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New protein target offers promise for alleviating cognitive decline in Parkinson's disease

A recently published study by researchers at the University of Arizona Health Sciences found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders.

19 Nov 2024

Study highlights air pollution as key environmental factor in autism risk

Air pollution is a key environmental risk factor for autism, influencing neurodevelopment through neuroinflammation, oxidative stress, and epigenetic changes.

14 Nov 2024

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Professor Nancy Ip discusses her groundbreaking neuroscience research, focusing on neurotrophic factors and innovative Alzheimer's disease treatment approaches.

13 Nov 2024

Research highlights immune system's role in depression

A new study highlights the link between inflammation and depression, challenging traditional neurotransmitter-focused theories.

11 Nov 2024

Understanding the role of neuroimmune cells in brain health and disease

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system.

6 Nov 2024

New model sheds light on APOE4's role in Alzheimer's pathology

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein - the most important genetic risk factor for Alzheimer's disease - the same cells cause harmful inflammation and clumps of misfolded proteins, according to a new study by scientists at Gladstone Institutes.

4 Nov 2024

The crucial role of sleep in heart healing

Researchers examine how sleep impacts inflammation and recovery following a heart attack.

31 Oct 2024

Mechanisms of neurogenesis after stroke revealed

Researchers at the University of Freiburg have studied what happens immediately after a stroke in the stem cell niche known as the subventricular zone, using a mouse model.

24 Oct 2024

The molecular underpinnings by which traumatic brain injury increases Alzheimer's disease risk

Findings indicate BAG3 modulation after traumatic brain injury may mitigate tau buildup and cognitive deficits, presenting a target for Alzheimer's prevention.

18 Oct 2024

Researchers uncover distinct cell vulnerabilities in Alzheimer’s progression with novel multiomics approach

Researchers used single-cell and spatial genomics to map cell-type-specific changes in the middle temporal gyrus, identifying distinct disease phases in Alzheimer’s progression.

16 Oct 2024

Semaglutide enhances cognitive abilities and reduces Alzheimer’s pathology in mice and human brain models

Researchers find that Semaglutide improves cognitive function and reduces amyloid and tau pathology in Alzheimer's disease models, while restoring oxytocin levels in both mice and human brain organoids.

14 Oct 2024

Differential gene expression linked to alcohol use disorder, offering new treatment possibilities

Researchers identified key gene expression differences in addiction-relevant brain regions that provide new insights into alcohol use disorder and potential therapeutic targets.

14 Oct 2024

Transposable elements found to be dysregulated in Alzheimer's brains, revealing potential targets for therapy

Study reveals widespread dysregulation of transposable elements (TEs) in aging human brains with Alzheimer's disease, using advanced techniques like CRISPR interference to identify TE-related risk genes.

9 Oct 2024

Liver X receptor beta offers new hope in treating depression and anxiety

Liver X receptor beta (LXRβ) shows potential in reducing depression and anxiety by improving neurogenesis, reducing neuroinflammation, and enhancing cognitive and emotional function. More research on LXR agonists could reveal new treatments for mental health disorders.

8 Oct 2024

GLP-1 drugs protect brain health by improving neurovascular function and reducing inflammation

Research highlights how GLP-1 receptor agonists may improve brain health by targeting the neurovascular unit, linking metabolic health to cognitive function. It suggests potential therapies for neurodegenerative diseases like Alzheimer's.

7 Oct 2024

Lithium aspartate fails to improve long COVID symptoms, but higher doses may hold promise

Lithium aspartate at 10-15 mg/d is ineffective for treating cognitive dysfunction and fatigue in long COVID, but higher doses may offer potential benefits based on a small follow-up study.

3 Oct 2024

Two genetic variants linked to Alzheimer's trigger microglial inflammation in females

Weill Cornell Medicine investigators have found that two genetic variants that confer high risk of Alzheimer's disease (AD) together trigger a harmful inflammatory response in the brain's immune cells, particularly in females, in a preclinical model.

30 Sep 2024

How viral persistence and immune dysfunction drive long COVID

Study explores the biological drivers and mechanisms of long COVID, shedding light on its epidemiology and potential therapeutic interventions. It emphasizes the role of viral persistence, immune dysfunction, and coagulation in the development of this condition.

29 Sep 2024

Calcium channel blockers show potential to restore cerebral blood flow in Alzheimer's disease

Targeting calcium channels in pericytes may improve blood flow in Alzheimer's disease, addressing early vascular dysfunction linked to cognitive deficits.

23 Sep 2024

Study reveals biomarkers that predict disability worsening in multiple sclerosis

A pioneering study presented today at ECTRIMS 2024 has identified critical biomarkers that can predict disability worsening in multiple sclerosis (MS).

19 Sep 2024