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The molecular mechanism that turns cool temps into nerve signals

When you reach into a bucket of ice, open your front door on a snowy day, or feel the tingle of menthol toothpaste, a protein in your nerve cells called TRPM8 springs into action, opening like a tiny gate to send a "cold" signal to your brain.

26 Mar 2026

Scientists identify new target to slow Huntington’s disease progression

Huntington's disease is a devastating brain disorder that slowly robs people of movement, memory and personality.

23 Mar 2026

Scientists reveal how light-activated drugs change receptor activity

Rendering a drug effective or ineffective in a flash at the appropriate location – this is the focus of research in photopharmacology.

19 Mar 2026

Blocking a single protein could make hidden HPV-positive tumors vulnerable to treatment

A team of scientists at Henry Ford Health + Michigan State University Health Sciences have uncovered a mechanism that allows certain head and neck cancers to hide from the immune system, a discovery that could change how some of the most treatment resistant tumors are approached.

18 Mar 2026

Muscle-repairing macrophages trigger heterotopic ossification in mice

We have identified a macrophage population "Mrep" that plays an essential role in muscle repair. However, in Fibrodysplasia ossificans progressiva (FOP), Mrep functions as a pathogenic cell that triggers heterotopic ossification.

18 Mar 2026

Newly identified protein regulates lysosome positioning and cellular metabolism

Lysosomes are the control centers for the metabolism of cells and tissues, including the brain. They break down defective proteins and other macromolecules into their basic building blocks.

18 Mar 2026

Study identifies brain pathway crucial for proper functioning of working memory

Working memory is a cognitive function that is essential for carrying out everyday activities and temporarily retaining information.

17 Mar 2026

Study reveals new dual role of ezrin in osteosarcoma

Scientists at Georgetown University's Lombardi Comprehensive Cancer Center have uncovered a new dual function for a well-known cancer-related protein called ezrin.

17 Mar 2026

Study uncovers how tuberculosis bacteria fuel themselves during infection

Researchers at The Hospital for Sick Children (SickKids) have uncovered how the bacteria that causes tuberculosis fuels itself during infection, providing new insights into one of the world's deadliest infectious diseases.

17 Mar 2026

FDA-approved drug fedratinib enhances communication between cellular organelles

Cells behave like cities and organelles carry out infrastructural roles: Mitochondria are powerhouses, the endoplasmic reticulum serves as a transport hub and lysosomes help with waste disposal.

13 Mar 2026

Circular RNA produced by HIV boosts viral replication

For decades scientists have recognized that human immunodeficiency virus (HIV) is a formidable viral pathogen.

13 Mar 2026

SonoPIN technology boosts intracellular delivery of large cancer drugs

Engineers at Duke University have demonstrated a technique that uses microbubbles and ultrasound to help relatively large cancer drugs enter tumor cells and cause them to self-destruct.

13 Mar 2026

Pen-strep treatment rewires mechanical sensing in immune cells

Macrophages are central to mechanobiology research: their physical characteristics-stiffness, adhesion, and ECM (extracellular matrix) sensing-are inextricably linked to their phenotypic polarization and immune function.

13 Mar 2026

Scientists uncover unexpected cancer target on tumor cell surfaces

For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden from the immune system.

12 Mar 2026

Innovative microscopic capsules overcome long-standing limitations in single-cell research

Researchers have developed a capsule-based method that makes it possible to analyse the same cell through multiple experimental steps.

12 Mar 2026

Adding three simple amino acids boosts mRNA and CRISPR delivery

Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution.

12 Mar 2026

The 0.05 EU/mg breakthrough: How Sino Biological ProPure™ is redefining the Ultra-Low Endotoxin standard

When we discuss bacterial infections, we often think of exotoxins—those soluble proteins actively secreted by bacteria—while overlooking endotoxins, which are more insidious but equally dangerous.

From Sino Biological Inc. 12 Mar 2026

Boron-assisted reactions overcome solubility barriers in protein synthesis

Chemists from ETH Zurich have found a way to produce poorly soluble proteins by caging a uniquely reactive boron compound.

10 Mar 2026

New catalog identifies dozens of plasma membrane repair proteins

In the evolutionary history of life, the ability of a cell to separate its inner world from the external environment was an important turning point.

10 Mar 2026

Single receptor PAR1 controls opposing responses in blood vessels

Researchers at the University of California San Diego have uncovered how a single protein triggers two opposite responses in blood vessels - one inflammatory and one protective.

10 Mar 2026