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Innovative gene therapy allows complete remission of clinical signs of sickle cell disease

A team led by Pr. Marina Cavazzana conducted at Necker Children's Hospital, AP-HP and the Imagine Institute in October 2014 gene therapy in the context of a phase I clinical trial / II in a patient 13 years with severe sickle cell disease.

2 Mar 2017

Study provides insights into how cancer cells can evade FGFR inhibitors

A new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

2 Mar 2017

Study of U.S. Navy healthcare personnel finds higher PTSD risk among women than men

A study of U.S. Navy healthcare personnel has shown that when comparing the prevalence of post-traumatic stress disorder (PTSD) among women and men who had similar deployment experiences, and especially combat experience, the risk of PTSD was significantly higher among women.

2 Mar 2017

Advances in Optogenetics

Optogenetics is a way of introducing information into the brain using light, it targets specific cells or connections across the brain. It is fast, like brain signaling, and helps you communicate with neural circuitry in a language more similar to what is normally used within the brain.

From Pittcon 2 Mar 2017

Cholesterol-processing enzyme could be therapeutic target to stave off neurologic diseases

An enzyme that helps break down cholesterol may also be a therapeutic target to stave off neurologic diseases, including Alzheimer's and a rare genetic disorder, according to a new study published in the Journal of Biological Chemistry.

2 Mar 2017

Brains of adolescents with anorexia nervosa remain altered even after treatment, study finds

Even after weeks of treatment and considerable weight gain, the brains of adolescent patients with anorexia nervosa remain altered, putting them at risk for possible relapse, according to researchers at the University of Colorado Anschutz Medical Campus.

1 Mar 2017

Highly prevalent gene variants in African Americans contribute to kidney disease

African Americans have a heightened risk of developing chronic and end-stage kidney disease. This association has been attributed to two common genetic variants - named G1 and G2 -- in APOL1, a gene that codes for a human-specific protein.

1 Mar 2017

Study identifies potential therapeutic target for bone repair in adults with severe injury or disease

Irish scientists are developing an advanced technology to speed up bone repair in adults who have suffered severe fractures and bone degeneration.

1 Mar 2017

Duke researchers discover potential cause for ALS syndromes using mouse models

A team of researchers at Duke University Medical Center led by Dr. Paulo Ferreira and whose work was supported by the National Institutes of Health has found that derailing the transport of certain receptors that carry cargoes from and to the nucleus of motor neurons causes motor neuron disease in mice.

1 Mar 2017

Researchers develop improved method for using graphene-based transistors to detect harmful genes

Researchers in India and Japan have developed an improved method for using graphene-based transistors to detect disease-causing genes.

1 Mar 2017

Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Adolescent, early adult diet linked to chronic inflammation may increase premenopausal breast cancer risk

Women who consumed a diet as adolescents or young adults associated with chronic inflammation had a higher risk for premenopausal breast cancer compared with those whose adolescent and early adulthood diet was not associated with chronic inflammation.

1 Mar 2017

New report expresses ethical concerns about use of non-invasive prenatal testing

A new report on non-invasive prenatal testing by the UK's Nuffield Council on Bioethics expresses concerns about the way the test is being sold by private providers.

1 Mar 2017

Two migration proteins increase predictive ability of biomarker for pancreatic cancer

Adding two blood-borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

1 Mar 2017

Study: People with intermittent explosive disorder at greater risk for substance abuse

People with intermittent explosive disorder—a condition marked by frequent physical or verbal outbursts—are at five times greater risk for abusing substances such as alcohol, tobacco and marijuana than those who don't display frequent aggressive behavior, according to a new study by researchers from the University of Chicago.

1 Mar 2017

Mayo Clinic researchers identify new genetic risk factor for late-onset Alzheimer's in African-Americans

A Mayo Clinic research team has found a new gene mutation that may be a risk factor for late-onset Alzheimer's disease in African-Americans.

28 Feb 2017

Danish researchers get closer to finding treatment for malignant cerebral tumour in children

DIPG (Diffuse Intrinsic Pontine Glioma) is a rare malignant cerebral tumour in children. It has only a 1% 5-year survival rate, amongst other things because it is not possible to operate because the tumour is located in the brain stem.

28 Feb 2017

Walnut-enriched diet may improve sperm quality, animal research suggests

New animal research suggests eating a walnut-enriched diet may improve sperm quality by reducing lipid peroxidation, a process that can damage sperm cells.

28 Feb 2017

Biologists develop new way to inhibit cancer cell cleanup mechanism

The genomes of cancer cells--cells that do not obey signals to stop reproducing--are riddled with genetic mutations, causing them inadvertently to make many dysfunctional proteins.

28 Feb 2017

Study suggests new strategy for treating Alzheimer's disease

Alzheimer's disease (AD) is one of the most common form of dementia. In search for new drugs for AD, the research team, led by Professor Mi Hee Lim of Natural Science at UNIST has developed a metal-based substance that works like a pair of genetic scissors to cut out amyloid-β (Aβ), the hallmark protein of AD.

28 Feb 2017

Genetic News and Research

Innovative gene therapy allows complete remission of clinical signs of sickle cell disease

Study provides insights into how cancer cells can evade FGFR inhibitors

Study of U.S. Navy healthcare personnel finds higher PTSD risk among women than men

Advances in Optogenetics

Cholesterol-processing enzyme could be therapeutic target to stave off neurologic diseases

Brains of adolescents with anorexia nervosa remain altered even after treatment, study finds

Highly prevalent gene variants in African Americans contribute to kidney disease

Study identifies potential therapeutic target for bone repair in adults with severe injury or disease

Duke researchers discover potential cause for ALS syndromes using mouse models

Researchers develop improved method for using graphene-based transistors to detect harmful genes

Using Spherical Nucleic Acids to Track and Treat Disease

Adolescent, early adult diet linked to chronic inflammation may increase premenopausal breast cancer risk

New report expresses ethical concerns about use of non-invasive prenatal testing

Two migration proteins increase predictive ability of biomarker for pancreatic cancer

Study: People with intermittent explosive disorder at greater risk for substance abuse

Mayo Clinic researchers identify new genetic risk factor for late-onset Alzheimer's in African-Americans

Danish researchers get closer to finding treatment for malignant cerebral tumour in children

Walnut-enriched diet may improve sperm quality, animal research suggests

Biologists develop new way to inhibit cancer cell cleanup mechanism

Study suggests new strategy for treating Alzheimer's disease

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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