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Epigenetic changes in the brain drive late-onset Alzheimer's disease

New findings suggest that late-onset Alzheimer's Disease is driven by epigenetic changes -- how and when certain genes are turned on and off -- in the brain. Results were published today in Nature Genetics.

28 Sep 2020

Research uncovers potential cause of neurotoxicity due to immunotherapy

New research has uncovered the previously unknown presence of CD19 -- a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma -- in brain cells that protect the blood brain barrier (BBB).

21 Sep 2020

Older racial and ethnic minority nursing home residents suffer the most from COVID-19

Older racial and ethnic minority residents and their caregivers bear the severest brunt from COVID-19 across the entire spectrum of US nursing homes and assisted living communities, University of Rochester Medical Center researchers report in two groundbreaking studies in the Journal of the American Geriatrics Society

21 Sep 2020

First clinical trial launched to test psilocybin therapy for depression in cancer patients

The first clinical trial to test the safety and feasibility of psilocybin therapy with simultaneous administration and one-on-one patient support to treat depression in cancer patients was launched today by Maryland Oncology Hematology at the Aquilino Cancer Center at Adventist HealthCare Shady Grove Medical Center.

16 Sep 2020

New dental treatment helps fill cavities and insurance gaps for seniors

Dental hygienist Jennifer Geiselhofer often cleans the teeth of senior patients who can't easily get to a dentist's office. But until recently, if she found a cavity, there was little she could do.

15 Sep 2020

IU School of Medicine and partners receive funding to deploy collaborative dementia care model

Supported by a $1.3 million grant from the U.S. Administration for Community Living, Department of Health and Human Services, Indiana University School of Medicine and its partners have launched a 36-month venture to enhance, strengthen and expand supports for people with Alzheimer's Disease and Related Dementias (ADRD) and their caregivers in 34 Indiana counties.

14 Sep 2020

Scientists solve decades old mystery of key molecule that fuels mitochondria

Penn Medicine researchers have solved a decades old mystery around a key molecule fueling the power plant of cells that could be exploited to find new ways to treat diseases, from neurodegenerative disorders to cancer.

10 Sep 2020

Hestia criteria, sPESI score can be used to select pulmonary embolism patients for outpatient care

Patients with acute pulmonary embolism can be selected for home management using the sPESI score or the Hestia criteria, according to results of the HOME-PE trial presented in a Hot Line session today at ESC Congress 2020.

31 Aug 2020

Older adults living in rural settings are less likely to receive health and nutrition services

Older adults living in very rural settings are less likely than those living closer to urban centers to receive available services in health, nutrition and transportation, according to a new study by a Washington State University scientist.

24 Aug 2020

Mount Sinai's Arnhold Institute for Global Health and NYC Health + Hospitals launch CURE-19

The Arnhold Institute for Global Health at the Icahn School of Medicine at Mount Sinai and NYC Health + Hospitals have launched the COVID-19 Unit for Research at Elmhurst (CURE-19).

12 Aug 2020

NCI gives 'exceptional' rating to Penn's Abramson Cancer Center

The National Cancer Institute has once again rated the Abramson Cancer Center of the University of Pennsylvania as "exceptional," the highest possible rating for an NCI-designated comprehensive cancer center.

4 Aug 2020

Computed tomography can serve as effective tool for diagnosing COVID-19

The use of computed tomography in outpatient computed tomography centers (OCTC) is entirely consistent with the clinical data and global best practices. This is also an effective tool for diagnosing the coronavirus infection COVID-19

29 Jul 2020

Study identifies common characteristics of pediatric vestibular schwannomas

Vestibular schwannomas, more commonly known as acoustic neuromas, are benign brain tumors that develop on the balance (vestibular) and hearing or auditory nerves leading from the inner ear to the brain.

23 Jul 2020

Home care for older persons has deteriorated significantly during COVID-19 crisis

The care situation of older persons who receive care at home has deteriorated significantly during of the COVID-19 crisis.

21 Jul 2020

Emerging hydrogel material could improve oral drug delivery

An emerging hydrogel material with the capacity to degrade and spontaneously reform in the gastrointestinal tract could help researchers develop more effective methods for oral drug delivery.

16 Jul 2020

Rare inherited mutation in TP53 gene confers risk of multiple cancers

Rare inherited mutations in the body's master regulator of the DNA repair system – the TP53 gene – can leave people at a higher risk of developing multiple types of cancer over the course of their lives.

16 Jul 2020

New immune profiles could help predict disease trajectory in severe COVID-19 patients

Researchers from the Penn Institute of Immunology discovered three distinct immune responses to the SARS-CoV2 infection that could help predict the trajectory of disease in severe COVID-19 patients and may ultimately inform how to best treat them.

15 Jul 2020

Delirium linked to long-term cognitive decline

A new meta-analysis of 24 observational studies from researchers at Columbia University Vagelos College of Physicians and Surgeons found that delirium may cause significant long-term cognitive decline.

13 Jul 2020

Manifestations of COVID-19 in newborn babies

In a new study titled, “The clinical course of SARS-CoV-2 positive neonates,” Italian researchers led by Guiseppe De Bernado from Division of Pediatrics Neonatology and NICU, Ospedale Buon Consiglio Fatebenefratelli, Naples, explain the course of the infection among newborn babies.

9 Jul 2020

Study examines the long-term impacts of child abuse

In a new study published in the leading international journal, Child Abuse and Neglect, University of South Australia researchers have found that by their mid-teens, children who were the subject of child protective services contact, are up to 52 percent more likely to be hospitalized, for a range of problems, the most frequent being mental illness, toxic effects of drugs and physical injuries.