Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Strategies to prevent and treat acute chest syndrome in children with sickle cell disease

Acute chest syndrome (ACS), a potentially severe lung complication of sickle cell disease, increases a child's risk of respiratory failure, chronic lung disease, and prolonged hospitalization if not recognized early and treated effectively.

5 Jan 2018

Research clarifies role of zinc transport mechanism in onset of obstructive pulmonary diseases

Obstructive pulmonary disease is a collective term for refractory respiratory diseases with chronic airway inflammation and excessive mucus retention that are accompanied by airway obstruction.

28 Dec 2017

Sickle cell patients, families and doctors face a ‘fight for everything’

The day before his 30th birthday, Marqus Valentine was in a panic. "I was so scared for midnight to come rolling around because subconsciously I was like, 'This is it. Tomorrow’s my last day on Earth,'" he said.

27 Dec 2017

Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease.

26 Dec 2017

New recommendations aim to improve diagnosis of liver disease, prevent unnecessary tests

New recommendations, led by experts at the University of Birmingham, have been published to improve the use of liver blood tests.

20 Dec 2017

Extracellular vesicles can be used to effectively delay progression of kidney damage

Researchers have demonstrated for the first time that extracellular vesicles - tiny protein-filled structures - isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage in mice with a type of chronic kidney disease.

15 Dec 2017

Relieving Symptoms of Cystic Fibrosis with Exercise

We know that exercise is beneficial in helping someone to maintain their lung function, stay strong and active and maintain a good quality of life. We also know that exercise can complement ‘airway clearance techniques’ – breathing exercises prescribed by physiotherapists to help clear the lungs of mucus.

14 Dec 2017

Protein structure could pave way for effective drugs to treat cystic fibrosis

Biochemists at the University of Zurich have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to treat cystic fibrosis.

13 Dec 2017

Researchers identify promising solution for improving cystic fibrosis treatments

Researchers at the University of Montreal Hospital Research Centre have identified a promising solution to improving treatments offered to patients with cystic fibrosis.

12 Dec 2017

SLU scientists provide promising approach in designing new drugs for DMD

In a paper published in the Nature journal Scientific Reports, Saint Louis University researchers report that a new drug reduces fibrosis (scarring) and prevents loss of muscle function in an animal model of Duchenne muscular dystrophy (DMD), providing a promising approach in designing new medications for those suffering from DMD.

8 Dec 2017

MIT researchers discover new way to make bacteria vulnerable to existing antibiotics

MIT researchers have discovered a way to make bacteria more vulnerable to a class of antibiotics known as quinolones, which include ciprofloxacin and are often used to treat infections such as Escherichia coli and Staphylococcus aureus.

8 Dec 2017

Study shows safety, efficacy of cystic fibrosis drug in children between 1 to 2 years of age

Ann & Robert H. Lurie Children's Hospital of Chicago is one of the study sites in the open label Phase 3 study that showed safety and effectiveness of the cystic fibrosis drug Kalydeco (ivacaftor) in children ages 1 to 2 years.

8 Dec 2017

Researchers discover how unusually long strands of RNA work in skin cells

Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells.

7 Dec 2017

Researchers establish function of long RNA strands in skin development and disease

Researchers have found out how long pieces of RNA called “long non-coding RNAs” (LncRNAs) work in skin cells to modulate connective tissue proteins such as collagen, potentially laying the foundations for new skin repair therapies.

7 Dec 2017

Unique liver function of South American amphibian could pave way for finding a cure to cirrhosis

The unique liver function of a South American amphibian, Siphonops annulatus, could pave the way to finding a cure to the devastating liver condition cirrhosis, a new study published in the prestigious Journal of Anatomy reports.

6 Dec 2017

Reducing mitochondrial protein in cardiac muscle cells initiates heart failure

Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure, a finding that could provide insight for new treatments for cardiovascular diseases, a study led by Georgia State University has shown.

6 Dec 2017

New targeted treatment could benefit patients with certain pancreatic tumors

Researchers at the University of Cincinnati College of Medicine have shown that a new targeted treatment could benefit patients with certain pancreatic tumors by preventing spread of the cancer and protecting their heart from damage--a direct result of the tumor.

1 Dec 2017

NIH grant supports research on cellular mechanisms governing longevity

The MDI Biological Laboratory has announced that Aric Rogers, Ph.D., has received a grant of $455,000 over two years from the National Institute on Aging, one of the institutes of the National Institutes of Health, for research on the cellular mechanisms governing longevity.

30 Nov 2017

Garlic compound can combat robust bacteria in patients with chronic infections

An active sulphurous compound found in garlic can be used to fight robust bacteria in patients with chronic infections, a new study from the University of Copenhagen indicates.

28 Nov 2017

Treatment with endogenous protein can heal scarring in the lungs

The endogenous protein RAGE, which has usually been negatively associated with chronic inflammation and diabetic complications, plays a major role in the repair of DNA damage - and also appears to heal tissue damaged as a result of accelerated cell senescence.

27 Nov 2017

Fibrosis News and Research

Further Reading

Strategies to prevent and treat acute chest syndrome in children with sickle cell disease

Research clarifies role of zinc transport mechanism in onset of obstructive pulmonary diseases

Sickle cell patients, families and doctors face a ‘fight for everything’

Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

New recommendations aim to improve diagnosis of liver disease, prevent unnecessary tests

Extracellular vesicles can be used to effectively delay progression of kidney damage

Relieving Symptoms of Cystic Fibrosis with Exercise

Protein structure could pave way for effective drugs to treat cystic fibrosis

Researchers identify promising solution for improving cystic fibrosis treatments

SLU scientists provide promising approach in designing new drugs for DMD

MIT researchers discover new way to make bacteria vulnerable to existing antibiotics

Study shows safety, efficacy of cystic fibrosis drug in children between 1 to 2 years of age

Researchers discover how unusually long strands of RNA work in skin cells

Researchers establish function of long RNA strands in skin development and disease

Unique liver function of South American amphibian could pave way for finding a cure to cirrhosis

Reducing mitochondrial protein in cardiac muscle cells initiates heart failure

New targeted treatment could benefit patients with certain pancreatic tumors

NIH grant supports research on cellular mechanisms governing longevity

Garlic compound can combat robust bacteria in patients with chronic infections

Treatment with endogenous protein can heal scarring in the lungs

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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