Clinical Trial News and Research

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Medarex announces allowance of IND application for antibody-drug conjugate, MDX-1203

Medarex, Inc. has announced the allowance of an investigational new drug (IND) application filed with the U.S. Food & Drug Administration (FDA) for MDX-1203, the Company's first Antibody-Drug Conjugate (ADC) candidate generated from its proprietary technology.

29 Jan 2009

Study compares exercise regimens for obese older adults

Sedentary, obese older adults appear to improve their functional abilities and reduce insulin resistance through a combination of resistance and aerobic exercises, according to a report in the January 26 issue of Archives of Internal Medicine.

27 Jan 2009

Statins may treat cerebral cavernous malformation

In a finding that could save thousands of lives a year, University of Utah School of Medicine researchers have shown that a blood vessel disorder leading to unpredictable, sometimes fatal, hemorrhagic strokes, seizures, paralysis or other problems is treatable with the same statin drugs that millions of people take to control high cholesterol.

27 Jan 2009

Opposite approach to asthma treatment may be in order

Just when the Food and Drug Administration is reconsidering the use of stimulants to treat asthma, a new research study offers further evidence to support a University of Houston professor's theory that an opposite approach to asthma treatment may be in order.

27 Jan 2009

Gene therapy for rheumatoid arthritis: promising results

Researchers have reported the first clinical evidence that gene therapy reduces symptoms in patients with rheumatoid arthritis, an important milestone for this promising treatment which has endured a sometimes turbulent past.

27 Jan 2009

Stromedix awarded U.S. patent for antibody-based therapeutics

Stromedix, Inc., a biotechnology company focused on innovative therapies for fibrosis and fibrotic organ failure, announced today that the U.S. Patent Office has granted patent number US 7,465,449, which broadly covers monoclonal antibodies to integrin ávâ6, including compositions related to its lead product, STX-100.

23 Jan 2009

Lisofylline drug improves type 2 insulin action; reduces harm of fat in preclinical study

Results of a preclinical study involving DiaKine Therapeutics' lead drug candidate Lisofylline (LSF) indicate the compound may reduce two key risk factors for type 2 diabetes.

23 Jan 2009

Can cognitive behavioural therapy help defeat depression?

The effectiveness of cognitive behavioural therapy (CBT) for the treatment of depression will be examined by researchers at the University of Bristol as part of the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme.

22 Jan 2009

Virotherapy treatment kills prostate cancer cells

A new study appearing in The Prostate has found that certain measles virus vaccine strain derivatives, including a strain known as MV-CEA, may prove to be an effective treatment for patients with advanced prostate cancer.

21 Jan 2009

Impaired kidney function raises risk of heart problems in the elderly

A study published next week in the open access journal PLoS Medicine suggests that elderly people with damaged kidneys are at greater risk of cardiovascular disease, such as heart failure and stroke, and other causes of mortality.

21 Jan 2009

Measurement of kidney function in children with kidney disease improved

A formula used to measure kidney function in children with chronic kidney disease has been revised to make it more precise, according to a study published today in the Journal of the American Society of Nephrology.

21 Jan 2009

Cream containing tretinoin associated with death in clinical trial, but relationship does not appear causal

Patients using a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, appeared more likely to die than those using a placebo in a clinical trial that was halted early as a result, according to a report in the January issue of Archives of Dermatology.

19 Jan 2009

Depressed adolescents not harmed by being part of placebo group in clinical trial

In a national clinical trial, adolescents with moderate to severe depression first given a placebo treatment and then an antidepressant medication alone or in combination with therapy responded just as well over the long term as participants who received active treatment throughout the study, UT Southwestern Medical Center researchers report.

19 Jan 2009

FDA issues complete response letter for SAPHRIS (asenapine) sublingual tablets in acute treatment of schizophrenia and bipolar disorder

Schering-Plough Corporation has announced that the U.S. Food and Drug Administration (FDA) has issued a complete response letter for SAPHRIS (asenapine) sublingual tablets in the acute treatment of schizophrenia in adults and in the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults as monotherapy.

15 Jan 2009

Probiotics prevent IgE-associated allergy until age 5 in cesarean-delivered children but not in total cohort

According to a recent study from the University and the University Central Hospital of Helsinki, Finland, no allergy-preventive effect is extended to age 5 years by perinatal supplementation with probiotics in babies at risk for developing allergies; protection is conferred only to Cesarean section babies.

15 Jan 2009

Advaxis wins European patent case involving Lovaxin-C vaccine

The European Patent Court in Munich, Germany has ruled in favor of Advaxis Incorporated and reversed a patent challenge made by Anza Therapeutics, Inc., formerly Cerus Corp.

15 Jan 2009

Treadmill exercise improves walking endurance for patients with PAD

Patients with peripheral arterial disease (PAD), which can include symptoms such as pain in the legs, who participated in supervised treadmill exercise improved their walking endurance and quality of life, according to a study in the January 14 issue of JAMA.

14 Jan 2009

Numerical analysis estimates numbers of older US adults who may benefit from statin therapy

Researchers estimate more than 11 million older Americans may be newly eligible for statin therapy if findings from a recently published large clinical trial are adopted into clinical practice guidelines, according to a new analysis of the trial data.

13 Jan 2009

Question marks over herbal remedies for menopausal symptoms

There is no strong evidence either way for several herbal remedies commonly taken to relieve troublesome menopausal symptoms, concludes the January issue of the Drug and Therapeutics Bulletin ( DTB ).

13 Jan 2009

Gene therapy kills brain tumors through selective recruitment of immune cells

Scientists seeking to harness the power of the immune system to eradicate brain tumors face two major hurdles: recruiting key immune cells called dendritic cells into areas of the brain where they are not naturally found and helping them recognize tumor cells as targets for attack.

13 Jan 2009

Clinical Trial News and Research

Medarex announces allowance of IND application for antibody-drug conjugate, MDX-1203

Study compares exercise regimens for obese older adults

Statins may treat cerebral cavernous malformation

Opposite approach to asthma treatment may be in order

Gene therapy for rheumatoid arthritis: promising results

Stromedix awarded U.S. patent for antibody-based therapeutics

Lisofylline drug improves type 2 insulin action; reduces harm of fat in preclinical study

Can cognitive behavioural therapy help defeat depression?

Virotherapy treatment kills prostate cancer cells

Impaired kidney function raises risk of heart problems in the elderly

Measurement of kidney function in children with kidney disease improved

Cream containing tretinoin associated with death in clinical trial, but relationship does not appear causal

Depressed adolescents not harmed by being part of placebo group in clinical trial

FDA issues complete response letter for SAPHRIS (asenapine) sublingual tablets in acute treatment of schizophrenia and bipolar disorder

Probiotics prevent IgE-associated allergy until age 5 in cesarean-delivered children but not in total cohort

Advaxis wins European patent case involving Lovaxin-C vaccine

Treadmill exercise improves walking endurance for patients with PAD

Numerical analysis estimates numbers of older US adults who may benefit from statin therapy

Question marks over herbal remedies for menopausal symptoms

Gene therapy kills brain tumors through selective recruitment of immune cells

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