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Serotonin may worsen tinnitus symptoms, mice study finds

The same neurotransmitter commonly leveraged to relieve symptoms of depression and anxiety also may exacerbate a vexing condition known as tinnitus, according to new research published in the Proceedings of the National Academy of Sciences.

20 Apr 2026

New gene target offers hope for fatal infant cardiomyopathy

Researchers from the Keck School of Medicine of USC have made an important advance toward understanding-and potentially treating-a rare cardiomyopathy (heart muscle disease) that is present from birth.

20 Apr 2026

Metastatic cells can be identified within primary breast tumors

Understanding which cells within a tumor will go on to form metastases remains one of the major challenges in cancer research.

20 Apr 2026

New atlas maps how the vascular network of mouse's brain grows after birth

Scientists have made a major advance in developmental neuroscience, creating the very first detailed atlas of how the vascular network of a mouse's brain grows after birth. Their study is published in Cell.

17 Apr 2026

Age shapes melanoma progression and immune response

Cancer risk increases with age and is often more aggressive and difficult to treat in older adults. However, fewer than 10% of mouse studies use aged animals, with most relying on mice roughly equivalent to humans in their early 20s.

17 Apr 2026

How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

This review argues that neurodegeneration is shaped not only by toxic protein buildup but also by immune signaling, with microglia and T cells able to either protect the brain or worsen damage depending on context. It also highlights aging, head injury, and viral infection as major forces that reshape CNS immunity and may influence disease progression and future treatment strategies.

16 Apr 2026

Study reveals why endometriosis pain persists after lesions are removed

Repeated menstrual cycles may do more than trigger endometriosis. They may rewire the brain.

16 Apr 2026

New model advances study of cardiac fibroblasts and fibrosis

Fibroblasts are an essential component of the heart, as they play key roles in its structure, development and response to cardiac damage.

15 Apr 2026

Study reveals interhemispheric brain circuit crucial for spatial memory

A team led by the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has identified a brain circuit essential for spatial memory.

14 Apr 2026

Common osteoporosis drugs could slow or halt aneurysm progression

Aortic aneurysms are characterized by abnormal enlargement of the aorta, the primary artery responsible for carrying blood from the heart. Rupture often leads to sudden death, and currently, no effective drug therapies are available to halt disease progression.

14 Apr 2026

Alzheimer's risk gene APOE4 impacts bone health in females

Scientists at the Buck Institute for Research on Aging, along with collaborators at UC San Francisco, have discovered that APOE4, the most common genetic risk factor for Alzheimer's disease, causes bone quality deficits specifically in female mice, through a mechanism that is invisible to standard imaging and can emerge as early as midlife.

13 Apr 2026

Study explains why vaccines underperform in people living with obesity

New findings reveal that obesity significantly impaired the quality and longevity of antibody responses to a Pseudomonas aeruginosa vaccine in a mouse model.

13 Apr 2026

Researchers identify molecular link between autoimmune disease and lymphoma risk

Patients with autoimmune diseases such as lupus and rheumatoid arthritis have an increased risk of developing lymphoma, a form of blood cancer that affects the lymphatic system.

13 Apr 2026

Targeted diet helps reprogram aggressive neuroblastoma in mice

Researchers highlighted how an arginine- and proline-restricted diet combined with eflornithine reprogrammed MYCN-driven neuroblastoma in mice, pushing tumor cells out of the cell cycle and toward differentiation. The commentary argues that this metabolism-to-translation link could open a new path for testing targeted dietary strategies alongside cancer drugs in future clinical studies.

9 Apr 2026

Insilico Medicine nominates AI-driven drug candidate for cancer, Cushing's syndrome and obesity

The NR3C1 (nuclear receptor subfamily 3 group C member 1) gene encodes the glucocorticoid receptor (GR), a nuclear receptor vital for maintaining physiological homeostasis, and inhibition of NR3C1 could increase the sensitivity of cancer cells to standard chemotherapy, particularly in ovarian cancer.

8 Apr 2026

Xuebijing injection reduces inflammation and ferroptosis in acute lung injury

Using an LPS-induced ALI mouse model and LPS-stimulated alveolar macrophages, they found XBJ reduced inflammatory cytokine surges, preserved alveolar barrier integrity, and limited tissue injury, while probing the molecular pathways and intracellular targets underlying these benefits.

7 Apr 2026