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Senescent brain immune cells secrete protein linked to cognitive decline

Brain-resident immune cells that have reached an old-age state called "senescence" secrete a protein that causes dysfunction in other brain cells, according to a study led by investigators at Weill Cornell Medicine.

11 Aug 2026

Shared cellular pathway drives neurodegeneration in rare childhood dementia and Alzheimer’s

Researchers at University of California San Diego and their colleagues have identified a key cellular pathway that drives brain degeneration in both a rare childhood disorder and the far more common Alzheimer's disease.

11 Aug 2026

Dexamethasone calms lung inflammation without weakening core immune responses

Researchers from Trinity College Dublin and St. James's Hospital have shown that dexamethasone, a commonly prescribed anti-inflammatory steroid, can reduce harmful inflammation triggered by Mycobacterium avium without weakening the ability of human immune cells to control the infection.

11 Aug 2026

New computational tool identifies hidden genes driving asthma

Researchers at Columbia University Mailman School of Public Health, in collaboration with investigators at the University of Chicago, have developed a new computational framework that helps scientists identify genes that play central roles in diseases such as asthma but are often overlooked by existing genetic analysis methods.

11 Aug 2026

New multi-protein blood test accurately detects late-stage Alzheimer's disease

Researchers have identified seven proteins in the blood that could enable better blood tests for Alzheimer's disease.

11 Aug 2026

Semaglutide slows blood protein signature linked to future dementia risk

A post hoc analysis of 2,970 older SELECT participants found that semaglutide slowed worsening of a 25-protein blood signature that predicts future dementia risk. Over 104 weeks, semaglutide produced larger effects on modeled 5-year than 20-year dementia risk, but whether these biomarker changes translate into less cognitive decline or dementia remains unknown.

10 Aug 2026

Study identifies key immune cell changes in the lungs of people with sarcoidosis

Researchers at National Jewish Health and partner institutions discovered specific changes in immune cells in the lungs of people with sarcoidosis.

10 Aug 2026

Natural hormone activates brain-to-liver signaling pathway to suppress liver inflammation

Researchers at McMaster University have discovered that a naturally occurring hormone best known for suppressing appetite and promoting weight loss also helps protect the liver from inflammation through a previously unknown signalling pathway, opening new possibilities for treating advanced fatty liver disease.

10 Aug 2026

Scientific statement reframes cardiovascular care for older patients with cognitive impairment and frailty

Older adults with cardiovascular disease (CVD) often have coexisting cognitive impairment and frailty, conditions that can significantly affect treatment decisions, recovery, independence and quality of life and should be considered as part of an aging-informed approach to care, according to a new American College of Cardiology Scientific Statement published in JACC, the flagship journal of the ACC.

10 Aug 2026

New pathway explains how zombie cells trigger chronic inflammation

Researchers have uncovered a previously unknown mechanism that helps aging cells drive the chronic inflammation linked to many age-related diseases.

10 Aug 2026

Newly discovered protein pathway limits spinal cord injury damage

Spinal cord injury begins with immediate mechanical damage, but much of the lasting neurological loss develops during the secondary phase, when inflammation, oxidative stress and disrupted metabolism continue to injure surviving tissue.

10 Aug 2026

Simple biological age score flags higher cognitive decline risk in older adults

A study of 4,818 middle-aged and older Chinese adults found that higher light BioAge was associated with greater risks of cognitive impairment, episodic memory decline, and reduced mental intactness. The simple measure, based on age, creatinine, glucose, and CRP, added modest predictive information but requires further validation before clinical use.

10 Aug 2026

Why pulses could play a bigger role in healthy and sustainable diets

A narrative review finds that pulses may support gut and metabolic health through their fiber, protein, phytochemicals, and interactions with the gut microbiota, while offering a lower environmental footprint than many animal protein sources. Human evidence is strongest for selected cardiometabolic outcomes, while many microbiome and fermentation-related benefits remain supported mainly by animal and laboratory studies.

9 Aug 2026

New drug delivers promising survival gains in pancreatic cancer

About 90% of people with pancreatic cancer have pancreatic ductal adenocarcinoma (PDAC), which is driven by an activating mutation in the KRAS gene.

9 Aug 2026

Study uncovers molecular trigger behind pyrin inflammation in familial Mediterranean fever

Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease in which the body's own immune system overreacts to minimal or inappropriate stimuli, producing recurrent attacks of fever and painful inflammation.

7 Aug 2026

Piezo ion channels: Key regulators of digestive health and disease

Mechanosensitive Piezo ion channels, particularly Piezo1 and Piezo2, are gaining recognition as central regulators of digestive system physiology and disease.

7 Aug 2026

New review explores purinergic signaling pathways in osteoarthritis progression

A growing understanding of purinergic signaling is reshaping how scientists view osteoarthritis (OA), revealing an intricate communication network that influences joint inflammation, cartilage degeneration, bone remodeling, and chronic pain.

7 Aug 2026

Disrupted RNA methylation pathway accelerates Alzheimer’s and Parkinson’s risks

A growing understanding of RNA biology is reshaping how scientists view the relationship between environmental toxicants, brain development, and neurodegenerative disease.

7 Aug 2026

Scientists map key differences in stem cell potency for treating knee osteoarthritis

Knee osteoarthritis (KOA) affects more than 1 in 10 people over 40 years of age, impairing patients' mobility and quality of life.

7 Aug 2026

Fine particle pollution raises rheumatoid arthritis flare risk and disease activity

Higher ambient PM2.5 exposure was associated with increased rheumatoid arthritis disease activity and a greater likelihood of flares in a four-year South Korean cohort of 1,070 patients. The association appeared stronger with sustained exposure over approximately two weeks or longer, while women and nonsmokers showed more pronounced links between PM2.5 and DAS28-CRP.

7 Aug 2026