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DNA enhancers switch on colorectal cancer genes to promote tumor growth, study finds

Genetic mutations can increase a person's cancer risk, but other gene "enhancer" elements may also be responsible for disease progression, according to new research out of Case Western Reserve University School of Medicine.

7 Mar 2017

Researchers identify mechanisms involved in acid pump

Researchers at Aarhus University, Denmark, have succeeded in identifying the mechanisms involved in what is known as the acid pump, which at the cellular level pumps acid into the stomach - in some cases leading to gastric ulcers and gastroesophageal reflux disease.

7 Mar 2017

Clinical study seeks to examine new combination therapy for treating AML patients

A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.

7 Mar 2017

Researchers reveal how overloading of protein transport mechanisms triggers cellular defects

Researchers at Okayama University report in Scientific Reports how the overloading of protein transport mechanisms affects cell functioning. Over-expression of different types of target proteins leads to cellular growth defects, and the mechanism for transporting proteins out of a cell nucleus has the lowest over-expression tolerance.

7 Mar 2017

New drug-like compound shows potential to treat symptoms of lupus

Lupus, a chronic autoimmune disease, has proved difficult to treat, but a new international study co-led by a Rush University Medical Center researcher suggests that a drug starting through the pipeline could ameliorate or even eliminate the symptoms in most sufferers.

7 Mar 2017

Researchers issue first predictive risk model of colon, rectal cancer based on data from Spanish population

Researchers of the Colorectal Cancer research group of Bellvitge Biomedical Research Institute, led by Dr. Víctor Moreno, and linked to the Catalan Institute of Oncology, the University of Barcelona and the Epidemiology and Public Health CIBER, have issued the first predictive risk model of colon and rectal cancer based on Spanish data that combines genetic and lifestyle information.

7 Mar 2017

Nanomaterial-based bone regeneration technology could help people suffering from severe injuries

Advanced materials are revolutionizing our daily lives — from clothing to clinics to … cattle? A nanomaterial-based bone regeneration technology developed at the University of Arkansas at Little Rock helped save a valuable animal's life. In the future, this technology could help people suffering from a variety of severe injuries and ailments.

7 Mar 2017

Researchers uncover new genetic clues linked to autoimmune kidney disease

Researchers have uncovered new genetic clues to understanding IgA nephropathy (IgAN), or Berger's disease, an autoimmune kidney disease and a common cause of kidney failure.

6 Mar 2017

Researchers identify 90 genes in fat that could play key roles in cardiometabolic diseases

A sweeping international effort is connecting the dots between genes in our fat cells and our risk for obesity and cardiometabolic diseases such as heart disease and type 2 diabetes.

6 Mar 2017

Study: Political leanings, weight influence people's opinions on obesity-related public policies

People's political leanings and their own weight shape opinions on obesity-related public policies, according to a new study by two University of Kansas researchers.

6 Mar 2017

Researchers identify gene variants that may predispose individuals to develop gallbladder cancer

By comparing the genetic code of gallbladder cancer patients with those of healthy volunteers at nearly 700,000 different locations in the genome, researchers say they have found several gene variants which may predispose individuals to develop the disease.

6 Mar 2017

Michigan Medicine opens first clinic in the United States that focuses on prostate cancer risk

It's well known that women with certain hereditary genetic mutations, particularly BRCA1 and BRCA2, have an increased risk of breast cancer. But in recent years, researchers have discovered a link between some of those same genetic mutations - along with a handful of others - and aggressive prostate cancer.

3 Mar 2017

New progeria-on-a-chip model provides better understanding of vascular disease and aging

Hutchinson-Gilford progeria syndrome is an extremely rare genetic condition that causes premature and accelerated aging.

3 Mar 2017

Sun protection can benefit both health and appearance

As the winter temperatures begin to thaw, many may be dreaming of a sun-drenched spring and summer, and some may be hoping to show off a tan. While these individuals may believe tanning makes them more beautiful, this habit can actually damage their skin in the long run.

3 Mar 2017

Doctoral student in biology investigating cause of hereditary neurodegenerative disease

Babita Adhikari Dhungel, doctoral student in biology from Nepal, is researching the cause of CLN8 disease, which is a form of neuronal ceroid lipofuscinoses.

3 Mar 2017

Study describes method to engineer brown adipose tissue from white fat-derived stem cells

Researchers have demonstrated the potential to engineer brown adipose tissue, which has therapeutic promise to treat metabolic diseases such as obesity and type 2 diabetes, from white adipose-derived stem cells.

3 Mar 2017

WHO releases first ever list of antibiotic-resistant 'priority pathogens'

The World Health Organization today published its first ever list of antibiotic-resistant “priority pathogens”—a catalogue of 12 families of bacteria that pose the greatest threat to human health.

3 Mar 2017

Researchers discover 'Developmental Split-Brain syndrome' caused by biallelic mutations in DCC gene

In a study published in Nature Genetics, Dr Saumya Jamuar, co-founder of Global Gene Corp and a visiting scientist at Harvard Medical School, under the supervision of Prof Christopher Walsh and A/Prof Timothy Yu of Harvard Medical School, reports on a new disease entity that they discovered in their quest to map novel human disorders related to brain development.

3 Mar 2017

Researchers develop smart genetic reference library for locating disease-causing mutations

Researchers at Hiroshima University have developed a smart genetic reference library for locating and weeding out disease-causing mutations in populations.

3 Mar 2017

Metabolic vulnerability in triple-negative breast cancer cells may help quell chemotherapy resistance

A team of researchers led by Alex Toker of the Ludwig Center at Harvard has discovered a metabolic weakness in triple-negative breast cancer cells that may be exploited to quell their resistance to chemotherapy.

2 Mar 2017

Genetic News and Research

DNA enhancers switch on colorectal cancer genes to promote tumor growth, study finds

Researchers identify mechanisms involved in acid pump

Clinical study seeks to examine new combination therapy for treating AML patients

Researchers reveal how overloading of protein transport mechanisms triggers cellular defects

New drug-like compound shows potential to treat symptoms of lupus

Researchers issue first predictive risk model of colon, rectal cancer based on data from Spanish population

Nanomaterial-based bone regeneration technology could help people suffering from severe injuries

Researchers uncover new genetic clues linked to autoimmune kidney disease

Researchers identify 90 genes in fat that could play key roles in cardiometabolic diseases

Study: Political leanings, weight influence people's opinions on obesity-related public policies

Researchers identify gene variants that may predispose individuals to develop gallbladder cancer

Michigan Medicine opens first clinic in the United States that focuses on prostate cancer risk

New progeria-on-a-chip model provides better understanding of vascular disease and aging

Sun protection can benefit both health and appearance

Doctoral student in biology investigating cause of hereditary neurodegenerative disease

Study describes method to engineer brown adipose tissue from white fat-derived stem cells

WHO releases first ever list of antibiotic-resistant 'priority pathogens'

Researchers discover 'Developmental Split-Brain syndrome' caused by biallelic mutations in DCC gene

Researchers develop smart genetic reference library for locating disease-causing mutations

Metabolic vulnerability in triple-negative breast cancer cells may help quell chemotherapy resistance

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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