Amyotrophic Lateral Sclerosis News and Research

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Reduced function of key gene may affect communication between motor neurons and muscles in ALS

Amyotrophic lateral sclerosis, or ALS, attacks nerve cells known as motor neurons in the brain and spinal cord, gradually leading to paralysis.

30 Jun 2021

Differences in human and mouse brain cells have implications for research into neurological disorders

A UCLA-led study comparing brain cells known as astrocytes in humans and mice found that mouse astrocytes are more resilient to oxidative stress, a damaging imbalance that is a mechanism behind many neurological disorders.

25 Jun 2021

Scientists use new technology to optimize drug development for brain diseases

Dr. Hayder Amin and Dr. Caghan Kizil from the DZNE's Dresden site aim to speed up developing drugs against brain diseases through cutting-edge technology.

24 Jun 2021

Biomarker of chronic cellular stress is associated with Huntington's disease, shows study

A new University of California, Irvine-led study finds that the persistence of a marker of chronic cellular stress, previously associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), also takes place in the brains of Huntington's disease (HD) patients.

24 Jun 2021

Cedars-Sinai receives $11.99 million from CIRM to launch ALS clinical trial

Cedars-Sinai has been awarded $11.99 million by California's stem cell agency to launch a clinical trial testing a potential gene and stem cell therapy for amyotrophic lateral sclerosis (ALS).

23 Jun 2021

Research identifies distinctive inflammatory signature in a genetic form of ALS

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disease that strikes nearly 5,000 people in the U.S. every year. About 10% of ALS cases are inherited or familial, often caused by an error in the C9orf72 gene.

16 Jun 2021

QurAlis gears up for clinical development of therapeutic candidate, QRL-101

(BUSINESS WIRE)--QurAlis Corporation, a biotech company developing breakthrough precision medicines for ALS and other genetically validated neurodegenerative diseases, today announced the publication of an article in Cell Reports.

9 Jun 2021

Study provides new knowledge about molecular mechanisms underlying human traits, diseases

A new study analyzing the association between an individual's genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

1 Jun 2021

Study reveals potential mechanism for how traumatic brain injury leads to neurodegenerative diseases

Scientists have revealed a potential mechanism for how traumatic brain injury leads to neurodegenerative diseases, according to a study in fruit flies, and rat and human brain tissue, published today in eLife.

1 Jun 2021

Researchers discover a new and unique form of ALS

In a study of 11 medical-mystery patients, an international team of researchers led by scientists at the National Institutes of Health and the Uniformed Services University discovered a new and unique form of amyotrophic lateral sclerosis (ALS).

31 May 2021

Scientists identify many new gene variants that increase risk for depression

In the largest genetic analysis of depression to date, Veterans Affairs researchers identified many new gene variants that increase the risk for depression. The groundbreaking study helps researchers better understand the biological basis of depression and could lead to better drug treatments.

28 May 2021

Oleoyl-LPE promotes neurite outgrowth and protects against neuronal cell death

Lysophospholipids are phospholipids that have just one fatty acid chain, and in recent years, the role of lysophospholipids in physiology and pathophysiology has attracted attention.

12 May 2021

CNIO researchers unravel why motor neurons die in ALS patients

In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement leads to paralysis of muscles in the limbs and gradually of the whole body, which ultimately makes it impossible to breathe. ALS is currently untreatable, and its cause is unknown.

12 May 2021

Researchers use gene therapy to prevent learning, memory loss in Alzheimer's mouse model

Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used gene therapy to prevent learning and memory loss in a mouse model of Alzheimer's disease (AD), a key step toward eventually testing the approach in humans with the neurodegenerative disease.

5 May 2021

Amyotrophic Lateral Sclerosis News and Research

Reduced function of key gene may affect communication between motor neurons and muscles in ALS

Differences in human and mouse brain cells have implications for research into neurological disorders

Scientists use new technology to optimize drug development for brain diseases

Biomarker of chronic cellular stress is associated with Huntington's disease, shows study

Cedars-Sinai receives $11.99 million from CIRM to launch ALS clinical trial

Research identifies distinctive inflammatory signature in a genetic form of ALS

QurAlis gears up for clinical development of therapeutic candidate, QRL-101

Study provides new knowledge about molecular mechanisms underlying human traits, diseases

Study reveals potential mechanism for how traumatic brain injury leads to neurodegenerative diseases

Researchers discover a new and unique form of ALS

Scientists identify many new gene variants that increase risk for depression

Oleoyl-LPE promotes neurite outgrowth and protects against neuronal cell death

CNIO researchers unravel why motor neurons die in ALS patients

Researchers use gene therapy to prevent learning, memory loss in Alzheimer's mouse model

New miniaturized model of neuromuscular junction formation provides insight into ALS

Study provides new insights into how signal molecules are transported in the axons

Targeting brain protein may lead to new therapeutic approaches for neurodegenerative disorders

Population-based study shows the persistence of neutralizing antibodies against coronavirus

Researchers identify nonelectrical cells that transition the brain from plasticity to stability

Researchers test novel gene regulation approach to treat brain diseases

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