptors for SARS-CoV-2

mRNA-based COVID-19 vaccine CV07050101 demonstrates limited immunogenicity in non-human primates

Composition and structure of nasopharyngeal microbiome relate to COVID-19 disease severity

Immaturity of gut microbiota and epithelial barriers linked to neonatal meningitis

Do lockdowns exert selection pressure on overdispersion of SARS-CoV-2 variants?

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

Scientists study how our immune system responds to COVID-19 variants

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